Targeted gene correction of α1-antitrypsin deficiency in induced pluripotent stem cells K Yusa, ST Rashid, H Strick-Marchand, I Varela, PQ Liu, DE Paschon, ... Nature 478 (7369), 391-394, 2011 | 824 | 2011 |
The ribosomal P-stalk couples amino acid starvation to GCN2 activation in mammalian cells HP Harding, A Ordonez, F Allen, L Parts, AJ Inglis, RL Williams, D Ron Elife 8, e50149, 2019 | 163 | 2019 |
Antithrombin Cambridge II (A384S): an underestimated genetic risk factor for venous thrombosis J Corral, D Hernandez-Espinosa, JM Soria, R Gonzalez-Conejero, ... Blood 109 (10), 4258-4263, 2007 | 153 | 2007 |
Endoplasmic reticulum polymers impair luminal protein mobility and sensitize to cellular stress in alpha1‐antitrypsin deficiency A Ordóñez, EL Snapp, L Tan, E Miranda, SJ Marciniak, DA Lomas Hepatology 57 (5), 2049-2060, 2013 | 135 | 2013 |
Emergence of a stage-dependent human liver disease signature with directed differentiation of alpha-1 antitrypsin-deficient iPS cells AA Wilson, L Ying, M Liesa, CP Segeritz, JA Mills, SS Shen, J Jean, ... Stem cell reports 4 (5), 873-885, 2015 | 100 | 2015 |
Circulating polymers in α1-antitrypsin deficiency L Tan, JA Dickens, DL DeMeo, E Miranda, J Perez, ST Rashid, J Day, ... European Respiratory Journal 43 (5), 1501-1504, 2014 | 82 | 2014 |
hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency CP Segeritz, ST Rashid, MC de Brito, MP Serra, A Ordonez, CM Morell, ... Journal of hepatology 69 (4), 851-860, 2018 | 61 | 2018 |
Functional consequences of the prothrombotic SERPINC1 rs2227589 polymorphism on antithrombin levels AI Antón, R Teruel, J Corral, A Minano, I Martínez-Martínez, A Ordóñez, ... haematologica 94 (4), 589, 2009 | 60 | 2009 |
A single-chain variable fragment intrabody prevents intracellular polymerization of Z α1-antitrypsin while allowing its antiproteinase activity A Ordóñez, J Pérez, L Tan, JA Dickens, N Motamedi-Shad, JA Irving, ... The FASEB Journal 29 (6), 2667, 2015 | 58 | 2015 |
Unravelling the twists and turns of the serpinopathies BD Roussel, JA Irving, UI Ekeowa, D Belorgey, I Haq, A Ordóñez, ... The FEBS journal 278 (20), 3859-3867, 2011 | 55 | 2011 |
Development of a small molecule that corrects misfolding and increases secretion of Z α1‐antitrypsin DA Lomas, JA Irving, C Arico‐Muendel, S Belyanskaya, A Brewster, ... EMBO Molecular Medicine 13 (3), e13167, 2021 | 51 | 2021 |
Antithrombin Cambridge II (A384S) supports a role for antithrombin deficiency in arterial thrombosis V Roldán, A Ordoñez, F Marín, E Zorio, JM Soria, A Miñano, F España, ... Thrombosis and haemostasis 101 (03), 483-486, 2009 | 51 | 2009 |
AB0 blood group and risk of venous or arterial thrombosis in carriers of factor V Leiden or prothrombin G20210A polymorphisms. A Miñano, A Ordóñez, F España, JR González-Porras, R Lecumberri, ... Ferrata Storti Foundation (Haematologica), 2025 | 50 | 2025 |
p53 and translation attenuation regulate distinct cell cycle checkpoints during endoplasmic reticulum (ER) stress SE Thomas, E Malzer, A Ordoñez, LE Dalton, E Liniker, DC Crowther, ... Journal of Biological Chemistry 288 (11), 7606-7617, 2013 | 50 | 2013 |
Polymers of Z α1-antitrypsin are secreted in cell models of disease. A Fra, F Cosmi, A Ordoñez, R Berardelli, J Perez, NA Guadagno, L Corda, ... European Respiratory Society (ERS), 2016 | 49 | 2016 |
Effect of citrullination on the function and conformation of antithrombin A Ordonez, I Martínez‐Martínez, FJ Corrales, C Miqueo, A Miñano, ... The FEBS Journal 276 (22), 6763-6772, 2009 | 49 | 2009 |
Increased ERK signalling promotes inflammatory signalling in primary airway epithelial cells expressing Z α1-antitrypsin EFA van ‘t Wout, JA Dickens, A van Schadewijk, I Haq, HF Kwok, ... Human Molecular Genetics 23 (4), 929-941, 2014 | 42 | 2014 |
Antithrombin Murcia (K241E) causing antithrombin deficiency: a possible role for altered glycosylation I Martínez-Martínez, A Ordóñez, J Navarro-Fernández, Á Pérez-Lara, ... haematologica 95 (8), 1358, 2010 | 41 | 2010 |
The serpinopathies: studying serpin polymerization in vivo JA Irving, UI Ekeowa, D Belorgey, I Haq, B Gooptu, E Miranda, J Pérez, ... Methods in enzymology 501, 421-466, 2011 | 39 | 2011 |
Poly (ADP-ribose) polymerase-1 inhibition increases expression of heat shock proteins and attenuates heat stroke-induced liver injury RA Mota, D Hernández-Espinosa, L Galbis-Martinez, A Ordoñez, ... Critical care medicine 36 (2), 526-534, 2008 | 36 | 2008 |