| Fit-for-purpose method development and validation for successful biomarker measurement JW Lee, V Devanarayan, YC Barrett, R Weiner, J Allinson, S Fountain, ... Pharmaceutical research 23 (2), 312-328, 2006 | 893 | 2006 |
| Thrombin responses in human endothelial cells contributions from receptors other than PAR1 include the transactivation of PAR2 by thrombin-cleaved PAR1 PJ O'Brien, N Prevost, M Molino, MK Hollinger, MJ Woolkalis, DS Woulfe, ... Journal of Biological Chemistry 275 (18), 13502-13509, 2000 | 375 | 2000 |
| Toward ‘omic scale metabolite profiling: a dual separation–mass spectrometry approach for coverage of lipid and central carbon metabolism J Ivanisevic, ZJ Zhu, L Plate, R Tautenhahn, S Chen, PJ O’Brien, ... Analytical chemistry 85 (14), 6876-6884, 2013 | 327 | 2013 |
| The novel apolipoprotein A5 is present in human serum, is associated with VLDL, HDL, and chylomicrons, and circulates at very low concentrations compared with other apolipoproteins PJ O’Brien, WE Alborn, JH Sloan, M Ulmer, A Boodhoo, MD Knierman, ... Clinical chemistry 51 (2), 351-359, 2005 | 312 | 2005 |
| Protease activated receptors: theme and variations. PJ O'Brien, M Molino, M Kahn, LF Brass Oncogene 20 (13), 1570-1581, 2001 | 293 | 2001 |
| Altered G Protein‐Coupling Functions of RNA Editing Isoform and Splicing Variant Serotonin2C Receptors Q Wang, PJ O'Brien, CX Chen, DSC Cho, JM Murray, K Nishikura Journal of neurochemistry 74 (3), 1290-1300, 2000 | 262 | 2000 |
| Loss of signaling through the G protein, Gz, results in abnormal platelet activation and altered responses to psychoactive drugs J Yang, J Wu, MA Kowalska, A Dalvi, N Prevost, PJ O'Brien, D Manning, ... Proceedings of the National Academy of Sciences 97 (18), 9984-9989, 2000 | 239 | 2000 |
| Gene induction by coagulation factor Xa is mediated by activation of protease-activated receptor 1 M Riewald, VV Kravchenko, RJ Petrovan, PJ O'Brien, LF Brass, ... Blood 97 (10), 3109-3116, 2001 | 229 | 2001 |
| Method validation and measurement of biomarkers in nonclinical and clinical samples in drug development: a conference report JW Lee, RS Weiner, JM Sailstad, RR Bowsher, DW Knuth, PJ O’Brien, ... Pharmaceutical research 22 (4), 499-511, 2005 | 208 | 2005 |
| Evaluation of the substrate specificity of human mast cell tryptase βI and demonstration of its importance in bacterial infections of the lung C Huang, GT De Sanctis, PJ O'Brien, JP Mizgerd, DS Friend, JM Drazen, ... Journal of Biological Chemistry 276 (28), 26276-26284, 2001 | 188 | 2001 |
| Measurement of insulin-like growth factor-II in physiological fluids and tissues. I. An improved extraction procedure and radioimmunoassay for human and rat fluids RR Bowsher, WEIHUA LEE, JM APATHY, PJ O’BRIEN, AL FERGUSON, ... Endocrinology 128 (2), 805-814, 1991 | 147 | 1991 |
| Targeting of HIV-and SIV-infected cells by CD4-chemokine receptor pseudotypes MJ Endres, S Jaffer, B Haggarty, JD Turner, BJ Doranz, PJ O'Brien, ... Science 278 (5342), 1462-1464, 1997 | 96 | 1997 |
| The development of a fully-integrated immune response model (FIRM) simulator of the immune response through integration of multiple subset models BO Palsson, EL Bradshaw-Pierce, K Jooss, ME Spilker, M Zager, P Vicini, ... BMC systems biology 7 (1), 95, 2013 | 82 | 2013 |
| [18F] FLT–PET Imaging Does Not Always “Light Up” Proliferating Tumor Cells CC Zhang, Z Yan, W Li, K Kuszpit, CL Painter, Q Zhang, PB Lappin, ... Clinical Cancer Research 18 (5), 1303-1312, 2012 | 79* | 2012 |
| Neutrophil proteases can inactivate human PAR3 and abolish the co-receptor function of PAR3 on murine platelets A Cumashi, H Ansuini, N Celli, A De Blasi, PJ O Brien, LF Brass, M Molino THROMBOSIS AND HAEMOSTASIS-STUTTGART- 85 (3), 533-538, 2001 | 64 | 2001 |
| Genes that can be mutated to unmask hidden antigenic determinants in the cuticle of the nematode Caenorhabditis elegans. SM Politz, M Philipp, M Estevez, PJ O'Brien, KJ Chin Proceedings of the National Academy of Sciences 87 (8), 2901-2905, 1990 | 62 | 1990 |
| Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids ME Kurczy, ZJ Zhu, J Ivanisevic, AM Schuyler, K Lalwani, AF Santidrian, ... Nature communications 6, 5998, 2015 | 55 | 2015 |
| Factor XIa–specific IgG and a reversal agent to probe factor XI function in thrombosis and hemostasis T David, YC Kim, LK Ely, I Rondon, H Gao, P O’Brien, MW Bolt, AJ Coyle, ... Science Translational Medicine 8 (353), 353ra112-353ra112, 2016 | 54 | 2016 |
| Monitoring metabolic responses to chemotherapy in single cells and tumors using nanostructure-initiator mass spectrometry (NIMS) imaging PJ O’Brien, M Lee, ME Spilker, CC Zhang, Z Yan, TC Nichols, W Li, ... Cancer & Metabolism 1 (1), 1-14, 2013 | 53 | 2013 |
| Thrombin receptors and protease-activated receptor-2 in human placentation: receptor activation mediates extravillous trophoblast invasion in vitro PJ O'Brien, H Koi, S Parry, LF Brass, JF Strauss III, LP Wang, ... The American journal of pathology 163 (4), 1245-1254, 2003 | 47 | 2003 |
Gary SiuzdakProfessor and Director, Center for Metabolomics, The Scripps Research Instituteایمیل تأیید شده در scripps.edu