Artikkelit, joihin on yleisen käytön mandaatti - Evan PowersLisätietoja
Ei saatavilla missään: 5
Understanding the mechanism of β‐sheet folding from a chemical and biological perspective
M Jager, S Deechongkit, EK Koepf, H Nguyen, J Gao, ET Powers, ...
Peptide Science 90 (6), 751-758, 2008
Mandaatit: US National Institutes of Health
Thermodynamic stability and denaturation kinetics of a benign natural transthyretin mutant identified in a Danish kindred
M Groenning, RI Campos, C Fagerberg, AA Rasmussen, UH Eriksen, ...
Amyloid 18 (2), 35-46, 2011
Mandaatit: Swedish Research Council
Understanding and ameliorating the TTR amyloidoses
SM Johnson, L Wiseman, JF Paulsson, S Choi, ET Powers, JN Buxbaum, ...
Protein Misfolding Diseases: Current and Emerging Principles and Therapies …, 2010
Mandaatit: US National Institutes of Health
From uncovering the mechanism of transthyretin aggregation to the drug tafamidis for ameliorating neurodegeneration and cardiomyopathy
ET Powers, JW Kelly
Neurotherapeutics in the Era of Translational Medicine, 65-103, 2021
Mandaatit: US National Institutes of Health
Biochemistry and Protein Interactions of the CYREN Microprotein
L Xie, ME Bowman, GV Louie, C Zhang, MS Ardejani, X Huang, Q Chu, ...
Biochemistry 62 (21), 3050-3060, 2023
Mandaatit: US National Institutes of Health
Saatavilla jossain: 69
Biological and chemical approaches to diseases of proteostasis deficiency
ET Powers, RI Morimoto, A Dillin, JW Kelly, WE Balch
Annual review of biochemistry 78 (1), 959-991, 2009
Mandaatit: US National Institutes of Health, Howard Hughes Medical Institute
Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade
CE Bulawa, S Connelly, M DeVit, L Wang, C Weigel, JA Fleming, ...
Proceedings of the National Academy of Sciences 109 (24), 9629-9634, 2012
Mandaatit: US National Institutes of Health
Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
M Talantova, S Sanz-Blasco, X Zhang, P Xia, MW Akhtar, S Okamoto, ...
Proceedings of the National Academy of Sciences 110 (27), E2518-E2527, 2013
Mandaatit: US National Institutes of Health, Government of Spain
Amyloid-β forms fibrils by nucleated conformational conversion of oligomers
J Lee, EK Culyba, ET Powers, JW Kelly
Nature chemical biology 7 (9), 602-609, 2011
Mandaatit: US National Institutes of Health
Targeting protein aggregation for the treatment of degenerative diseases
YS Eisele, C Monteiro, C Fearns, SE Encalada, RL Wiseman, ET Powers, ...
Nature reviews Drug discovery 14 (11), 759-780, 2015
Mandaatit: US National Institutes of Health
The transthyretin amyloidoses: from delineating the molecular mechanism of aggregation linked to pathology to a regulatory-agency-approved drug
SM Johnson, S Connelly, C Fearns, ET Powers, JW Kelly
Journal of molecular biology 421 (2-3), 185-203, 2012
Mandaatit: US National Institutes of Health
Diversity in the origins of proteostasis networks—a driver for protein function in evolution
ET Powers, WE Balch
Nature reviews Molecular cell biology 14 (4), 237-248, 2013
Mandaatit: US National Institutes of Health
The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability
SR Hanson, EK Culyba, TL Hsu, CH Wong, JW Kelly, ET Powers
Proceedings of the National Academy of Sciences 106 (9), 3131-3136, 2009
Mandaatit: US National Institutes of Health
“Inverse drug discovery” strategy to identify proteins that are targeted by latent electrophiles as exemplified by aryl fluorosulfates
DE Mortenson, GJ Brighty, L Plate, G Bare, W Chen, S Li, H Wang, ...
Journal of the American Chemical Society 140 (1), 200-210, 2018
Mandaatit: Hewlett Foundation, US National Institutes of Health
Arylfluorosulfates inactivate intracellular lipid binding protein (s) through chemoselective SuFEx reaction with a binding site Tyr residue
W Chen, J Dong, L Plate, DE Mortenson, GJ Brighty, S Li, Y Liu, ...
Journal of the American Chemical Society 138 (23), 7353-7364, 2016
Mandaatit: US Department of Energy, Hewlett Foundation, US National Institutes of Health
Localized thermodynamic coupling between hydrogen bonding and microenvironment polarity substantially stabilizes proteins
J Gao, DA Bosco, ET Powers, JW Kelly
Nature structural & molecular biology 16 (7), 684-690, 2009
Mandaatit: US National Institutes of Health
Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation
L Plate, CB Cooley, JJ Chen, RJ Paxman, CM Gallagher, F Madoux, ...
elife 5, e15550, 2016
Mandaatit: US National Institutes of Health
The intrinsic and extrinsic effects of N-linked glycans on glycoproteostasis
DN Hebert, L Lamriben, ET Powers, JW Kelly
Nature chemical biology 10 (11), 902-910, 2014
Mandaatit: US National Institutes of Health
Protein native-state stabilization by placing aromatic side chains in N-glycosylated reverse turns
EK Culyba, JL Price, SR Hanson, A Dhar, CH Wong, M Gruebele, ...
Science 331 (6017), 571-575, 2011
Mandaatit: US National Institutes of Health
AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin
SC Penchala, S Connelly, Y Wang, MS Park, L Zhao, A Baranczak, ...
Proceedings of the National Academy of Sciences 110 (24), 9992-9997, 2013
Mandaatit: US National Institutes of Health
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