| Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin RK Graham, Y Deng, EJ Slow, B Haigh, N Bissada, G Lu, J Pearson, ... Cell 125 (6), 1179-1191, 2006 | 823 | 2006 |
| Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China F Han, L Lin, SC Warby, J Faraco, J Li, SX Dong, P An, L Zhao, LH Wang, ... Annals of neurology 70 (3), 410-417, 2011 | 568 | 2011 |
| Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease CL Wellington, LM Ellerby, CA Gutekunst, D Rogers, S Warby, ... Journal of Neuroscience 22 (18), 7862-7872, 2002 | 512 | 2002 |
| CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion JM Lee, EM Ramos, JH Lee, T Gillis, JS Mysore, MR Hayden, SC Warby, ... Neurology 78 (10), 690-695, 2012 | 454 | 2012 |
| Sleep-spindle detection: crowdsourcing and evaluating performance of experts, non-experts and automated methods SC Warby, SL Wendt, P Welinder, EGS Munk, O Carrillo, HBD Sorensen, ... Nature methods 11 (4), 385, 2014 | 412 | 2014 |
| Potent and selective antisense oligonucleotides targeting single-nucleotide polymorphisms in the huntington disease gene/allele-specific silencing of mutant Huntingtin JB Carroll, SC Warby, AL Southwell, CN Doty, S Greenlee, N Skotte, ... Molecular Therapy 19 (12), 2178-2185, 2011 | 333 | 2011 |
| CAG expansion in the Huntington disease gene is associated with a specific and targetable predisposing haplogroup SC Warby, A Montpetit, AR Hayden, JB Carroll, SL Butland, H Visscher, ... The American Journal of Human Genetics 84 (3), 351-366, 2009 | 307 | 2009 |
| HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis RR Singaraja, S Hadano, M Metzler, S Givan, CL Wellington, S Warby, ... Human molecular genetics 11 (23), 2815-2828, 2002 | 279 | 2002 |
| Common variants in P2RY11 are associated with narcolepsy BR Kornum, M Kawashima, J Faraco, L Lin, TJ Rico, S Hesselson, ... Nature genetics 43 (1), 66-71, 2011 | 268 | 2011 |
| HTT haplotypes contribute to differences in Huntington disease prevalence between Europe and East Asia SC Warby, H Visscher, JA Collins, CN Doty, C Carter, SL Butland, ... European Journal of Human Genetics 19 (5), 561-566, 2011 | 210 | 2011 |
| Huntington disease SC Warby, RK Graham, MR Hayden GeneReviews at GeneTests: Medical Genetics Information Resource (database …, 2010 | 202* | 2010 |
| Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo SC Warby, EY Chan, M Metzler, L Gan, RR Singaraja, SF Crocker, ... Human molecular genetics 14 (11), 1569-1577, 2005 | 190 | 2005 |
| Predictive testing for Huntington disease: interpretation and significance of intermediate alleles A Semaka, S Creighton, S Warby, MR Hayden Clinical genetics 70 (4), 283-294, 2006 | 181 | 2006 |
| Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain AS Hackam, AS Yassa, R Singaraja, M Metzler, CA Gutekunst, L Gan, ... Journal of Biological Chemistry 275 (52), 41299-41308, 2000 | 175 | 2000 |
| Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus SC Warby, CN Doty, RK Graham, JB Carroll, YZ Yang, RR Singaraja, ... Human molecular genetics 17 (15), 2390-2404, 2008 | 167 | 2008 |
| Allele-specific suppression of mutant huntingtin using antisense oligonucleotides: providing a therapeutic option for all Huntington disease patients NH Skotte, AL Southwell, ME Østergaard, JB Carroll, SC Warby, CN Doty, ... PloS one 9 (9), e107434, 2014 | 165 | 2014 |
| A SNP in the HTT promoter alters NF-κB binding and is a bidirectional genetic modifier of Huntington disease K Bečanović, A Nørremølle, SJ Neal, C Kay, JA Collins, D Arenillas, T Lilja, ... Nature neuroscience 18 (6), 807-816, 2015 | 149 | 2015 |
| Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study DJ Gottlieb, K Hek, TH Chen, NF Watson, G Eiriksdottir, EM Byrne, ... Molecular psychiatry 20 (10), 1232-1239, 2015 | 143 | 2015 |
| Phosphorylation of huntingtin reduces the accumulation of its nuclear fragments SC Warby, CN Doty, RK Graham, J Shively, RR Singaraja, MR Hayden Molecular and Cellular Neuroscience 40 (2), 121-127, 2009 | 132 | 2009 |
| A fully humanized transgenic mouse model of Huntington disease AL Southwell, SC Warby, JB Carroll, CN Doty, NH Skotte, W Zhang, ... Human Molecular Genetics 22 (1), 18-34, 2013 | 130 | 2013 |
Michael HaydenKillam Professor, University of British Columbiaایمیل تأیید شده در cmmt.ubc.ca