Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review L Schiffer, L Barnard, ES Baranowski, LC Gilligan, AE Taylor, W Arlt, ... The Journal of steroid biochemistry and molecular biology 194, 105439, 2019 | 351 | 2019 |
11-Oxygenated C19 steroids are the predominant androgens in polycystic ovary syndrome MW O’Reilly, P Kempegowda, C Jenkinson, AE Taylor, JL Quanson, ... The Journal of Clinical Endocrinology & Metabolism 102 (3), 840-848, 2017 | 300 | 2017 |
Intracrine androgen biosynthesis, metabolism and action revisited L Schiffer, W Arlt, KH Storbeck Molecular and cellular endocrinology 465, 4-26, 2018 | 215 | 2018 |
11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: a putative role in castration resistant prostate cancer? KH Storbeck, LM Bloem, D Africander, L Schloms, P Swart, AC Swart Molecular and cellular endocrinology 377 (1-2), 135-146, 2013 | 202 | 2013 |
A new dawn for androgens: novel lessons from 11-oxygenated C19 steroids E Pretorius, W Arlt, KH Storbeck Molecular and cellular endocrinology 441, 76-85, 2017 | 154 | 2017 |
11-Ketotestosterone and 11-ketodihydrotestosterone in castration resistant prostate cancer: potent androgens which can no longer be ignored E Pretorius, DJ Africander, M Vlok, MS Perkins, J Quanson, KH Storbeck PloS one 11 (7), e0159867, 2016 | 149 | 2016 |
Steroid metabolome analysis in disorders of adrenal steroid biosynthesis and metabolism KH Storbeck, L Schiffer, ES Baranowski, V Chortis, A Prete, L Barnard, ... Endocrine reviews 40 (6), 1605-1625, 2019 | 127 | 2019 |
The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: quantification of steroid intermediates and end products in H295R cells L Schloms, KH Storbeck, P Swart, WCA Gelderblom, AC Swart The Journal of steroid biochemistry and molecular biology 128 (3-5), 128-138, 2012 | 117 | 2012 |
11β-Hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione AC Swart, L Schloms, KH Storbeck, LM Bloem, T du Toit, JL Quanson, ... The Journal of steroid biochemistry and molecular biology 138, 132-142, 2013 | 110 | 2013 |
High-throughput analysis of 19 endogenous androgenic steroids by ultra-performance convergence chromatography tandem mass spectrometry JL Quanson, MA Stander, E Pretorius, C Jenkinson, AE Taylor, ... Journal of Chromatography B 1031, 131-138, 2016 | 99 | 2016 |
11β-Hydroxyandrostenedione: downstream metabolism by 11βHSD, 17βHSD and SRD5A produces novel substrates in familiar pathways AC Swart, KH Storbeck Molecular and cellular endocrinology 408, 114-123, 2015 | 73 | 2015 |
Modified-release and conventional glucocorticoids and diurnal androgen excretion in congenital adrenal hyperplasia CM Jones, A Mallappa, N Reisch, N Nikolaou, N Krone, BA Hughes, ... The Journal of Clinical Endocrinology & Metabolism 102 (6), 1797-1806, 2017 | 72 | 2017 |
The role of adrenal derived androgens in castration resistant prostate cancer M Barnard, EA Mostaghel, RJ Auchus, KH Storbeck The Journal of steroid biochemistry and molecular biology 197, 105506, 2020 | 70 | 2020 |
11-Oxygenated androgen precursors are the preferred substrates for aldo-keto reductase 1C3 (AKR1C3): implications for castration resistant prostate cancer M Barnard, JL Quanson, E Mostaghel, E Pretorius, JL Snoep, ... The Journal of steroid biochemistry and molecular biology 183, 192-201, 2018 | 69 | 2018 |
11β-hydroxyandrostenedione returns to the steroid arena: biosynthesis, metabolism and function LM Bloem, KH Storbeck, L Schloms, AC Swart Molecules 18 (11), 13228-13244, 2013 | 67 | 2013 |
A comparative study of the androgenic properties of progesterone and the progestins, medroxyprogesterone acetate (MPA) and norethisterone acetate (NET-A) DJ Africander, KH Storbeck, JP Hapgood The Journal of steroid biochemistry and molecular biology 143, 404-415, 2014 | 65 | 2014 |
Advances in the analytical methodologies: Profiling steroids in familiar pathways-challenging dogmas LM Bloem, KH Storbeck, P Swart, T du Toit, L Schloms, AC Swart The Journal of Steroid Biochemistry and Molecular Biology 153, 80-92, 2015 | 61 | 2015 |
11βHSD1 inhibition with AZD4017 improves lipid profiles and lean muscle mass in idiopathic intracranial hypertension RS Hardy, H Botfield, K Markey, JL Mitchell, Z Alimajstorovic, ... The Journal of Clinical Endocrinology & Metabolism 106 (1), 174-187, 2021 | 57 | 2021 |
The utility of ultra-high performance supercritical fluid chromatography–tandem mass spectrometry (UHPSFC-MS/MS) for clinically relevant steroid analysis KH Storbeck, L Gilligan, C Jenkinson, ES Baranowski, JL Quanson, W Arlt, ... Journal of Chromatography B 1085, 36-41, 2018 | 55 | 2018 |
A single amino acid residue, Ala 105, confers 16α-hydroxylase activity to human cytochrome P450 17α-hydroxylase/17, 20 lyase AC Swart, KH Storbeck, P Swart The Journal of steroid biochemistry and molecular biology 119 (3-5), 112-120, 2010 | 53 | 2010 |