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Stephan G. Zech
Stephan G. Zech
Adresse e-mail validée de amgen.com
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Discovery of a Covalent Inhibitor of KRASG12C (AMG 510) for the Treatment of Solid Tumors
BA Lanman, JR Allen, JG Allen, AK Amegadzie, KS Ashton, SK Booker, ...
Journal of medicinal chemistry 63 (1), 52-65, 2019
5642019
Protein structure determination by high-resolution solid-state NMR spectroscopy: application to microcrystalline ubiquitin
SG Zech, AJ Wand, AE McDermott
Journal of the American Chemical Society 127 (24), 8618-8626, 2005
3012005
EP-2104R: a fibrin-specific gadolinium-Based MRI contrast agent for detection of thrombus
K Overoye-Chan, S Koerner, RJ Looby, AF Kolodziej, SG Zech, Q Deng, ...
Journal of the American Chemical Society 130 (18), 6025-6039, 2008
2632008
Mobocertinib (TAK-788): A Targeted Inhibitor of EGFR Exon 20 Insertion Mutants in Non–Small Cell Lung Cancer
F Gonzalvez, S Vincent, TE Baker, AE Gould, S Li, SD Wardwell, ...
Cancer Discovery 11 (7), 1672-1687, 2021
1442021
Electron transfer in cyanobacterial photosystem I: II. Determination of forward electron transfer rates of site-directed mutants in a putative electron transfer pathway from A0 …
W Xu, PR Chitnis, A Valieva, A Van der Est, K Brettel, M Guergova-Kuras, ...
Journal of Biological Chemistry 278 (30), 27876-27887, 2003
1422003
Pulsed EPR Study of Spin-Coupled Radical Pairs in Photosynthetic Reaction Centers: Measurement of the Distance Between and in Photosystem I and between and in Bacterial …
R Bittl, SG Zech
The Journal of Physical Chemistry B 101 (8), 1429-1436, 1997
1301997
Fragment growing and linking lead to novel nanomolar lactate dehydrogenase inhibitors
A Kohlmann, SG Zech, F Li, T Zhou, RM Squillace, L Commodore, ...
Journal of medicinal chemistry 56 (3), 1023-1040, 2013
1102013
Electron transfer in cyanobacterial photosystem I: I. Physiological and spectroscopic characterization of site-directed mutants in a putative electron transfer pathway from A0 …
W Xu, P Chitnis, A Valieva, A Van der Est, YN Pushkar, M Krzystyniak, ...
Journal of Biological Chemistry 278 (30), 27864-27875, 2003
1092003
Assembly of photosystem I: II. Rubredoxin is required for the in vivo assembly of FX in Synechococcus sp. PCC 7002 as shown by optical and EPR spectroscopy
G Shen, ML Antonkine, A van der Est, IR Vassiliev, K Brettel, R Bittl, ...
Journal of Biological Chemistry 277 (23), 20355-20366, 2002
1092002
Recruitment of a foreign quinone into the A1 site of photosystem I: II. Structural and functional characterization of phylloquinone biosynthetic pathway mutants by electron …
B Zybailov, A Van Der Est, SG Zech, C Teutloff, TW Johnson, G Shen, ...
Journal of Biological Chemistry 275 (12), 8531-8539, 2000
1042000
Pulsed EPR structure analysis of photosystem I single crystals: localization of the phylloquinone acceptor
R Bittl, SG Zech, P Fromme, HT Witt, W Lubitz
Biochemistry 36 (40), 12001-12004, 1997
1011997
Pulsed EPR spectroscopy on short-lived intermediates in photosystem I
R Bittl, SG Zech
Biochimica et Biophysica Acta (BBA)-Bioenergetics 1507 (1-3), 194-211, 2001
982001
A structural model for the charge separated state in Photosystem I from the orientation of the magnetic interaction tensors
SG Zech, W Hofbauer, A Kamlowski, P Fromme, D Stehlik, W Lubitz, ...
The Journal of Physical Chemistry B 104 (41), 9728-9739, 2000
942000
Recruitment of a foreign quinone into the A1 site of photosystem I: in vivo replacement of plastoquinone-9 by media-supplemented naphthoquinones in phylloquinone biosynthetic …
TW Johnson, B Zybailov, AD Jones, R Bittl, S Zech, D Stehlik, JH Golbeck, ...
Journal of Biological Chemistry 276 (43), 39512-39521, 2001
892001
Pulsed EPR measurement of the distance between P680+· and QA−· in photosystem II
SG Zech, J Kurreck, HJ Eckert, G Renger, W Lubitz, R Bittl
FEBS letters 414 (2), 454-456, 1997
821997
Insertional inactivation of the menG gene, encoding 2-phytyl-1, 4-naphthoquinone methyltransferase of Synechocystis sp. PCC 6803, results in the incorporation of 2-phytyl-1, 4 …
Y Sakuragi, B Zybailov, G Shen, AD Jones, PR Chitnis, A van der Est, ...
Biochemistry 41 (1), 394-405, 2002
742002
Protein binding to lanthanide (III) complexes can reduce the water exchange rate at the lanthanide
SG Zech, HB Eldredge, MP Lowe, P Caravan
Inorganic chemistry 46 (9), 3576-3584, 2007
702007
Pulsed EPR experiments on radical pairs in photosynthesis: Comparison of the donor‐acceptor distances in photosystem I and bacterial reaction centers
SG Zech, W Lubitz, R Bittl
Berichte der Bunsengesellschaft für physikalische Chemie 100 (12), 2041-2044, 1996
671996
Characterization of protein− ligand interactions by high-resolution solid-state NMR spectroscopy
SG Zech, E Olejniczak, P Hajduk, J Mack, AE McDermott
Journal of the American Chemical Society 126 (43), 13948-13953, 2004
552004
Probing the water coordination of protein‐targeted MRI contrast agents by pulsed ENDOR spectroscopy
SG Zech, WC Sun, V Jacques, P Caravan, AV Astashkin, AM Raitsimring
ChemPhysChem 6 (12), 2570-2577, 2005
532005
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