| An integrated encyclopedia of DNA elements in the human genome ENCODE Project Consortium Nature 489 (7414), 57, 2012 | 17594 | 2012 |
| Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project Management Group Liefer Laura A. 51 Wetterstrand Kris A. 51 Good Peter J. 51 ... nature 447 (7146), 799-816, 2007 | 6125 | 2007 |
| Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genome ND Heintzman, RK Stuart, G Hon, Y Fu, CW Ching, RD Hawkins, ... Nature genetics 39 (3), 311-318, 2007 | 4063 | 2007 |
| The accessible chromatin landscape of the human genome RE Thurman, E Rynes, R Humbert, J Vierstra, MT Maurano, E Haugen, ... Nature 489 (7414), 75-82, 2012 | 3207 | 2012 |
| Histone modifications at human enhancers reflect global cell-type-specific gene expression ND Heintzman, GC Hon, RD Hawkins, P Kheradpour, A Stark, LF Harp, ... Nature 459 (7243), 108-112, 2009 | 2990 | 2009 |
| Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression NR Wray, S Ripke, M Mattheisen, M Trzaskowski, EM Byrne, A Abdellaoui, ... Nature genetics 50 (5), 668-681, 2018 | 2948 | 2018 |
| The ENCODE (ENCyclopedia of DNA elements) project EA Feingold, PJ Good, MS Guyer, S Kamholz, L Liefer, K Wetterstrand, ... Science 306 (5696), 636-640, 2004 | 2460 | 2004 |
| Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers IB Hilton, AM D'ippolito, CM Vockley, PI Thakore, GE Crawford, TE Reddy, ... Nature biotechnology 33 (5), 510-517, 2015 | 2222 | 2015 |
| High-resolution mapping and characterization of open chromatin across the genome AP Boyle, S Davis, HP Shulha, P Meltzer, EH Margulies, Z Weng, ... Cell 132 (2), 311-322, 2008 | 1775 | 2008 |
| RNA-guided gene activation by CRISPR-Cas9–based transcription factors P Perez-Pinera, DD Kocak, CM Vockley, AF Adler, AM Kabadi, ... Nature methods 10 (10), 973-976, 2013 | 1733 | 2013 |
| A user's guide to the encyclopedia of DNA elements (ENCODE) ENCODE Project Consortium PLoS biology 9 (4), e1001046, 2011 | 1499 | 2011 |
| Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements PI Thakore, AM D'ippolito, L Song, A Safi, NK Shivakumar, AM Kabadi, ... Nature methods 12 (12), 1143-1149, 2015 | 1070 | 2015 |
| Comprehensive functional genomic resource and integrative model for the human brain D Wang, S Liu, J Warrell, H Won, X Shi, FCP Navarro, D Clarke, M Gu, ... Science 362 (6420), eaat8464, 2018 | 949 | 2018 |
| Defining functional DNA elements in the human genome M Kellis, B Wold, MP Snyder, BE Bernstein, A Kundaje, GK Marinov, ... Proceedings of the National Academy of Sciences 111 (17), 6131-6138, 2014 | 906 | 2014 |
| DNase-seq: a high-resolution technique for mapping active gene regulatory elements across the genome from mammalian cells L Song, GE Crawford Cold Spring Harbor Protocols 2010 (2), pdb. prot5384, 2010 | 867 | 2010 |
| DNase I sensitivity QTLs are a major determinant of human expression variation JF Degner, AA Pai, R Pique-Regi, JB Veyrieras, DJ Gaffney, JK Pickrell, ... Nature 482 (7385), 390-394, 2012 | 819 | 2012 |
| Dynamic DNA methylation across diverse human cell lines and tissues KE Varley, J Gertz, KM Bowling, SL Parker, TE Reddy, F Pauli-Behn, ... Genome research 23 (3), 555-567, 2013 | 812 | 2013 |
| Assessment of bidirectional relationships between physical activity and depression among adults: a 2-sample Mendelian randomization study KW Choi, CY Chen, MB Stein, YC Klimentidis, MJ Wang, KC Koenen, ... JAMA psychiatry 76 (4), 399-408, 2019 | 678 | 2019 |
| Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity L Song, Z Zhang, LL Grasfeder, AP Boyle, PG Giresi, BK Lee, ... Genome research 21 (10), 1757-1767, 2011 | 648 | 2011 |
| Genome-wide mapping of DNase hypersensitive sites using massively parallel signature sequencing (MPSS) GE Crawford, IE Holt, J Whittle, BD Webb, D Tai, S Davis, EH Margulies, ... Genome research 16 (1), 123-131, 2006 | 627 | 2006 |
