| Dioxygen activation and methane hydroxylation by soluble methane monooxygenase: a tale of two irons and three proteins M Merkx, DA Kopp, MH Sazinsky, JL Blazyk, J Müller, SJ Lippard Angewandte Chemie International Edition 40 (15), 2782-2807, 2001 | 870 | 2001 |
| Genetically encoded FRET sensors to monitor intracellular Zn2+ homeostasis JL Vinkenborg, TJ Nicolson, EA Bellomo, MS Koay, GA Rutter, M Merkx Nature methods 6 (10), 737-740, 2009 | 486 | 2009 |
| Quantitative understanding of the energy transfer between fluorescent proteins connected via flexible peptide linkers TH Evers, EMWM van Dongen, AC Faesen, EW Meijer, M Merkx Biochemistry 45 (44), 13183-13192, 2006 | 256 | 2006 |
| Human copper transporter 2 is localized in late endosomes and lysosomes and facilitates cellular copper uptake PVE Van den Berghe, DE Folmer, HEM Malingré, E Van Beurden, ... Biochemical journal 407 (1), 49-59, 2007 | 245 | 2007 |
| Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation J Wang, C Luo, C Shan, Q You, J Lu, S Elf, Y Zhou, Y Wen, JL Vinkenborg, ... Nature chemistry 7 (12), 968-979, 2015 | 244 | 2015 |
| Tuning the flexibility of glycine-serine linkers to allow rational design of multidomain proteins M Van Rosmalen, M Krom, M Merkx Biochemistry 56 (50), 6565-6574, 2017 | 213 | 2017 |
| Fluorescently labeled collagen binding proteins allow specific visualization of collagen in tissues and live cell culture KN Krahn, CVC Bouten, S van Tuijl, MAMJ van Zandvoort, M Merkx Analytical biochemistry 350 (2), 177-185, 2006 | 211 | 2006 |
| Branched KLVFF tetramers strongly potentiate inhibition of β‐Amyloid aggregation SM Chafekar, H Malda, M Merkx, EW Meijer, D Viertl, HA Lashuel, F Baas, ... ChemBioChem 8 (15), 1857-1864, 2007 | 181 | 2007 |
| An optical sensor based on a photonic polymer film to detect calcium in serum M Moirangthem, R Arts, M Merkx, APHJ Schenning Advanced functional materials 26 (8), 1154-1160, 2016 | 145 | 2016 |
| Paper‐based antibody detection devices using bioluminescent BRET‐switching sensor proteins K Tenda, B van Gerven, R Arts, Y Hiruta, M Merkx, D Citterio Angewandte Chemie International Edition 57 (47), 15369-15373, 2018 | 143 | 2018 |
| Detection of antibodies in blood plasma using bioluminescent sensor proteins and a smartphone R Arts, I Den Hartog, SE Zijlema, V Thijssen, SHE Van Der Beelen, ... Analytical chemistry 88 (8), 4525-4532, 2016 | 141 | 2016 |
| Supramolecular control of enzyme activity through cucurbit [8] uril-mediated dimerization. DT Dang, HD Nguyen, M Merkx, L Brunsveld Angewandte Chemie International Edition 52 (10), 2013 | 135 | 2013 |
| Variation of linker length in ratiometric fluorescent sensor proteins allows rational tuning of Zn (II) affinity in the picomolar to femtomolar range EMWM van Dongen, TH Evers, LM Dekkers, EW Meijer, LWJ Klomp, ... Journal of the American Chemical Society 129 (12), 3494-3495, 2007 | 133 | 2007 |
| Engineering genetically encoded FRET sensors L Lindenburg, M Merkx Sensors 14 (7), 11691-11713, 2014 | 131 | 2014 |
| Mitochondrial and ER-Targeted eCALWY Probes Reveal High Levels of Free Zn2+ P Chabosseau, E Tuncay, G Meur, EA Bellomo, A Hessels, S Hughes, ... ACS chemical biology 9 (9), 2111-2120, 2014 | 130 | 2014 |
| Multivalent peptide and protein dendrimers using native chemical ligation I Van Baal, H Malda, SA Synowsky, JLJ van Dongen, TM Hackeng, ... Angewandte Chemie-International Edition 44 (32), 5052-5056, 2005 | 124 | 2005 |
| Ratiometric fluorescent sensor proteins with subnanomolar affinity for Zn (II) based on copper chaperone domains EMWM van Dongen, LM Dekkers, K Spijker, EW Meijer, LWJ Klomp, ... Journal of the American Chemical Society 128 (33), 10754-10762, 2006 | 122 | 2006 |
| High resolution imaging of collagen organisation and synthesis using a versatile collagen specific probe RA Boerboom, KN Krahn, RTA Megens, MAMJ van Zandvoort, M Merkx, ... Journal of structural biology 159 (3), 392-399, 2007 | 119 | 2007 |
| Colorful protein-based fluorescent probes for collagen imaging SJA Aper, ACC van Spreeuwel, MC van Turnhout, AJ van der Linden, ... PloS one 9 (12), e114983, 2014 | 112 | 2014 |
| Enhanced sensitivity of FRET‐based protease sensors by redesign of the GFP dimerization interface JL Vinkenborg, TH Evers, SWA Reulen, EW Meijer, M Merkx ChemBioChem 8 (10), 1119-1121, 2007 | 109 | 2007 |
