| CRISPR-Cas guides the future of genetic engineering GJ Knott, JA Doudna Science 361 (6405), 866-869, 2018 | 1375 | 2018 |
| Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy P Fozouni, S Son, MD de León Derby, GJ Knott, CN Gray, MV D’Ambrosio, ... Cell 184 (2), 323-333. e9, 2021 | 758 | 2021 |
| CRISPR-CasΦ from huge phages is a hypercompact genome editor P Pausch, B Al-Shayeb, E Bisom-Rapp, CA Tsuchida, Z Li, BF Cress, ... Science 369 (6501), 333-337, 2020 | 488 | 2020 |
| CasX enzymes comprise a distinct family of RNA-guided genome editors JJ Liu, N Orlova, BL Oakes, E Ma, HB Spinner, KLM Baney, J Chuck, ... Nature 566 (7743), 218-223, 2019 | 472 | 2019 |
| Prion-like domains in RNA binding proteins are essential for building subnuclear paraspeckles S Hennig, G Kong, T Mannen, A Sadowska, S Kobelke, A Blythe, GJ Knott, ... Journal of Cell Biology 210 (4), 529-539, 2015 | 333 | 2015 |
| RNA targeting by functionally orthogonal type VI-A CRISPR-Cas enzymes A East-Seletsky, MR O’Connell, D Burstein, GJ Knott, JA Doudna Molecular cell 66 (3), 373-383. e3, 2017 | 310 | 2017 |
| A broad-spectrum inhibitor of CRISPR-Cas9 LB Harrington, KW Doxzen, E Ma, JJ Liu, GJ Knott, A Edraki, B Garcia, ... Cell 170 (6), 1224-1233. e15, 2017 | 289 | 2017 |
| The DBHS proteins SFPQ, NONO and PSPC1: a multipurpose molecular scaffold GJ Knott, CS Bond, AH Fox Nucleic acids research 44 (9), 3989-4004, 2016 | 272 | 2016 |
| NONO detects the nuclear HIV capsid to promote cGAS-mediated innate immune activation X Lahaye, M Gentili, A Silvin, C Conrad, L Picard, M Jouve, E Zueva, ... Cell 175 (2), 488-501. e22, 2018 | 214 | 2018 |
| Accelerated RNA detection using tandem CRISPR nucleases TY Liu, GJ Knott, DCJ Smock, JJ Desmarais, S Son, A Bhuiya, ... Nature chemical biology 17 (9), 982-988, 2021 | 176 | 2021 |
| DNA capture by a CRISPR-Cas9–guided adenine base editor A Lapinaite, GJ Knott, CM Palumbo, E Lin-Shiao, MF Richter, KT Zhao, ... Science 369 (6503), 566-571, 2020 | 166 | 2020 |
| Controlling and enhancing CRISPR systems H Shivram, BF Cress, GJ Knott, JA Doudna Nature chemical biology 17 (1), 10-19, 2021 | 162 | 2021 |
| Guide-bound structures of an RNA-targeting A-cleaving CRISPR–Cas13a enzyme GJ Knott, A East-Seletsky, JC Cofsky, JM Holton, E Charles, ... Nature structural & molecular biology 24 (10), 825-833, 2017 | 162 | 2017 |
| Structures of the CRISPR genome integration complex AV Wright, JJ Liu, GJ Knott, KW Doxzen, E Nogales, JA Doudna Science 357 (6356), 1113-1118, 2017 | 152 | 2017 |
| RNA binding and HEPN-nuclease activation are decoupled in CRISPR-Cas13a A Tambe, A East-Seletsky, GJ Knott, JA Doudna, MR O’Connell Cell Reports 24 (4), 1025-1036, 2018 | 134 | 2018 |
| Broad-spectrum enzymatic inhibition of CRISPR-Cas12a GJ Knott, BW Thornton, MJ Lobba, JJ Liu, B Al-Shayeb, KE Watters, ... Nature structural & molecular biology 26 (4), 315-321, 2019 | 119 | 2019 |
| Machine learning predicts new anti-CRISPR proteins S Eitzinger, A Asif, KE Watters, AT Iavarone, GJ Knott, JA Doudna, ... Nucleic acids research 48 (9), 4698-4708, 2020 | 91 | 2020 |
| Rapid detection of SARS-CoV-2 RNA in saliva via Cas13 SS Chandrasekaran, S Agrawal, A Fanton, AR Jangid, B Charrez, ... Nature biomedical engineering 6 (8), 944-956, 2022 | 86 | 2022 |
| Kinetic analysis of Cas12a and Cas13a RNA-Guided nucleases for development of improved CRISPR-Based diagnostics EA Nalefski, N Patel, PJY Leung, Z Islam, RM Kooistra, I Parikh, E Marion, ... Iscience 24 (9), 2021 | 67 | 2021 |
| CRISPR–Cas9 bends and twists DNA to read its sequence JC Cofsky, KM Soczek, GJ Knott, E Nogales, JA Doudna Nature structural & molecular biology 29 (4), 395-402, 2022 | 55 | 2022 |