Suivre
Juan Troncoso
Juan Troncoso
Professor of Pathology, Johns Hopkins University School of Medicine
Adresse e-mail validée de jhmi.edu
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Année
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
BW Kunkle, B Grenier-Boley, R Sims, JC Bis, V Damotte, AC Naj, ...
Nature genetics 51 (3), 414-430, 2019
26792019
Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature
PT Nelson, I Alafuzoff, EH Bigio, C Bouras, H Braak, NJ Cairns, ...
Journal of Neuropathology & Experimental Neurology 71 (5), 362-381, 2012
23712012
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease
AC Naj, G Jun, GW Beecham, LS Wang, BN Vardarajan, J Buros, ...
Nature genetics 43 (5), 436-441, 2011
22622011
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
MJ West, PD Coleman, DG Flood, JC Troncoso
The lancet 344 (8925), 769-772, 1994
16481994
Primary age-related tauopathy (PART): a common pathology associated with human aging
JF Crary, JQ Trojanowski, JA Schneider, JF Abisambra, EL Abner, ...
Acta neuropathologica 128, 755-766, 2014
14852014
Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity
FC Nucifora Jr, M Sasaki, MF Peters, H Huang, JK Cooper, M Yamada, ...
Science 291 (5512), 2423-2428, 2001
13372001
Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease
RG Cutler, J Kelly, K Storie, WA Pedersen, A Tammara, K Hatanpaa, ...
Proceedings of the National Academy of Sciences 101 (7), 2070-2075, 2004
13262004
C9orf72 nucleotide repeat structures initiate molecular cascades of disease
AR Haeusler, CJ Donnelly, G Periz, EAJ Simko, PG Shaw, MS Kim, ...
Nature 507 (7491), 195-200, 2014
10922014
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
R Sims, SJ Van Der Lee, AC Naj, C Bellenguez, N Badarinarayan, ...
Nature genetics 49 (9), 1373-1384, 2017
10172017
Endocytic pathway abnormalities precede amyloid β deposition in sporadic Alzheimer’s disease and Down syndrome: differential effects of APOE genotype and presenilin mutations
AM Cataldo, CM Peterhoff, JC Troncoso, T Gomez-Isla, BT Hyman, ...
The American journal of pathology 157 (1), 277-286, 2000
9522000
Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain
JR Gibbs, MP Van Der Brug, DG Hernandez, BJ Traynor, MA Nalls, SL Lai, ...
PLoS genetics 6 (5), e1000952, 2010
9172010
RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia
T Zu, Y Liu, M Bañez-Coronel, T Reid, O Pletnikova, J Lewis, TM Miller, ...
Proceedings of the National Academy of Sciences 110 (51), E4968-E4977, 2013
9092013
S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function
KKK Chung, B Thomas, X Li, O Pletnikova, JC Troncoso, L Marsh, ...
Science 304 (5675), 1328-1331, 2004
9082004
Common genetic variants influence human subcortical brain structures
DP Hibar, JL Stein, ME Renteria, A Arias-Vasquez, S Desrivières, ...
Nature 520 (7546), 224-229, 2015
9032015
Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation
ECB Johnson, EB Dammer, DM Duong, L Ping, M Zhou, L Yin, ...
Nature medicine 26 (5), 769-780, 2020
8132020
Genetic variability in the regulation of gene expression in ten regions of the human brain
A Ramasamy, D Trabzuni, S Guelfi, V Varghese, C Smith, R Walker, T De, ...
Nature neuroscience 17 (10), 1418-1428, 2014
7292014
Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease
CI Sze, JC Troncoso, C Kawas, P Mouton, DL Price, LJ Martin
Journal of Neuropathology & Experimental Neurology 56 (8), 933-944, 1997
6961997
The transcriptional landscape of age in human peripheral blood
MJ Peters, R Joehanes, LC Pilling, C Schurmann, KN Conneely, J Powell, ...
Nature communications 6 (1), 8570, 2015
6872015
Genome-wide analyses identify KIF5A as a novel ALS gene
A Nicolas, KP Kenna, AE Renton, N Ticozzi, F Faghri, R Chia, ...
Neuron 97 (6), 1267-1288, 2018
6712018
Gene expression changes in the course of normal brain aging are sexually dimorphic
NC Berchtold, DH Cribbs, PD Coleman, J Rogers, E Head, R Kim, ...
Proceedings of the National Academy of Sciences 105 (40), 15605-15610, 2008
6712008
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