| A landscape of driver mutations in melanoma E Hodis, IR Watson, GV Kryukov, ST Arold, M Imielinski, JP Theurillat, ... Cell 150 (2), 251-263, 2012 | 3041 | 2012 |
| Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone C Prodromou, SM Roe, R O'Brien, JE Ladbury, PW Piper, LH Pearl Cell 90 (1), 65-75, 1997 | 1654 | 1997 |
| Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin SM Roe, C Prodromou, R O'Brien, JE Ladbury, PW Piper, LH Pearl Journal of medicinal chemistry 42 (2), 260-266, 1999 | 1252 | 1999 |
| ATP binding and hydrolysis are essential to the function of the Hsp90 molecular chaperone in vivo B Panaretou, C Prodromou, SM Roe, R O'Brien, JE Ladbury, PW Piper, ... The EMBO journal 17 (16), 4829-4836, 1998 | 938 | 1998 |
| Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation T Spivak-Kroizman, MA Lemmon, I Dikic, JE Ladbury, D Pinchasi, ... Cell 79 (6), 1015-1024, 1994 | 916 | 1994 |
| Microscale thermophoresis quantifies biomolecular interactions under previously challenging conditions SAI Seidel, PM Dijkman, WA Lea, G van den Bogaart, ... Methods 59 (3), 301-315, 2013 | 739 | 2013 |
| Just add water! The effect of water on the specificity of protein-ligand binding sites and its potential application to drug design JE Ladbury Chemistry & biology 3 (12), 973-980, 1996 | 671 | 1996 |
| The ATPase cycle of Hsp90 drives a molecular ‘clamp’via transient dimerization of the N‐terminal domains C Prodromou, B Panaretou, S Chohan, G Siligardi, R O'Brien, JE Ladbury, ... The EMBO journal, 2000 | 648 | 2000 |
| Regulation of Hsp90 ATPase activity by tetratricopeptide repeat (TPR)‐domain co‐chaperones C Prodromou, G Siligardi, R O'Brien, DN Woolfson, L Regan, B Panaretou, ... The EMBO journal, 1999 | 559 | 1999 |
| Sensing the heat: the application of isothermal titration calorimetry to thermodynamic studies of biomolecular interactions JE Ladbury, BZ Chowdhry Chemistry & biology 3 (10), 791-801, 1996 | 529 | 1996 |
| Two EGF molecules contribute additively to stabilization of the EGFR dimer MA Lemmon, Z Bu, JE Ladbury, M Zhou, D Pinchasi, I Lax, DM Engelman, ... The EMBO journal, 1997 | 503 | 1997 |
| Adding calorimetric data to decision making in lead discovery: a hot tip JE Ladbury, G Klebe, E Freire Nature reviews Drug discovery 9 (1), 23-27, 2010 | 480 | 2010 |
| Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression CH Chan, JK Morrow, CF Li, Y Gao, G Jin, A Moten, LJ Stagg, JE Ladbury, ... Cell 154 (3), 556-568, 2013 | 407 | 2013 |
| TCR binding to peptide-MHC stabilizes a flexible recognition interface BE Willcox, GF Gao, JR Wyer, JE Ladbury, JI Bell, BK Jakobsen, ... Immunity 10 (3), 357-365, 1999 | 389 | 1999 |
| Structure and interactions of the human programmed cell death 1 receptor X Cheng, V Veverka, A Radhakrishnan, LC Waters, FW Muskett, ... Journal of Biological Chemistry 288 (17), 11771-11785, 2013 | 371 | 2013 |
| Specific binding of Hoechst 33258 to the d (CGCAAATTTGCG) 2 duplex: calorimetric and spectroscopic studies I Haq, JE Ladbury, BZ Chowdhry, TC Jenkins, JB Chaires Journal of molecular biology 271 (2), 244-257, 1997 | 370 | 1997 |
| The thermodynamics of protein–ligand interaction and solvation: insights for ligand design TSG Olsson, MA Williams, WR Pitt, JE Ladbury Journal of molecular biology 384 (4), 1002-1017, 2008 | 366 | 2008 |
| Measurement of the binding of tyrosyl phosphopeptides to SH2 domains: a reappraisal. JE Ladbury, MA Lemmon, M Zhou, J Green, MC Botfield, J Schlessinger Proceedings of the National Academy of Sciences 92 (8), 3199-3203, 1995 | 344 | 1995 |
| A thermodynamic study of the trp repressor—operator interaction JE Ladbury, JG Wright, JM Sturtevant, PB Sigler Journal of molecular biology 238 (5), 669-681, 1994 | 269 | 1994 |
| TH17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26 S Meller, J Di Domizio, KS Voo, HC Friedrich, G Chamilos, D Ganguly, ... Nature immunology 16 (9), 970-979, 2015 | 262 | 2015 |
