دنبال کردن
Saul H. Rosenberg
Saul H. Rosenberg
ایمیل تأیید شده در abbvie.com
عنوان
نقل شده توسط
نقل شده توسط
سال
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
T Oltersdorf, SW Elmore, AR Shoemaker, RC Armstrong, DJ Augeri, ...
Nature 435 (7042), 677, 2005
41642005
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets
AJ Souers, JD Leverson, ER Boghaert, SL Ackler, ND Catron, J Chen, ...
Nature medicine 19 (2), 202, 2013
33102013
ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor
C Tse, AR Shoemaker, J Adickes, MG Anderson, J Chen, S Jin, ...
Cancer research 68 (9), 3421-3428, 2008
23222008
Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour …
WH Wilson, OA O'Connor, MS Czuczman, AS LaCasce, JF Gerecitano, ...
The lancet oncology 11 (12), 1149-1159, 2010
9452010
ABT-888, an orally active poly (ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models
CK Donawho, Y Luo, Y Luo, TD Penning, JL Bauch, JJ Bouska, ...
Clinical cancer research 13 (9), 2728-2737, 2007
9292007
The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536, 2015
8952015
Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours
LM Lasko, CG Jakob, RP Edalji, W Qiu, D Montgomery, EL Digiammarino, ...
Nature 550 (7674), 128, 2017
6922017
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy
JD Leverson, DC Phillips, MJ Mitten, ER Boghaert, D Diaz, SK Tahir, ...
Science translational medicine 7 (279), 279ra40-279ra40, 2015
5852015
Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure− activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation
L Wang, KW Woods, Q Li, KJ Barr, RW McCroskey, SM Hannick, L Gherke, ...
Journal of medicinal chemistry 45 (8), 1697-1711, 2002
5792002
Bcl-2 family proteins are essential for platelet survival
H Zhang, PM Nimmer, SK Tahir, J Chen, RM Fryer, KR Hahn, LA Iciek, ...
Cell death and differentiation 14 (5), 943, 2007
5232007
Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents
Z Xiao, Z Chen, AH Gunasekera, TJ Sowin, SH Rosenberg, S Fesik, ...
Journal of Biological Chemistry 278 (24), 21767-21773, 2003
5172003
Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer
TK Oost, C Sun, RC Armstrong, AS Al-Assaad, SF Betz, TL Deckwerth, ...
Journal of medicinal chemistry 47 (18), 4417-4426, 2004
5142004
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)
JD Leverson, H Zhang, J Chen, SK Tahir, DC Phillips, J Xue, P Nimmer, ...
Cell death & disease 6 (1), e1590, 2015
5072015
Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway
X Jiang, HE Kim, H Shu, Y Zhao, H Zhang, J Kofron, J Donnelly, D Burns, ...
Science 299 (5604), 223-226, 2003
4972003
Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins
CM Park, M Bruncko, J Adickes, J Bauch, H Ding, A Kunzer, KC Marsh, ...
Journal of medicinal chemistry 51 (21), 6902-6915, 2008
4162008
Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL
M Bruncko, TK Oost, BA Belli, H Ding, MK Joseph, A Kunzer, D Martineau, ...
Journal of medicinal chemistry 50 (4), 641-662, 2007
4132007
Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-xL from NMR and Parallel Synthesis
AM Petros, J Dinges, DJ Augeri, SA Baumeister, DA Betebenner, ...
Journal of medicinal chemistry 49 (2), 656-663, 2006
4102006
Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737
SK Tahir, X Yang, MG Anderson, SE Morgan-Lappe, AV Sarthy, J Chen, ...
Cancer research 67 (3), 1176-1183, 2007
3722007
Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity
ZF Tao, L Hasvold, L Wang, X Wang, AM Petros, CH Park, ER Boghaert, ...
ACS medicinal chemistry letters 5 (10), 1088-1093, 2014
3352014
Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth
J Chen, W Wu, SK Tahir, PE Kroeger, SH Rosenberg, LM Cowsert, ...
Neoplasia 2 (3), 235-241, 2000
3332000
سیستم در حال حاضر قادر به انجام عملکرد نیست. بعداً دوباره امتحان کنید.
مقاله‌ها 1–20