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Geoff Horsman
Geoff Horsman
Associate Professor of Chemistry, Wilfrid Laurier University
Dirección de correo verificada de wlu.ca
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Phosphonate biochemistry
GP Horsman, DL Zechel
Chemical reviews 117 (8), 5704-5783, 2017
5002017
Focusing mutations into the P. fluorescens esterase binding site increases enantioselectivity more effectively than distant mutations
S Park, KL Morley, GP Horsman, M Holmquist, K Hult, RJ Kazlauskas
Chemistry & biology 12 (1), 45-54, 2005
1692005
Mutations in Distant Residues Moderately Increase the Enantioselectivity of Pseudomonas fluorescens Esterase towards Methyl 3Bromo‐2‐methylpropanoate and …
GP Horsman, AMF Liu, E Henke, UT Bornscheuer, RJ Kazlauskas
Chemistry–A European Journal 9 (9), 1933-1939, 2003
1512003
Resistance to acetolactate synthase inhibitors and quinclorac in a biotype of false cleavers (Galium spurium)
LM Hall, KM Stromme, GP Horsman, MD Devine
Weed Science 46 (4), 390-396, 1998
1341998
Characterization of a carbon-carbon hydrolase from Mycobacterium tuberculosis involved in cholesterol metabolism
NA Lack, KC Yam, ED Lowe, GP Horsman, RL Owen, E Sim, LD Eltis
Journal of Biological Chemistry 285 (1), 434-443, 2010
1192010
Mapping the substrate selectivity of new hydrolases using colorimetric screening: lipases from Bacillus thermocatenulatus and Ophiostoma piliferum, esterases from Pseudomonas …
AMF Liu, NA Somers, RJ Kazlauskas, TS Brush, F Zocher, ...
Tetrahedron: Asymmetry 12 (4), 545-556, 2001
1052001
Genome mining unveils widespread natural product biosynthetic capacity in human oral microbe Streptococcus mutans
L Liu, T Hao, Z Xie, GP Horsman, Y Chen
Scientific Reports 6 (1), 37479, 2016
672016
Polyketide synthase chemistry does not direct biosynthetic divergence between 9-and 10-membered enediynes
GP Horsman, Y Chen, JS Thorson, B Shen
Proceedings of the National Academy of Sciences 107 (25), 11331-11335, 2010
652010
Phloem Transport of d,l-Glufosinate and Acetyl-l-Glufosinate in Glufosinate-Resistant and -Susceptible Brassica napus
JN Beriault, GP Horsman, MD Devine
Plant Physiology 121 (2), 619-628, 1999
621999
An anaerobic bacterium host system for heterologous expression of natural product biosynthetic gene clusters
T Hao, Z Xie, M Wang, L Liu, Y Zhang, W Wang, Z Zhang, X Zhao, P Li, ...
Nature Communications 10 (1), 3665, 2019
612019
Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids
Y Yan, J Yang, Z Yu, M Yu, YT Ma, L Wang, C Su, J Luo, GP Horsman, ...
Nature Communications 7 (1), 13083, 2016
602016
Kinetic and Structural Insight into the Mechanism of BphD, a C− C Bond Hydrolase from the Biphenyl Degradation Pathway
GP Horsman, J Ke, S Dai, SYK Seah, JT Bolin, LD Eltis
Biochemistry 45 (37), 11071-11086, 2006
592006
Tropolone Ring Construction in the Biosynthesis of Rubrolone B, a Cationic Tropolone Alkaloid from Endophytic Streptomyces
Y Yan, YT Ma, J Yang, GP Horsman, D Luo, X Ji, SX Huang
Organic letters 18 (6), 1254-1257, 2016
582016
Improvement of the Enediyne Antitumor Antibiotic C-1027 Production by Manipulating Its Biosynthetic Pathway Regulation in Streptomyces globisporus
Y Chen, M Yin, GP Horsman, B Shen
Journal of natural products 74 (3), 420-424, 2011
552011
A Glutathione S-Transferase Catalyzes the Dehalogenation of Inhibitory Metabolites of Polychlorinated Biphenyls
PD Fortin, GP Horsman, HM Yang, LD Eltis
Journal of bacteriology 188 (12), 4424-4430, 2006
532006
Characterization of a C—C Bond Hydrolase from Sphingomonas wittichii RW1 with Novel Specificities towards Polychlorinated Biphenyl Metabolites
SYK Seah, J Ke, G Denis, GP Horsman, PD Fortin, CJ Whiting, LD Eltis
Journal of bacteriology 189 (11), 4038-4045, 2007
512007
Spectroscopic studies of the anaerobic enzyme− substrate complex of catechol 1, 2-dioxygenase
GP Horsman, A Jirasek, FH Vaillancourt, CJ Barbosa, AA Jarzecki, C Xu, ...
Journal of the American Chemical Society 127 (48), 16882-16891, 2005
512005
Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of …
JR Lohman, SX Huang, GP Horsman, PE Dilfer, T Huang, Y Chen, ...
Molecular BioSystems 9 (3), 478-491, 2013
472013
The tautomeric half-reaction of BphD, a CC bond hydrolase: kinetic and structural evidence supporting a key role for histidine 265 of the catalytic triad
GP Horsman, S Bhowmik, SYK Seah, P Kumar, JT Bolin, LD Eltis
Journal of Biological Chemistry 282 (27), 19894-19904, 2007
452007
Manipulation of pathway regulation in Streptomyces globisporus for overproduction of the enediyne antitumor antibiotic C-1027
Y Chen, M Yin, GP Horsman, S Huang, B Shen
The Journal of antibiotics 63 (8), 482-485, 2010
402010
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