A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders E Wambre, V Bajzik, JH DeLong, K O’Brien, QA Nguyen, C Speake, ... Science translational medicine 9 (401), eaam9171, 2017 | 375 | 2017 |
Systems scale interactive exploration reveals quantitative and qualitative differences in response to influenza and pneumococcal vaccines G Obermoser, S Presnell, K Domico, H Xu, Y Wang, E Anguiano, ... Immunity 38 (4), 831-844, 2013 | 314 | 2013 |
Copy number loss of the interferon gene cluster in melanomas is linked to reduced T cell infiltrate and poor patient prognosis PS Linsley, C Speake, E Whalen, D Chaussabel PloS one 9 (10), e109760, 2014 | 213 | 2014 |
Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression AE Wiedeman, VS Muir, MG Rosasco, HA DeBerg, S Presnell, B Haas, ... The Journal of clinical investigation 130 (1), 480-490, 2020 | 151 | 2020 |
ISPAD Clinical Practice Consensus Guidelines 2022: Stages of type 1 diabetes in children and adolescents. REJ Besser, KJ Bell, JJ Couper, AG Ziegler, DK Wherrett, M Knip, ... Pediatric diabetes 23 (8), 2022 | 110 | 2022 |
Proinsulin secretion is a persistent feature of type 1 diabetes EK Sims, HT Bahnson, J Nyalwidhe, L Haataja, AK Davis, C Speake, ... Diabetes care 42 (2), 258-264, 2019 | 99 | 2019 |
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine DK Tobias, J Merino, A Ahmad, C Aiken, JL Benham, D Bodhini, AL Clark, ... Nature medicine 29 (10), 2438-2457, 2023 | 96 | 2023 |
Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes HA Abdelsamed, CC Zebley, H Nguyen, RL Rutishauser, Y Fan, ... Nature immunology 21 (5), 578-587, 2020 | 93 | 2020 |
Modular transcriptional repertoire analyses identify a blood neutrophil signature as a candidate biomarker for lupus nephritis N Jourde-Chiche, E Whalen, B Gondouin, C Speake, V Gersuk, B Dussol, ... Rheumatology 56 (3), 477-487, 2017 | 77 | 2017 |
Single-cell RNA sequencing reveals expanded clones of islet antigen-reactive CD4+ T cells in peripheral blood of subjects with type 1 diabetes K Cerosaletti, F Barahmand-pour-Whitman, J Yang, HA DeBerg, ... The Journal of Immunology 199 (1), 323-335, 2017 | 70 | 2017 |
Standardizing T-cell biomarkers in type 1 diabetes: challenges and recent advances S Ahmed, K Cerosaletti, E James, SA Long, S Mannering, C Speake, ... Diabetes 68 (7), 1366-1379, 2019 | 65 | 2019 |
Advances in type 1 diabetes prediction using islet autoantibodies: beyond a simple count M So, C Speake, AK Steck, M Lundgren, PG Colman, JP Palmer, ... Endocrine reviews 42 (5), 584-604, 2021 | 56 | 2021 |
Endomembrane targeting of human OAS1 p46 augments antiviral activity FW Soveg, J Schwerk, NS Gokhale, K Cerosaletti, JR Smith, ... Elife 10, e71047, 2021 | 56 | 2021 |
An interactive web application for the dissemination of human systems immunology data C Speake, S Presnell, K Domico, B Zeitner, A Bjork, D Anderson, ... Journal of translational medicine 13, 1-10, 2015 | 56 | 2015 |
Strength in numbers: opportunities for enhancing the development of effective treatments for type 1 diabetes—the TrialNet experience CJ Greenbaum, C Speake, J Krischer, J Buckner, PA Gottlieb, DA Schatz, ... Diabetes 67 (7), 1216-1225, 2018 | 49 | 2018 |
NETosis-associated serum biomarkers are reduced in type 1 diabetes in association with neutrophil count J Qin, S Fu, C Speake, CJ Greenbaum, JM Odegard Clinical & Experimental Immunology 184 (3), 318-322, 2016 | 48 | 2016 |
B lymphocyte alterations accompany abatacept resistance in new-onset type 1 diabetes PS Linsley, CJ Greenbaum, C Speake, SA Long, MJ Dufort JCI insight 4 (4), 2019 | 47 | 2019 |
Abnormalities in proinsulin processing in islets from individuals with longstanding T1D EK Sims, F Syed, J Nyalwidhe, HT Bahnson, L Haataja, C Speake, ... Translational Research 213, 90-99, 2019 | 46 | 2019 |
Low HERV-K (C4) copy number is associated with type 1 diabetes MJ Mason, C Speake, VH Gersuk, QA Nguyen, KK O’Brien, JM Odegard, ... Diabetes 63 (5), 1789-1795, 2014 | 46 | 2014 |
Hybrid insulin peptides are recognized by human T cells in the context of DRB1* 04: 01 D Arribas-Layton, P Guyer, T Delong, M Dang, IT Chow, C Speake, ... Diabetes 69 (7), 1492-1502, 2020 | 45 | 2020 |