| Tau protein aggregation is associated with cellular senescence in the brain N Musi, JM Valentine, KR Sickora, E Baeuerle, CS Thompson, Q Shen, ... Aging cell 17 (6), e12840, 2018 | 504 | 2018 |
| A brief overview of tauopathy: causes, consequences, and therapeutic strategies ME Orr, AC Sullivan, B Frost Trends in pharmacological sciences 38 (7), 637-648, 2017 | 260 | 2017 |
| Autophagic/lysosomal dysfunction in Alzheimer’s disease ME Orr, S Oddo Alzheimer's research & therapy 5, 1-9, 2013 | 209 | 2013 |
| Biological aging processes underlying cognitive decline and neurodegenerative disease MM Gonzales, VR Garbarino, E Pollet, JP Palavicini, DL Kellogg, E Kraig, ... The Journal of clinical investigation 132 (10), 2022 | 180 | 2022 |
| Senolytic therapy to modulate the progression of Alzheimer’s disease (SToMP-AD): a pilot clinical trial MM Gonzales, VR Garbarino, EM Zilli, RC Petersen, JL Kirkland, ... The journal of prevention of Alzheimer's disease, 1-8, 2022 | 126 | 2022 |
| Mechanisms of oxidative stress resistance in the brain: lessons learned from hypoxia tolerant extremophilic vertebrates VR Garbarino, ME Orr, KA Rodriguez, R Buffenstein Archives of biochemistry and biophysics 576, 8-16, 2015 | 113 | 2015 |
| Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial MM Gonzales, VR Garbarino, TF Kautz, JP Palavicini, M Lopez-Cruzan, ... Nature medicine 29 (10), 2481-2488, 2023 | 85 | 2023 |
| Mammalian target of rapamycin hyperactivity mediates the detrimental effects of a high sucrose diet on Alzheimer's disease pathology ME Orr, A Salinas, R Buffenstein, S Oddo Neurobiology of aging 35 (6), 1233-1242, 2014 | 85 | 2014 |
| Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology SK Dehkordi, J Walker, E Sah, E Bennett, F Atrian, B Frost, B Woost, ... Nature aging 1 (12), 1107-1116, 2021 | 84 | 2021 |
| Familial dysautonomia model reveals Ikbkap deletion causes apoptosis of Pax3+ progenitors and peripheral neurons L George, M Chaverra, L Wolfe, J Thorne, M Close-Davis, A Eibs, ... Proceedings of the National Academy of Sciences 110 (46), 18698-18703, 2013 | 79 | 2013 |
| Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity JC Triplett, A Tramutola, A Swomley, J Kirk, K Grimes, K Lewis, M Orr, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1852 (10 …, 2015 | 76 | 2015 |
| The landscape of human tissue and cell type specific expression and co-regulation of senescence genes P Xu, M Wang, W Song, Q Wang, GC Yuan, PH Sudmant, H Zare, Z Tu, ... Molecular neurodegeneration 17, 1-20, 2022 | 71 | 2022 |
| The role of FLO11 in Saccharomyces cerevisiae biofilm development in a laboratory based flow-cell system B Purevdorj-Gage, ME Orr, P Stoodley, KB Sheehan, LE Hyman FEMS yeast research 7 (3), 372-379, 2007 | 62 | 2007 |
| Guidelines for bioinformatics of single-cell sequencing data analysis in Alzheimer’s disease: review, recommendation, implementation and application M Wang, W Song, C Ming, Q Wang, X Zhou, P Xu, A Krek, Y Yoon, L Ho, ... Molecular neurodegeneration 17 (1), 17, 2022 | 60 | 2022 |
| Extended postnatal brain development in the longest-lived rodent: prolonged maintenance of neotenous traits in the naked mole-rat brain ME Orr, VR Garbarino, A Salinas, R Buffenstein Frontiers in neuroscience 10, 504, 2016 | 55 | 2016 |
| Pathogenic tau accelerates aging-associated activation of transposable elements in the mouse central nervous system P Ramirez, G Zuniga, W Sun, A Beckmann, E Ochoa, SL DeVos, B Hyman, ... Progress in neurobiology 208, 102181, 2022 | 54 | 2022 |
| Accumulation of C-terminal fragments of transactive response DNA-binding protein 43 leads to synaptic loss and cognitive deficits in human TDP-43 transgenic mice DX Medina, ME Orr, S Oddo Neurobiology of aging 35 (1), 79-87, 2014 | 54 | 2014 |
| The cellular senescence stress response in post-mitotic brain cells: cell survival at the expense of tissue degeneration E Sah, S Krishnamurthy, MY Ahmidouch, GJ Gillispie, C Milligan, ME Orr Life 11 (3), 229, 2021 | 52 | 2021 |
| Can oral health and oral‐derived biospecimens predict progression of dementia? ME Orr, KR Reveles, CK Yeh, EH Young, X Han Oral diseases 26 (2), 249-258, 2020 | 40 | 2020 |
| Mammalian target of rapamycin at the crossroad between Alzheimer’s disease and diabetes H Liang, J Nie, CE Van Skike, JM Valentine, ME Orr Diabetes Mellitus: A risk factor for Alzheimer's Disease, 185-225, 2019 | 37 | 2019 |