| Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway L Sun, J Wu, F Du, X Chen, ZJ Chen Science 339 (6121), 786-791, 2013 | 4509 | 2013 |
| Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-κB and IRF3 RB Seth, L Sun, CK Ea, ZJ Chen Cell 122 (5), 669-682, 2005 | 3874 | 2005 |
| TAK1 is a ubiquitin-dependent kinase of MKK and IKK C Wang, L Deng, M Hong, GR Akkaraju, J Inoue, ZJ Chen Nature 412 (6844), 346-351, 2001 | 2721 | 2001 |
| Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain L Deng, C Wang, E Spencer, L Yang, A Braun, J You, C Slaughter, ... Cell 103 (2), 351-361, 2000 | 2447 | 2000 |
| Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA J Wu, L Sun, X Chen, F Du, H Shi, C Chen, ZJ Chen Science 339 (6121), 826-830, 2013 | 2418 | 2013 |
| TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity MU Gack, YC Shin, CH Joo, T Urano, C Liang, L Sun, O Takeuchi, S Akira, ... Nature 446 (7138), 916-920, 2007 | 1914 | 2007 |
| STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferon-dependent antitumor immunity in immunogenic tumors L Deng, H Liang, M Xu, X Yang, B Burnette, A Arina, XD Li, H Mauceri, ... Immunity 41 (5), 843-852, 2014 | 1872 | 2014 |
| Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing Q Chen, L Sun, ZJ Chen Nature immunology 17 (10), 1142-1149, 2016 | 1822 | 2016 |
| Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. Z Chen, J Hagler, VJ Palombella, F Melandri, D Scherer, D Ballard, ... Genes & development 9 (13), 1586-1597, 1995 | 1764 | 1995 |
| Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation S Liu, X Cai, J Wu, Q Cong, X Chen, T Li, F Du, J Ren, YT Wu, NV Grishin, ... Science 347 (6227), aaa2630, 2015 | 1716 | 2015 |
| Ubiquitin signalling in the NF-κB pathway ZJ Chen Nature cell biology 7 (8), 758-765, 2005 | 1683 | 2005 |
| RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway YH Chiu, JB MacMillan, ZJ Chen Cell 138 (3), 576-591, 2009 | 1439 | 2009 |
| MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response F Hou, L Sun, H Zheng, B Skaug, QX Jiang, ZJ Chen Cell 146 (3), 448-461, 2011 | 1376 | 2011 |
| Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity ZJ Chen, L Parent, T Maniatis Cell 84 (6), 853-862, 1996 | 1326 | 1996 |
| STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway Y Tanaka, ZJ Chen Science signaling 5 (214), ra20-ra20, 2012 | 1280 | 2012 |
| Innate immune sensing and signaling of cytosolic nucleic acids J Wu, ZJ Chen Annual review of immunology 32 (1), 461-488, 2014 | 1258 | 2014 |
| Activation of IKK by TNFα requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO CK Ea, L Deng, ZP Xia, G Pineda, ZJ Chen Molecular cell 22 (2), 245-257, 2006 | 1248 | 2006 |
| Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects XD Li, J Wu, D Gao, H Wang, L Sun, ZJ Chen Science 341 (6152), 1390-1394, 2013 | 1151 | 2013 |
| Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses D Gao, J Wu, YT Wu, F Du, C Aroh, N Yan, L Sun, ZJ Chen Science 341 (6148), 903-906, 2013 | 1116 | 2013 |
| Nonproteolytic functions of ubiquitin in cell signaling ZJ Chen, LJ Sun Molecular cell 33 (3), 275-286, 2009 | 1116 | 2009 |