An inhibitor of Bcl-2 family proteins induces regression of solid tumours T Oltersdorf, SW Elmore, AR Shoemaker, RC Armstrong, DJ Augeri, ... Nature 435 (7042), 677, 2005 | 4164 | 2005 |
ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets AJ Souers, JD Leverson, ER Boghaert, SL Ackler, ND Catron, J Chen, ... Nature medicine 19 (2), 202, 2013 | 3310 | 2013 |
ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor C Tse, AR Shoemaker, J Adickes, MG Anderson, J Chen, S Jin, ... Cancer research 68 (9), 3421-3428, 2008 | 2322 | 2008 |
Navitoclax, a targeted high-affinity inhibitor of BCL-2, in lymphoid malignancies: a phase 1 dose-escalation study of safety, pharmacokinetics, pharmacodynamics, and antitumour … WH Wilson, OA O'Connor, MS Czuczman, AS LaCasce, JF Gerecitano, ... The lancet oncology 11 (12), 1149-1159, 2010 | 945 | 2010 |
ABT-888, an orally active poly (ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models CK Donawho, Y Luo, Y Luo, TD Penning, JL Bauch, JJ Bouska, ... Clinical cancer research 13 (9), 2728-2737, 2007 | 929 | 2007 |
The promise and peril of chemical probes CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ... Nature chemical biology 11 (8), 536, 2015 | 895 | 2015 |
Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours LM Lasko, CG Jakob, RP Edalji, W Qiu, D Montgomery, EL Digiammarino, ... Nature 550 (7674), 128, 2017 | 692 | 2017 |
Exploiting selective BCL-2 family inhibitors to dissect cell survival dependencies and define improved strategies for cancer therapy JD Leverson, DC Phillips, MJ Mitten, ER Boghaert, D Diaz, SK Tahir, ... Science translational medicine 7 (279), 279ra40-279ra40, 2015 | 585 | 2015 |
Potent, orally active heterocycle-based combretastatin A-4 analogues: synthesis, structure− activity relationship, pharmacokinetics, and in vivo antitumor activity evaluation L Wang, KW Woods, Q Li, KJ Barr, RW McCroskey, SM Hannick, L Gherke, ... Journal of medicinal chemistry 45 (8), 1697-1711, 2002 | 579 | 2002 |
Bcl-2 family proteins are essential for platelet survival H Zhang, PM Nimmer, SK Tahir, J Chen, RM Fryer, KR Hahn, LA Iciek, ... Cell death and differentiation 14 (5), 943, 2007 | 523 | 2007 |
Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents Z Xiao, Z Chen, AH Gunasekera, TJ Sowin, SH Rosenberg, S Fesik, ... Journal of Biological Chemistry 278 (24), 21767-21773, 2003 | 517 | 2003 |
Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer TK Oost, C Sun, RC Armstrong, AS Al-Assaad, SF Betz, TL Deckwerth, ... Journal of medicinal chemistry 47 (18), 4417-4426, 2004 | 514 | 2004 |
Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax) JD Leverson, H Zhang, J Chen, SK Tahir, DC Phillips, J Xue, P Nimmer, ... Cell death & disease 6 (1), e1590, 2015 | 507 | 2015 |
Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway X Jiang, HE Kim, H Shu, Y Zhao, H Zhang, J Kofron, J Donnelly, D Burns, ... Science 299 (5604), 223-226, 2003 | 497 | 2003 |
Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins CM Park, M Bruncko, J Adickes, J Bauch, H Ding, A Kunzer, KC Marsh, ... Journal of medicinal chemistry 51 (21), 6902-6915, 2008 | 416 | 2008 |
Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL M Bruncko, TK Oost, BA Belli, H Ding, MK Joseph, A Kunzer, D Martineau, ... Journal of medicinal chemistry 50 (4), 641-662, 2007 | 413 | 2007 |
Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-xL from NMR and Parallel Synthesis AM Petros, J Dinges, DJ Augeri, SA Baumeister, DA Betebenner, ... Journal of medicinal chemistry 49 (2), 656-663, 2006 | 410 | 2006 |
Influence of Bcl-2 family members on the cellular response of small-cell lung cancer cell lines to ABT-737 SK Tahir, X Yang, MG Anderson, SE Morgan-Lappe, AV Sarthy, J Chen, ... Cancer research 67 (3), 1176-1183, 2007 | 372 | 2007 |
Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity ZF Tao, L Hasvold, L Wang, X Wang, AM Petros, CH Park, ER Boghaert, ... ACS medicinal chemistry letters 5 (10), 1088-1093, 2014 | 335 | 2014 |
Down-regulation of survivin by antisense oligonucleotides increases apoptosis, inhibits cytokinesis and anchorage-independent growth J Chen, W Wu, SK Tahir, PE Kroeger, SH Rosenberg, LM Cowsert, ... Neoplasia 2 (3), 235-241, 2000 | 333 | 2000 |