| Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone C Prodromou, SM Roe, R O'Brien, JE Ladbury, PW Piper, LH Pearl Cell 90 (1), 65-75, 1997 | 1654 | 1997 |
| Structure and mechanism of the Hsp90 molecular chaperone machinery LH Pearl, C Prodromou Annu. Rev. Biochem. 75 (1), 271-294, 2006 | 1383 | 2006 |
| Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin SM Roe, C Prodromou, R O'Brien, JE Ladbury, PW Piper, LH Pearl Journal of medicinal chemistry 42 (2), 260-266, 1999 | 1252 | 1999 |
| Crystal structure of an Hsp90–nucleotide–p23/Sba1 closed chaperone complex MMU Ali, SM Roe, CK Vaughan, P Meyer, B Panaretou, PW Piper, ... Nature 440 (7087), 1013-1017, 2006 | 1166 | 2006 |
| GSK-3-selective inhibitors derived from Tyrian purple indirubins L Meijer, AL Skaltsounis, P Magiatis, P Polychronopoulos, M Knockaert, ... Chemistry & biology 10 (12), 1255-1266, 2003 | 976 | 2003 |
| ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo B Panaretou, C Prodromou, SM Roe, R O'Brien, JE Ladbury, PW Piper, ... The EMBO journal 17 (16), 4829-4836, 1998 | 938 | 1998 |
| A structural model for the retroviral proteases LH Pearl, WR Taylor Nature 329 (6137), 351-354, 1987 | 910 | 1987 |
| Crystal structure of glycogen synthase kinase 3β: structural basis for phosphate-primed substrate specificity and autoinhibition R Dajani, E Fraser, SM Roe, N Young, V Good, TC Dale, LH Pearl Cell 105 (6), 721-732, 2001 | 884 | 2001 |
| DNA repair, genome stability and cancer: a historical perspective PA Jeggo, LH Pearl, AM Carr Nature Reviews Cancer 16 (1), 35-42, 2016 | 813 | 2016 |
| Activation of the ATPase activity of hsp90 by the stress-regulated cochaperone aha1 B Panaretou, G Siligardi, P Meyer, A Maloney, JK Sullivan, S Singh, ... Molecular cell 10 (6), 1307-1318, 2002 | 656 | 2002 |
| The ATPase cycle of Hsp90 drives a molecular ‘clamp’via transient dimerization of the N‐terminal domains C Prodromou, B Panaretou, S Chohan, G Siligardi, R O'Brien, JE Ladbury, ... The EMBO journal, 2000 | 648 | 2000 |
| Structural and functional analysis of the middle segment of hsp90: implications for ATP hydrolysis and client protein and cochaperone interactions P Meyer, C Prodromou, B Hu, C Vaughan, SM Roe, B Panaretou, ... Molecular cell 11 (3), 647-658, 2003 | 609 | 2003 |
| Therapeutic opportunities within the DNA damage response LH Pearl, AC Schierz, SE Ward, B Al-Lazikani, FMG Pearl Nature Reviews Cancer 15 (3), 166-180, 2015 | 560 | 2015 |
| Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)‐domain co‐chaperones C Prodromou, G Siligardi, R O'Brien, DN Woolfson, L Regan, B Panaretou, ... The EMBO journal, 1999 | 559 | 1999 |
| NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis SA Eccles, A Massey, FI Raynaud, SY Sharp, G Box, M Valenti, ... Cancer research 68 (8), 2850-2860, 2008 | 553 | 2008 |
| The Hsp90 molecular chaperone: an open and shut case for treatment LH Pearl, C Prodromou, P Workman Biochemical Journal 410 (3), 439-453, 2008 | 550 | 2008 |
| The structural basis of specific base-excision repair by uracil–DNA glycosylase R Savva, K McAuley-Hecht, T Brown, L Pearl Nature 373 (6514), 487-493, 1995 | 525 | 1995 |
| 4, 5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer PA Brough, W Aherne, X Barril, J Borgognoni, K Boxall, JE Cansfield, ... Journal of medicinal chemistry 51 (2), 196-218, 2008 | 520 | 2008 |
| Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases P Polychronopoulos, P Magiatis, AL Skaltsounis, V Myrianthopoulos, ... Journal of medicinal chemistry 47 (4), 935-946, 2004 | 492 | 2004 |
| Structure and function in the uracil-DNA glycosylase superfamily LH Pearl Mutation Research/DNA Repair 460 (3-4), 165-181, 2000 | 492 | 2000 |
