Force triggers YAP nuclear entry by regulating transport across nuclear pores A Elosegui-Artola, I Andreu, AEM Beedle, A Lezamiz, M Uroz, ... Cell 171 (6), 1397-1410. e14, 2017 | 1277 | 2017 |
Steering chemical reactions with force S Garcia-Manyes, AEM Beedle Nature Reviews Chemistry 1 (11), 0083, 2017 | 131 | 2017 |
Mechanical force application to the nucleus regulates nucleocytoplasmic transport I Andreu, I Granero-Moya, NR Chahare, K Clein, M Molina-Jordán, ... Nature cell biology 24 (6), 896-905, 2022 | 96 | 2022 |
The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening I Andreu, B Falcones, S Hurst, N Chahare, X Quiroga, AL Le Roux, ... Nature communications 12 (1), 4229, 2021 | 89 | 2021 |
Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding AEM Beedle, S Lynham, S Garcia-Manyes Nature communications 7 (1), 12490, 2016 | 74 | 2016 |
The mechanochemistry of copper reports on the directionality of unfolding in model cupredoxin proteins AEM Beedle, A Lezamiz, G Stirnemann, S Garcia-Manyes Nature communications 6 (1), 7894, 2015 | 70 | 2015 |
Forcing the reversibility of a mechanochemical reaction AEM Beedle, M Mora, CT Davis, AP Snijders, G Stirnemann, ... Nature Communications 9 (1), 3155, 2018 | 69 | 2018 |
The mechanical stability of proteins regulates their translocation rate into the cell nucleus E Infante, A Stannard, SJ Board, P Rico-Lastres, E Rostkova, AEM Beedle, ... Nature physics 15 (9), 973-981, 2019 | 49 | 2019 |
Single-molecule force spectroscopy predicts a misfolded, domain-swapped conformation in human γD-crystallin protein S Garcia-Manyes, D Giganti, CL Badilla, A Lezamiz, J Perales-Calvo, ... Journal of Biological Chemistry 291 (8), 4226-4235, 2016 | 45 | 2016 |
The laminin–keratin link shields the nucleus from mechanical deformation and signalling Z Kechagia, P Sáez, M Gómez-González, B Canales, S Viswanadha, ... Nature materials 22 (11), 1409-1420, 2023 | 39 | 2023 |
Binding of myomesin to obscurin-like-1 at the muscle M-band provides a strategy for isoform-specific mechanical protection S Pernigo, A Fukuzawa, AEM Beedle, M Holt, A Round, A Pandini, ... Structure 25 (1), 107-120, 2017 | 37 | 2017 |
Tailoring protein nanomechanics with chemical reactivity AEM Beedle, M Mora, S Lynham, G Stirnemann, S Garcia-Manyes Nature Communications 8 (1), 15658, 2017 | 34 | 2017 |
The role of single-protein elasticity in mechanobiology AEM Beedle, S Garcia-Manyes Nature Reviews Materials 8 (1), 10-24, 2023 | 23 | 2023 |
Mechanobiology—chemical origin of membrane mechanical resistance and force-dependent signaling AEM Beedle, A Williams, J Relat-Goberna, S Garcia-Manyes Current opinion in chemical biology 29, 87-93, 2015 | 23 | 2015 |
Molecular fluctuations as a ruler of force-induced protein conformations A Stannard, M Mora, AEM Beedle, M Castro-López, S Board, ... Nano letters 21 (7), 2953-2961, 2021 | 19 | 2021 |
The nanomechanics of lipid multibilayer stacks exhibits complex dynamics J Relat‐Goberna, AEM Beedle, S Garcia‐Manyes small 13 (24), 1700147, 2017 | 17 | 2017 |
The reversibility of cellular mechano-activation AEM Beedle, P Roca-Cusachs Current Opinion in Cell Biology 84, 102229, 2023 | 6 | 2023 |
Mechanosensitivity of nucleocytoplasmic transport I Andreu, I Granero-Moya, NR Chahare, K Clein, MM Jordàn, AEM Beedle, ... bioRxiv, 2021.07. 23.453478, 2021 | 5 | 2021 |
In search of a softer environment AEM Beedle, P Roca-Cusachs Nature Materials 21 (9), 995-996, 2022 | 3 | 2022 |
Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton AEM Beedle, A Jaganathan, A Albajar-Sigales, FM Yavitt, K Bera, ... bioRxiv, 2023 | 1 | 2023 |