| Large-scale structural analysis of the classical human protein tyrosine phosphatome AJ Barr, E Ugochukwu, WH Lee, ONF King, P Filippakopoulos, I Alfano, ... Cell 136 (2), 352-363, 2009 | 562 | 2009 |
| Structural basis for protein–protein interactions in the 14-3-3 protein family X Yang, WH Lee, F Sobott, E Papagrigoriou, CV Robinson, ... Proceedings of the National Academy of Sciences 103 (46), 17237-17242, 2006 | 490 | 2006 |
| Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases TL Davis, JR Walker, V Campagna-Slater, PJ Finerty Jr, R Paramanathan, ... PLoS biology 8 (7), e1000439, 2010 | 338 | 2010 |
| Structure of the CaMKIIδ/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation P Rellos, ACW Pike, FH Niesen, E Salah, WH Lee, F Von Delft, S Knapp PLoS biology 8 (7), e1000426, 2010 | 292 | 2010 |
| Comparative structural analysis of lipid binding START domains AG Thorsell, WH Lee, C Persson, MI Siponen, M Nilsson, RD Busam, ... Plos one 6 (6), e19521, 2011 | 147 | 2011 |
| Fast structure-based virtual ligand screening combining FRED, DOCK, and Surflex MA Miteva, WH Lee, MO Montes, BO Villoutreix Journal of medicinal chemistry 48 (19), 6012-6022, 2005 | 146 | 2005 |
| Crystal Structures of the p21-activated kinases PAK4, PAK5, and PAK6 reveal catalytic domain plasticity of active group II PAKs J Eswaran, WH Lee, JÉ Debreczeni, P Filippakopoulos, A Turnbull, ... Structure 15 (2), 201-213, 2007 | 140 | 2007 |
| Reduced phosphatase activity of SHP‐2 in LEOPARD syndrome: Consequences for PI3K binding on Gab1 N Hanna, A Montagner, WH Lee, M Miteva, M Vidal, M Vidaud, B Parfait, ... FEBS letters 580 (10), 2477-2482, 2006 | 135 | 2006 |
| Structural and biochemical characterization of human orphan DHRS10 reveals a novel cytosolic enzyme with steroid dehydrogenase activity P Lukacik, B Keller, G Bunkoczi, K Kavanagh, W Hwa Lee, J Adamski, ... Biochemical Journal 402 (3), 419-427, 2007 | 112 | 2007 |
| Crystal structure of the PIM2 kinase in complex with an organoruthenium inhibitor AN Bullock, S Russo, A Amos, N Pagano, H Bregman, JE Debreczeni, ... PloS one 4 (10), e7112, 2009 | 111 | 2009 |
| Novel mutations in ACVR1 result in atypical features in two fibrodysplasia ossificans progressiva patients KA Petrie, WH Lee, AN Bullock, JJ Pointon, R Smith, RGG Russell, ... PloS one 4 (3), e5005, 2009 | 106 | 2009 |
| Structural Basis for Low Catalytic Activity in Lys49 Phospholipases A2A Hypothesis: The Crystal Structure of Piratoxin II Complexed to Fatty Acid, WH Lee, MT da Silva Giotto, S Marangoni, MH Toyama, I Polikarpov, ... Biochemistry 40 (1), 28-36, 2001 | 102 | 2001 |
| Characterization of human DHRS6, an orphan short chain dehydrogenase/reductase enzyme: a novel, cytosolic type 2 R-β-hydroxybutyrate dehydrogenase K Guo, P Lukacik, E Papagrigoriou, M Meier, WH Lee, J Adamski, ... Journal of Biological Chemistry 281 (15), 10291-10297, 2006 | 90 | 2006 |
| Structural basis of fumarate hydratase deficiency S Picaud, KL Kavanagh, WW Yue, WH Lee, S Muller-Knapp, O Gileadi, ... Journal of inherited metabolic disease 34, 671-676, 2011 | 83 | 2011 |
| The scientific impact of the Structural Genomics Consortium: a protein family and ligand-centered approach to medically-relevant human proteins O Gileadi, S Knapp, WH Lee, BD Marsden, S Müller, FH Niesen, ... Journal of structural and functional genomics 8, 107-119, 2007 | 80 | 2007 |
| Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases J Eswaran, JP von Kries, B Marsden, E Longman, JÉ Debreczeni, ... Biochemical Journal 395 (3), 483-491, 2006 | 77 | 2006 |
| Structural basis for substrate specificity in human monomeric carbonyl reductases ES Pilka, FH Niesen, WH Lee, Y El-Hawari, JE Dunford, G Kochan, ... PloS one 4 (10), e7113, 2009 | 69 | 2009 |
| Structural comparison of human mammalian ste20-like kinases CJ Record, A Chaikuad, P Rellos, S Das, ACW Pike, O Fedorov, ... PloS one 5 (8), e11905, 2010 | 66 | 2010 |
| Preclinical target validation using patient-derived cells AM Edwards, CH Arrowsmith, C Bountra, ME Bunnage, M Feldmann, ... Nature Reviews Drug Discovery 14 (3), 149-150, 2015 | 58 | 2015 |
| Disseminating structural genomics data to the public: from a data dump to an animated story R Abagyan, WH Lee, E Raush, L Budagyan, M Totrov, M Sundstrom, ... Trends in biochemical sciences 31 (2), 76-78, 2006 | 55 | 2006 |
Brian MarsdenCentre for Medicines Discovery & Centre for Human Genetics, NDM, University of OxfordE-mail megerősítve itt: cmd.ox.ac.uk