| Reaching for high-hanging fruit in drug discovery at protein–protein interfaces JA Wells, CL McClendon Nature 450 (7172), 1001-1009, 2007 | 2374 | 2007 |
| Dynamic architecture of a protein kinase CL McClendon, AP Kornev, MK Gilson, SS Taylor Proceedings of the National Academy of Sciences 111 (43), E4623-E4631, 2014 | 299 | 2014 |
| Quantifying correlations between allosteric sites in thermodynamic ensembles CL McClendon, G Friedland, DL Mobley, H Amirkhani, MP Jacobson Journal of chemical theory and computation 5 (9), 2486-2502, 2009 | 260 | 2009 |
| Turning a protein kinase on or off from a single allosteric site via disulfide trapping JD Sadowsky, MA Burlingame, DW Wolan, CL McClendon, MP Jacobson, ... Proceedings of the National Academy of Sciences 108 (15), 6056-6061, 2011 | 174 | 2011 |
| A dynamic hydrophobic core orchestrates allostery in protein kinases J Kim, LG Ahuja, FA Chao, Y Xia, CL McClendon, AP Kornev, SS Taylor, ... Science advances 3 (4), e1600663, 2017 | 111 | 2017 |
| Comparing conformational ensembles using the Kullback–Leibler divergence expansion CL McClendon, L Hua, G Barreiro, MP Jacobson Journal of chemical theory and computation 8 (6), 2115-2126, 2012 | 94 | 2012 |
| Modeling conformational ensembles of slow functional motions in Pin1-WW F Morcos, S Chatterjee, CL McClendon, PR Brenner, R López-Rendón, ... PLoS computational biology 6 (12), e1001015, 2010 | 89 | 2010 |
| Synchronous opening and closing motions are essential for cAMP-dependent protein kinase A signaling AK Srivastava, LR McDonald, A Cembran, J Kim, LR Masterson, ... Structure 22 (12), 1735-1743, 2014 | 75 | 2014 |
| Discovery of novel 15-lipoxygenase activators to shift the human arachidonic acid metabolic network toward inflammation resolution H Meng, CL McClendon, Z Dai, K Li, X Zhang, S He, E Shang, Y Liu, L Lai Journal of Medicinal Chemistry 59 (9), 4202-4209, 2016 | 62 | 2016 |
| Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer LG Ahuja, AP Kornev, CL McClendon, G Veglia, SS Taylor Proceedings of the National Academy of Sciences 114 (6), E931-E940, 2017 | 59 | 2017 |
| Substrate and inhibitor-induced dimerization and cooperativity in caspase-1 but not caspase-3. D Datta*, CL McClendon*, MP Jacobson, JA Wells The Journal of biological chemistry, 2013 | 51 | 2013 |
| A new coarse-grained model for E. coli cytoplasm: accurate calculation of the diffusion coefficient of proteins and observation of anomalous diffusion S Hasnain, CL McClendon, MT Hsu, MP Jacobson, P Bandyopadhyay PLoS One 9 (9), e106466, 2014 | 47 | 2014 |
| Decoding the interactions regulating the active state mechanics of eukaryotic protein kinases HS Meharena, X Fan, LG Ahuja, MM Keshwani, CL McClendon, AM Chen, ... PLoS Biology 14 (11), e2000127, 2016 | 46 | 2016 |
| Cosolvent-enhanced sampling and unbiased identification of cryptic pockets suitable for structure-based drug design D Schmidt, M Boehm, CL McClendon, R Torella, H Gohlke Journal of chemical theory and computation 15 (5), 3331-3343, 2019 | 35 | 2019 |
| Ensemble-and rigidity theory-based perturbation approach to analyze dynamic allostery C Pfleger, A Minges, M Boehm, CL McClendon, R Torella, H Gohlke Journal of Chemical Theory and Computation 13 (12), 6343-6357, 2017 | 35 | 2017 |
| Conformational Equilibrium of N-Myristoylated cAMP-Dependent Protein Kinase A by Molecular Dynamics Simulations A Cembran, LR Masterson, CL McClendon, SS Taylor, J Gao, G Veglia Biochemistry, 2012 | 34 | 2012 |
| Hydrogen Bond Strengths in Phosphorylated and Sulfated Amino Acid Residues C Rapp, H Klerman, E Levine, CL McClendon PLOS ONE, 2013 | 28 | 2013 |
| Optimized lattice qcd kernels for a pentium 4 cluster C McClendon Thomas Jefferson National Accelerator Facility (TJNAF), Newport News, VA …, 2001 | 28* | 2001 |
| Active site conformational dynamics are coupled to catalysis in the mRNA decapping enzyme Dcp2 RA Aglietti, SN Floor, CL McClendon, MP Jacobson, JD Gross Structure 21 (9), 1571-1580, 2013 | 26 | 2013 |
| Broadening the scope of binding free energy calculations using a Separated Topologies approach HM Baumann, E Dybeck, CL McClendon, FC Pickard IV, V Gapsys, ... Journal of Chemical Theory and Computation 19 (15), 5058-5076, 2023 | 21 | 2023 |
Matthew JacobsonUCSFایمیل تأیید شده در ucsf.edu
