| CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models S Lee, NH Varvel, ME Konerth, G Xu, AE Cardona, RM Ransohoff, ... The American journal of pathology 177 (5), 2549-2562, 2010 | 546 | 2010 |
| Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus NH Varvel, JJ Neher, A Bosch, W Wang, RM Ransohoff, RJ Miller, ... Proceedings of the National Academy of Sciences 113 (38), E5665-E5674, 2016 | 367 | 2016 |
| Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells NH Varvel, SA Grathwohl, F Baumann, C Liebig, A Bosch, B Brawek, ... Proceedings of the National Academy of Sciences 109 (44), 18150-18155, 2012 | 288 | 2012 |
| When and how do seizures kill neurons, and is cell death relevant to epileptogenesis? R Dingledine, NH Varvel, FE Dudek Issues in clinical epileptology: a view from the bench, 109-122, 2014 | 246 | 2014 |
| Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models Y Yang, NH Varvel, BT Lamb, K Herrup Journal of Neuroscience 26 (3), 775-784, 2006 | 217 | 2006 |
| Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events K Bhaskar, N Maphis, G Xu, NH Varvel, ON Kokiko-Cochran, JP Weick, ... Neurobiology of disease 62, 273-285, 2014 | 177 | 2014 |
| Aβ oligomers induce neuronal cell cycle events in Alzheimer's disease NH Varvel, K Bhaskar, AR Patil, SW Pimplikar, K Herrup, BT Lamb Journal of Neuroscience 28 (43), 10786-10793, 2008 | 170 | 2008 |
| NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease NH Varvel, K Bhaskar, MZ Kounnas, SL Wagner, Y Yang, BT Lamb, ... The Journal of clinical investigation 119 (12), 3692-3702, 2009 | 148 | 2009 |
| Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease BL Wilkinson, PE Cramer, NH Varvel, E Reed-Geaghan, Q Jiang, ... Neurobiology of Aging 33 (1), 197. e21-197. e32, 2012 | 130 | 2012 |
| The presence of Aβ seeds, and not age per se, is critical to the initiation of Aβ deposition in the brain T Hamaguchi, YS Eisele, NH Varvel, BT Lamb, LC Walker, M Jucker Acta neuropathologica 123, 31-37, 2012 | 121 | 2012 |
| Replacement of brain-resident myeloid cells does not alter cerebral amyloid-β deposition in mouse models of Alzheimer’s disease NH Varvel, SA Grathwohl, K Degenhardt, C Resch, A Bosch, M Jucker, ... Journal of Experimental Medicine 212 (11), 1803-1809, 2015 | 102 | 2015 |
| Candidate drug targets for prevention or modification of epilepsy NH Varvel, J Jiang, R Dingledine Annual review of pharmacology and toxicology 55 (1), 229-247, 2015 | 97 | 2015 |
| The cleavage products of amyloid-β precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites V Muresan, NH Varvel, BT Lamb, Z Muresan Journal of Neuroscience 29 (11), 3565-3578, 2009 | 92 | 2009 |
| The COX-2/prostanoid signaling cascades in seizure disorders A Rojas, D Chen, T Ganesh, NH Varvel, R Dingledine Expert opinion on therapeutic targets 23 (1), 1-13, 2019 | 58 | 2019 |
| 5xFAD mice display sex-dependent inflammatory gene induction during the prodromal stage of Alzheimer’s disease Z Manji, A Rojas, W Wang, R Dingledine, NH Varvel, T Ganesh Journal of Alzheimer's Disease 70 (4), 1259-1274, 2019 | 51 | 2019 |
| Nordihydroguaiaretic acid does not disaggregate β-amyloid (1–40) protofibrils but does inhibit growth arising from direct protofibril association MA Moss, NH Varvel, MR Nichols, DK Reed, TL Rosenberry Molecular pharmacology 66 (3), 592-600, 2004 | 49 | 2004 |
| Photoreceptor degeneration, azoospermia, leukoencephalopathy, and abnormal RPE cell function in mice expressing an early stop mutation in CLCN2 MM Edwards, CM de Evsikova, GB Collin, E Gifford, J Wu, WL Hicks, ... Investigative ophthalmology & visual science 51 (6), 3264-3272, 2010 | 32 | 2010 |
| Progranulin loss results in sex-dependent dysregulation of the peripheral and central immune system MC Houser, O Uriarte Huarte, RL Wallings, CE Keating, KP MacPherson, ... Frontiers in Immunology 13, 1056417, 2022 | 24 | 2022 |
| Peripheral myeloid cell EP2 activation contributes to the deleterious consequences of status epilepticus NH Varvel, C Espinosa-Garcia, S Hunter-Chang, D Chen, A Biegel, ... Journal of Neuroscience 41 (5), 1105-1117, 2021 | 24 | 2021 |
| Preclinical development of an EP2 antagonist for post-seizure cognitive deficits NH Varvel, R Amaradhi, C Espinosa-Garcia, S Duddy, R Franklin, A Banik, ... Neuropharmacology 224, 109356, 2023 | 9 | 2023 |
Bruce LambDirector, Stark Neurosciences Research Institute at Indiana University School of MedicineAdresse e-mail validée de iu.edu
ray dingledineAdresse e-mail validée de pharm.emory.eduRichard M. RansohoffThird Rock VenturesAdresse e-mail validée de thirdrockventures.com
Astrid CardonaThe University of Texas at San Antonio. Molecular Microbiology and ImmunologyAdresse e-mail validée de utsa.edu
Jonas J NeherLMU Munich & German Center for Neurodegenerative Diseases (DZNE)Adresse e-mail validée de dzne.de
Thota GaneshEmory UniversityAdresse e-mail validée de emory.edu
Olga Kokiko-CochranAssistant Professor, The Ohio State UniversityAdresse e-mail validée de osumc.edu
Dr. Frank BaumannHertie Institute for Clinical Brain ResearchAdresse e-mail validée de uni-tuebingen.de
Frank HeppnerDept. of Neuropathology, Charité - Universitätsmedizin BerlinAdresse e-mail validée de charite.de
Sungho LeeLSU Health ShreveportAdresse e-mail validée de lsuhs.edu
Nicole MaphisPostdoctoral Researcher, University of New MexicoAdresse e-mail validée de salud.unm.edu
