Követés
Ashley Pike
Ashley Pike
Centre for Medicines Discovery - University of Oxford
E-mail megerősítve itt: cmd.ox.ac.uk
Cím
Hivatkozott rá
Hivatkozott rá
Év
Molecular basis of agonism and antagonism in the oestrogen receptor
AM Brzozowski, ACW Pike, Z Dauter, RE Hubbard, T Bonn, O Engström, ...
Nature 389 (6652), 753-758, 1997
41791997
Estrogen receptors: how do they signal and what are their targets
N Heldring, A Pike, S Andersson, J Matthews, G Cheng, J Hartman, ...
Physiological reviews 87 (3), 905-931, 2007
23842007
Structure of the ligand‐binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist
ACW Pike, AM Brzozowski, RE Hubbard, T Bonn, AG Thorsell, ...
The EMBO journal, 1999
13131999
Structural insights into the mode of action of a pure antiestrogen
ACW Pike, AM Brzozowski, J Walton, RE Hubbard, AG Thorsell, YL Li, ...
Structure 9 (2), 145-153, 2001
4762001
K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac
YY Dong, ACW Pike, A Mackenzie, C McClenaghan, P Aryal, L Dong, ...
Science 347 (6227), 1256-1259, 2015
3392015
Structural basis for Cul3 protein assembly with the BTB-Kelch family of E3 ubiquitin ligases
P Canning, CDO Cooper, T Krojer, JW Murray, ACW Pike, A Chaikuad, ...
Journal of Biological Chemistry 288 (11), 7803-7814, 2013
3162013
Structure of the CaMKIIδ/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation
P Rellos, ACW Pike, FH Niesen, E Salah, WH Lee, F Von Delft, S Knapp
PLoS biology 8 (7), e1000426, 2010
2922010
Structures of ABCB10, a human ATP-binding cassette transporter in apo-and nucleotide-bound states
CA Shintre, ACW Pike, Q Li, JI Kim, AJ Barr, S Goubin, L Shrestha, J Yang, ...
Proceedings of the National Academy of Sciences 110 (24), 9710-9715, 2013
2892013
Crystal structures of guinea-pig, goat and bovine α-lactalbumin highlight the enhanced conformational flexibility of regions that are significant for its action in lactose synthase
ACW Pike, K Brew, KR Acharya
Structure 4 (6), 691-703, 1996
2691996
A structural biologist's view of the oestrogen receptor
ACW Pike, AM Brzozowski, RE Hubbard
The Journal of steroid biochemistry and molecular biology 74 (5), 261-268, 2000
2272000
Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2)
M Grieben, ACW Pike, CA Shintre, E Venturi, S El-Ajouz, A Tessitore, ...
Nature structural & molecular biology 24 (2), 114-122, 2017
2122017
Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor α
A Wärnmark, E Treuter, JÅ Gustafsson, RE Hubbard, AM Brzozowski, ...
Journal of Biological Chemistry 277 (24), 21862-21868, 2002
2122002
Structure of human factor VIIa and its implications for the triggering of blood coagulation
ACW Pike, AM Brzozowski, SM Roberts, OH Olsen, E Persson
Proceedings of the National Academy of Sciences 96 (16), 8925-8930, 1999
2081999
Activation segment dimerization: a mechanism for kinase autophosphorylation of non‐consensus sites
ACW Pike, P Rellos, FH Niesen, A Turnbull, AW Oliver, SA Parker, ...
The EMBO journal 27 (4), 704-714, 2008
1852008
Structure and regulation of the human Nek2 centrosomal kinase
P Rellos, FJ Ivins, JE Baxter, A Pike, TJ Nott, DM Parkinson, S Das, ...
Journal of Biological Chemistry 282 (9), 6833-6842, 2007
1532007
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K
SR Bushell, ACW Pike, ME Falzone, NJG Rorsman, CM Ta, RA Corey, ...
Nature communications 10 (1), 3956, 2019
1492019
Distinct recognition modes of FXXLF and LXXLL motifs by the androgen receptor
HJ Dubbink, R Hersmus, CS Verma, HAGM van der Korput, ...
Molecular endocrinology 18 (9), 2132-2150, 2004
1462004
Lessons learnt from structural studies of the oestrogen receptor
ACW Pike
Best Practice & Research Clinical Endocrinology & Metabolism 20 (1), 1-14, 2006
1442006
Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2
M Wilkes, MG Madej, L Kreuter, D Rhinow, V Heinz, S De Sanctis, ...
Nature structural & molecular biology 24 (2), 123-130, 2017
1412017
Structure of the human RECQ1 helicase reveals a putative strand-separation pin
ACW Pike, B Shrestha, V Popuri, N Burgess-Brown, L Muzzolini, ...
Proceedings of the National Academy of Sciences 106 (4), 1039-1044, 2009
1372009
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