| Getting to the core of protein pharmaceuticals–comprehensive structure analysis by mass spectrometry U Leurs, UH Mistarz, KD Rand European Journal of Pharmaceutics and Biopharmaceutics 93, 95-109, 2015 | 74 | 2015 |
| Interlaboratory comparison of hydrogen–deuterium exchange mass spectrometry measurements of the Fab fragment of NISTmAb JW Hudgens, ES Gallagher, I Karageorgos, KW Anderson, JJ Filliben, ... Analytical chemistry 91 (11), 7336-7345, 2019 | 55 | 2019 |
| Enhanced enzymatic stability and antitumor activity of daunorubicin-GnRH-III bioconjugates modified in position 4 M Manea, U Leurs, E Orbán, Z Baranyai, P Öhlschläger, A Marquardt, ... Bioconjugate chemistry 22 (7), 1320-1329, 2011 | 44 | 2011 |
| Efficient synthesis of an (aminooxy) acetylated‐somatostatin derivative using (aminooxy) acetic acid as a ‘carbonyl capture’reagent G Mezö, I Szabó, I Kertesz, R Hegedüs, E Orbán, U Leurs, S Bösze, ... Journal of Peptide Science 17 (1), 39-46, 2011 | 39 | 2011 |
| Substrate-and cofactor-independent inhibition of histone demethylase KDM4C U Leurs, B Lohse, KD Rand, S Ming, ES Riise, PA Cole, JL Kristensen, ... ACS chemical biology 9 (9), 2131-2138, 2014 | 37 | 2014 |
| GnRH-III based multifunctional drug delivery systems containing daunorubicin and methotrexate U Leurs, E Lajkó, G Mező, E Orbán, P Öhlschläger, A Marquardt, ... European journal of medicinal chemistry 52, 173-183, 2012 | 37 | 2012 |
| Quantitative proteome comparison of human hearts with those of model organisms N Linscheid, A Santos, PC Poulsen, RW Mills, K Calloe, U Leurs, JZ Ye, ... PLoS biology 19 (4), e3001144, 2021 | 36 | 2021 |
| GHB analogs confer neuroprotection through specific interaction with the CaMKIIα hub domain U Leurs, AB Klein, ED McSpadden, N Griem-Krey, SMØ Solbak, J Houlton, ... Proceedings of the National Academy of Sciences 118 (31), e2108079118, 2021 | 35 | 2021 |
| Posttranslational modifications of the histone 3 tail and their impact on the activity of histone lysine demethylases in vitro B Lohse, C Helgstrand, JBL Kristensen, U Leurs, PAC Cloos, ... PLoS One 8 (7), e67653, 2013 | 31 | 2013 |
| Inhibitor scaffold for the histone lysine demethylase KDM4C (JMJD2C) U Leurs, RP Clausen, JL Kristensen, B Lohse Bioorganic & medicinal chemistry letters 22 (18), 5811-5813, 2012 | 26 | 2012 |
| Design, synthesis, in vitro stability and cytostatic effect of multifunctional anticancer drug‐bioconjugates containing GnRH‐III as a targeting moiety U Leurs, G Mező, E Orbán, P Öhlschläger, A Marquardt, M Manea Peptide Science 98 (1), 1-10, 2012 | 26 | 2012 |
| Dissecting the binding mode of low affinity phage display peptide ligands to protein targets by hydrogen/deuterium exchange coupled to mass spectrometry U Leurs, B Lohse, S Ming, PA Cole, RP Clausen, JL Kristensen, KD Rand Analytical chemistry 86 (23), 11734-11741, 2014 | 23 | 2014 |
| The impact of the ‘Austrian’mutation of the amyloid precursor protein transmembrane helix is communicated to the hinge region W Stelzer, C Scharnagl, U Leurs, KD Rand, D Langosch ChemistrySelect 1 (15), 4408-4412, 2016 | 15 | 2016 |
| Silencing of spontaneous activity at α4β1/3δ GABAA receptors in hippocampal granule cells reveals different ligand pharmacology NO Dalby, CB Falk‐Petersen, U Leurs, P Scholze, J Krall, B Frølund, ... British Journal of Pharmacology 177 (17), 3975-3990, 2020 | 13 | 2020 |
| Improved prediction of HLA antigen presentation hotspots: Applications for immunogenicity risk assessment of therapeutic proteins AS Attermann, C Barra, B Reynisson, HS Schultz, U Leurs, K Lamberth, ... Immunology 162 (2), 208-219, 2021 | 12 | 2021 |
| Quantitative proteomics characterization of acutely isolated primary adult rat cardiomyocytes and fibroblasts PC Poulsen, M Schrölkamp, N Bagwan, U Leurs, ESA Humphries, ... Journal of Molecular and Cellular Cardiology 143, 63-70, 2020 | 10 | 2020 |
| Mapping the interactions of selective biochemical probes of antibody conformation by hydrogen–deuterium exchange mass spectrometry U Leurs, H Beck, L Bonnington, I Lindner, E Pol, K Rand ChemBioChem 18 (11), 1016-1021, 2017 | 9 | 2017 |
| Charting the interactome of PDE3A in human cells using an IBMX based chemical proteomics approach E Corradini, G Klaasse, U Leurs, AJR Heck, NI Martin, A Scholten Molecular Biosystems 11 (10), 2786-2797, 2015 | 9 | 2015 |
| Applications of mass spectrometry in drug development science U Leurs, UH Mistarz, KD Rand Analytical techniques in the pharmaceutical sciences, 253-289, 2016 | 7 | 2016 |
| Exploring the NCS-382 Scaffold for CaMKIIα Modulation: Synthesis, Biochemical Pharmacology, and Biophysical Characterization of Ph-HTBA as a Novel High-Affinity Brain-Penetrant … Y Tian, MA Shehata, SJ Gauger, C Veronesi, L Hamborg, L Thiesen, ... Journal of Medicinal Chemistry 65 (22), 15066-15084, 2022 | 4 | 2022 |
