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Christina Guzzo
Christina Guzzo
University of Toronto Scarborough
Adresse e-mail validée de utoronto.ca - Page d'accueil
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The IL-12 family of cytokines in infection, inflammation and autoimmune disorders
K Gee, C Guzzo, NF Che Mat, W Ma, A Kumar
Inflammation & Allergy-Drug Targets (Formerly Current Drug Targets …, 2009
5022009
Interleukin-27 induces a STAT1/3-and NF-κB-dependent proinflammatory cytokine profile in human monocytes
C Guzzo, NFC Mat, K Gee
Journal of Biological Chemistry 285 (32), 24404-24411, 2010
1322010
IL-27 enhances LPS-induced proinflammatory cytokine production via upregulation of TLR4 expression and signaling in human monocytes
C Guzzo, A Ayer, S Basta, BW Banfield, K Gee
The Journal of Immunology 188 (2), 864-873, 2012
1272012
Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for Toll-like receptor activation and cellular signaling
S Abdulkhalek, SR Amith, SL Franchuk, P Jayanth, M Guo, T Finlay, ...
Journal of Biological Chemistry 286 (42), 36532-36549, 2011
1152011
Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer
Q Liu, P Acharya, MA Dolan, P Zhang, C Guzzo, J Lu, A Kwon, D Gururani, ...
Nature structural & molecular biology 24 (4), 370-378, 2017
1092017
The incorporation of host proteins into the external HIV-1 envelope
J Burnie, C Guzzo
Viruses 11 (1), 85, 2019
672019
Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing
C Guzzo, D Ichikawa, C Park, D Phillips, Q Liu, P Zhang, A Kwon, H Miao, ...
Science immunology 2 (11), eaam7341, 2017
672017
Interdomain stabilization impairs CD4 binding and improves immunogenicity of the HIV-1 envelope trimer
P Zhang, J Gorman, H Geng, Q Liu, Y Lin, Y Tsybovsky, EP Go, B Dey, ...
Cell Host & Microbe 23 (6), 832-844. e6, 2018
502018
IL-27 enhances LPS-induced IL-1β in human monocytes and murine macrophages
C Petes, C Wynick, C Guzzo, D Mehta, S Logan, BW Banfield, S Basta, ...
Journal of leukocyte biology 102 (1), 83-94, 2017
432017
Tyrosine sulfation in the second variable loop (V2) of HIV-1 gp120 stabilizes V2–V3 interaction and modulates neutralization sensitivity
R Cimbro, TR Gallant, MA Dolan, C Guzzo, P Zhang, Y Lin, H Miao, ...
Proceedings of the National Academy of Sciences 111 (8), 3152-3157, 2014
432014
The CD8-derived chemokine XCL1/lymphotactin is a conformation-dependent, broad-spectrum inhibitor of HIV-1
C Guzzo, J Fox, Y Lin, H Miao, R Cimbro, BF Volkman, AS Fauci, P Lusso
PLoS pathogens 9 (12), e1003852, 2013
432013
Thymoquinone-induced Neu4 sialidase activates NFκB in macrophage cells and pro-inflammatory cytokines in vivo
TM Finlay, S Abdulkhalek, A Gilmour, C Guzzo, P Jayanth, SR Amith, ...
Glycoconjugate journal 27, 583-600, 2010
432010
IL-27 increases BST-2 expression in human monocytes and T cells independently of type I IFN
C Guzzo, M Jung, A Graveline, BW Banfield, K Gee
Scientific reports 2 (1), 974, 2012
412012
Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Gα i …
TM Finlay, P Jayanth, SR Amith, A Gilmour, C Guzzo, K Gee, R Beyaert, ...
Glycoconjugate journal 27, 329-348, 2010
402010
Impact of HIV infection, highly active antiretroviral therapy, and hepatitis C coinfection on serum interleukin-27
C Guzzo, WM Hopman, NFC Mat, W Wobeser, K Gee
Aids 24 (9), 1371-1374, 2010
342010
The TLR2 agonists lipoteichoic acid and Pam3CSK4 induce greater pro-inflammatory responses than inactivated Mycobacterium butyricum
V Gambhir, C Yildiz, R Mulder, S Siddiqui, C Guzzo, M Szewczuk, K Gee, ...
Cellular immunology 280 (1), 101-107, 2012
332012
Engineering metamorphic chemokine lymphotactin/XCL1 into the GAG-binding, HIV-inhibitory dimer conformation
JC Fox, RC Tyler, C Guzzo, RL Tuinstra, FC Peterson, P Lusso, ...
ACS chemical biology 10 (11), 2580-2588, 2015
302015
Interleukin-23-induced interleukin-23 receptor subunit expression is mediated by the Janus kinase/signal transducer and activation of transcription pathway in human CD4 T cells
NF Che Mat, X Zhang, C Guzzo, K Gee
Journal of Interferon & Cytokine Research 31 (4), 363-371, 2011
282011
IL-27-induced gene expression is downregulated in HIV-infected subjects
C Guzzo, WM Hopman, NF Che Mat, W Wobeser, K Gee
Public Library of Science 7 (9), e45706, 2012
212012
Structural determinants for the selective anti-HIV-1 activity of the all-β alternative conformer of XCL1
C Guzzo, JC Fox, H Miao, BF Volkman, P Lusso
Journal of virology 89 (17), 9061-9067, 2015
202015
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