| The FoldX web server: an online force field J Schymkowitz, J Borg, F Stricher, R Nys, F Rousseau, L Serrano Nucleic acids research 33 (suppl_2), W382-W388, 2005 | 2844 | 2005 |
| Protein phase separation: a new phase in cell biology S Boeynaems, S Alberti, NL Fawzi, T Mittag, M Polymenidou, F Rousseau, ... Trends in cell biology 28 (6), 420-435, 2018 | 1919 | 2018 |
| Prediction of sequence-dependent and mutational effects on the aggregation of peptides and proteins AM Fernandez-Escamilla, F Rousseau, J Schymkowitz, L Serrano Nature biotechnology 22 (10), 1302-1306, 2004 | 1833 | 2004 |
| Exploring the sequence determinants of amyloid structure using position-specific scoring matrices S Maurer-Stroh, M Debulpaep, N Kuemmerer, ML De La Paz, IC Martins, ... Nature methods 7 (3), 237-242, 2010 | 745 | 2010 |
| Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio I Kuperstein, K Broersen, I Benilova, J Rozenski, W Jonckheere, ... The EMBO journal 29 (19), 3408-3420, 2010 | 664 | 2010 |
| The mechanism of γ‐secretase dysfunction in familial Alzheimer disease L Chávez‐Gutiérrez, L Bammens, I Benilova, A Vandersteen, M Benurwar, ... The EMBO journal 31 (10), 2261-2274, 2012 | 633 | 2012 |
| Gain of function of mutant p53 by coaggregation with multiple tumor suppressors J Xu, J Reumers, JR Couceiro, F De Smet, R Gallardo, S Rudyak, ... Nature chemical biology 7 (5), 285-295, 2011 | 610 | 2011 |
| Phase separation of C9orf72 dipeptide repeats perturbs stress granule dynamics S Boeynaems, E Bogaert, D Kovacs, A Konijnenberg, E Timmerman, ... Molecular cell 65 (6), 1044-1055. e5, 2017 | 553 | 2017 |
| A comparative study of the relationship between protein structure and β-aggregation in globular and intrinsically disordered proteins R Linding, J Schymkowitz, F Rousseau, F Diella, L Serrano Journal of molecular biology 342 (1), 345-353, 2004 | 479 | 2004 |
| The stability effects of protein mutations appear to be universally distributed N Tokuriki, F Stricher, J Schymkowitz, L Serrano, DS Tawfik Journal of molecular biology 369 (5), 1318-1332, 2007 | 462 | 2007 |
| Protein aggregation and amyloidosis: confusion of the kinds? F Rousseau, J Schymkowitz, L Serrano Current opinion in structural biology 16 (1), 118-126, 2006 | 428 | 2006 |
| Lipids revert inert Aβ amyloid fibrils to neurotoxic protofibrils that affect learning in mice IC Martins, I Kuperstein, H Wilkinson, E Maes, M Vanbrabant, ... The EMBO journal 27 (1), 224-233, 2008 | 405 | 2008 |
| Prediction of water and metal binding sites and their affinities by using the Fold-X force field JWH Schymkowitz, F Rousseau, IC Martins, J Ferkinghoff-Borg, F Stricher, ... Proceedings of the National Academy of Sciences 102 (29), 10147-10152, 2005 | 400 | 2005 |
| A graphical interface for the FoldX forcefield J Van Durme, J Delgado, F Stricher, L Serrano, J Schymkowitz, ... Bioinformatics 27 (12), 1711-1712, 2011 | 350 | 2011 |
| Restricted location of PSEN2/γ-secretase determines substrate specificity and generates an intracellular Aβ pool R Sannerud, C Esselens, P Ejsmont, R Mattera, L Rochin, ... Cell 166 (1), 193-208, 2016 | 341 | 2016 |
| Structural basis for increased toxicity of pathological aβ42: aβ40 ratios in Alzheimer disease K Pauwels, TL Williams, KL Morris, W Jonckheere, A Vandersteen, ... Journal of biological chemistry 287 (8), 5650-5660, 2012 | 301 | 2012 |
| SNPeffect 4.0: on-line prediction of molecular and structural effects of protein-coding variants G De Baets, J Van Durme, J Reumers, S Maurer-Stroh, P Vanhee, ... Nucleic acids research 40 (D1), D935-D939, 2012 | 300 | 2012 |
| Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD S Boeynaems, E Bogaert, E Michiels, I Gijselinck, A Sieben, A Jovičić, ... Scientific reports 6 (1), 20877, 2016 | 295 | 2016 |
| How evolutionary pressure against protein aggregation shaped chaperone specificity F Rousseau, L Serrano, JWH Schymkowitz Journal of molecular biology 355 (5), 1037-1047, 2006 | 293 | 2006 |
| Alzheimer’s-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions M Szaruga, B Munteanu, S Lismont, S Veugelen, K Horré, M Mercken, ... Cell 170 (3), 443-456. e14, 2017 | 268 | 2017 |
Nikolaos LourosAssistant Professor, UT Soutwestern Medical CenterVahvistettu sähköpostiosoite verkkotunnuksessa utsouthwestern.edu