The development of chronic critical illness determines physical function, quality of life, and long-term survival among early survivors of sepsis in surgical ICUs AK Gardner, GL Ghita, Z Wang, T Ozrazgat-Baslanti, SL Raymond, ... Critical care medicine 47 (4), 566-573, 2019 | 144 | 2019 |
Evidence for persistent immune suppression in patients who develop chronic critical illness after sepsis JA Stortz, TJ Murphy, SL Raymond, JC Mira, R Ungaro, ML Dirain, ... Shock 49 (3), 249-258, 2018 | 131 | 2018 |
Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients JA Stortz, JC Mira, SL Raymond, TJ Loftus, T Ozrazgat-Baslanti, Z Wang, ... Journal of Trauma and Acute Care Surgery 84 (2), 342-349, 2018 | 117 | 2018 |
The epidemiology of chronic critical illness after severe traumatic injury at two level–one trauma centers JC Mira, J Cuschieri, T Ozrazgat-Baslanti, Z Wang, GL Ghita, TJ Loftus, ... Critical care medicine 45 (12), 1989-1996, 2017 | 108 | 2017 |
Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis MKK Hollen, JA Stortz, D Darden, ML Dirain, DC Nacionales, RB Hawkins, ... Critical Care 23, 1-16, 2019 | 78 | 2019 |
Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients TJ Loftus, JC Mira, T Ozrazgat-Baslanti, GL Ghita, Z Wang, JA Stortz, ... BMJ open 7 (7), e015136, 2017 | 72 | 2017 |
The impact of age on the innate immune response and outcomes after severe sepsis/septic shock in trauma and surgical intensive care unit patients SC Brakenridge, PA Efron, JA Stortz, T Ozrazgat-Baslanti, G Ghita, ... Journal of Trauma and Acute Care Surgery 85 (2), 247-255, 2018 | 56 | 2018 |
The impact of sarcopenia and acute muscle mass loss on long‐term outcomes in critically ill patients with intra‐abdominal sepsis MC Cox, M Booth, G Ghita, Z Wang, A Gardner, RB Hawkins, DB Darden, ... Journal of cachexia, sarcopenia and muscle 12 (5), 1203-1213, 2021 | 53 | 2021 |
Old mice demonstrate organ dysfunction as well as prolonged inflammation, immunosuppression, and weight loss in a modified surgical sepsis model JA Stortz, MKK Hollen, DC Nacionales, H Horiguchi, R Ungaro, ML Dirain, ... Critical care medicine 47 (11), e919-e929, 2019 | 37 | 2019 |
Cell-free nuclear, but not mitochondrial, DNA concentrations correlate with the early host inflammatory response after severe trauma JA Stortz, RB Hawkins, DC Holden, SL Raymond, Z Wang, ... Scientific reports 9 (1), 13648, 2019 | 37 | 2019 |
Persistent inflammation and anemia among critically ill septic patients TJ Loftus, JC Mira, JA Stortz, T Ozrazgat-Baslanti, GL Ghita, Z Wang, ... Journal of Trauma and Acute Care Surgery 86 (2), 260-267, 2019 | 37 | 2019 |
Chronic critical illness patients fail to respond to current evidence‐based intensive care nutrition secondarily to persistent inflammation, immunosuppression, and catabolic … MD Rosenthal, T Bala, Z Wang, T Loftus, F Moore Journal of Parenteral and Enteral Nutrition 44 (7), 1237-1249, 2020 | 31 | 2020 |
Prospective validation of a transcriptomic metric in severe trauma SL Raymond, RB Hawkins, Z Wang, JC Mira, JA Stortz, F Han, JD Lanz, ... Annals of surgery 271 (5), 802-810, 2020 | 31 | 2020 |
Baricitinib in juvenile idiopathic arthritis: an international, phase 3, randomised, double-blind, placebo-controlled, withdrawal, efficacy, and safety trial AV Ramanan, P Quartier, N Okamoto, I Foeldvari, A Spindler, ... The Lancet 402 (10401), 555-570, 2023 | 23 | 2023 |
Delayed interhospital transfer of critically ill patients with surgical sepsis TJ Loftus, Q Wu, Z Wang, N Lysak, FA Moore, A Bihorac, PA Efron, ... Journal of Trauma and Acute Care Surgery 88 (1), 169-175, 2020 | 22 | 2020 |
Distinct immunologic endotypes are associated with clinical trajectory after severe blunt trauma and hemorrhagic shock SC Brakenridge, Z Wang, M Cox, S Raymond, R Hawkins, D Darden, ... Journal of Trauma and Acute Care Surgery 90 (2), 257-267, 2021 | 20 | 2021 |
Persistently increased cell-free DNA concentrations only modestly contribute to outcome and host response in sepsis survivors with chronic critical illness RB Hawkins, JA Stortz, DC Holden, Z Wang, SL Raymond, MC Cox, ... Surgery 167 (3), 646-652, 2020 | 14 | 2020 |
Identification of unique mRNA and miRNA expression patterns in bone marrow hematopoietic stem and progenitor cells after trauma in older adults DB Darden, JA Stortz, MKK Hollen, MC Cox, CG Apple, RB Hawkins, ... Frontiers in Immunology 11, 1289, 2020 | 11 | 2020 |
Chronic critical illness elicits a unique circulating leukocyte transcriptome in sepsis survivors DB Darden, GL Ghita, Z Wang, JA Stortz, MC Lopez, MC Cox, ... Journal of Clinical Medicine 10 (15), 3211, 2021 | 9 | 2021 |
Transcriptomic responses from improved murine sepsis models can better mimic human surgical sepsis PA Efron, DB Darden, Z Wang, DC Nacionales, MC Lopez, RB Hawkins, ... FASEB journal: official publication of the Federation of American Societies …, 2020 | 8 | 2020 |