| Protocol for application, standardization and validation of the forskolin-induced swelling assay in cystic fibrosis human colon organoids AM Vonk, P van Mourik, AS Ramalho, IAL Silva, M Statia, E Kruisselbrink, ... STAR protocols 1 (1), 100019, 2020 | 106 | 2020 |
| Mutant CFTR Drives TWIST1 mediated epithelial–mesenchymal transition MC Quaresma, I Pankonien, LA Clarke, LS Sousa, IAL Silva, V Railean, ... Cell Death & Disease 11 (10), 920, 2020 | 47 | 2020 |
| MiR-29a is an enhancer of mineral deposition in bone-derived systems VP Roberto, DM Tiago, IAL Silva, ML Cancela Archives of biochemistry and biophysics 564, 173-183, 2014 | 42 | 2014 |
| TMEM16A chloride channel does not drive mucus production FB Simões, MC Quaresma, LA Clarke, IAL Silva, I Pankonien, V Railean, ... Life science alliance 2 (6), 2019 | 41 | 2019 |
| Pharmacological modulation of ion channels for the treatment of cystic fibrosis MC Pinto, IAL Silva, MF Figueira, MD Amaral, M Lopes-Pacheco Journal of Experimental Pharmacology, 693-723, 2021 | 39 | 2021 |
| R560S: A class II CFTR mutation that is not rescued by current modulators NT Awatade, S Ramalho, IAL Silva, V Felício, HM Botelho, E de Poel, ... Journal of Cystic Fibrosis 18 (2), 182-189, 2019 | 37 | 2019 |
| A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic JR Lérias, MC Pinto, HM Botelho, NT Awatade, MC Quaresma, IAL Silva, ... Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1865 (2), 421-431, 2018 | 35 | 2018 |
| The effect of premature termination codon mutations on CFTR mRNA abundance in human nasal epithelium and intestinal organoids: a basis for read‐through … LA Clarke, NT Awatade, VM Felício, IA Silva, M Calucho, L Pereira, ... Human mutation 40 (3), 326-334, 2019 | 33 | 2019 |
| Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia GD Amatngalim, LW Rodenburg, BL Aalbers, HHM Raeven, EM Aarts, ... Life Science Alliance 5 (12), 2022 | 29 | 2022 |
| Personalized medicine based on nasal epithelial cells: comparative studies with rectal biopsies and intestinal organoids IAL Silva, V Railean, A Duarte, MD Amaral Journal of Personalized Medicine 11 (5), 421, 2021 | 25 | 2021 |
| Effect of genetic variants of OPTN in the pathophysiology of Paget's disease of bone IAL Silva, N Conceição, É Gagnon, H Caiado, JP Brown, F Gianfrancesco, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1864 (1), 143-151, 2018 | 25 | 2018 |
| Advances in preclinical in vitro models for the translation of precision medicine for cystic fibrosis IAL Silva, O Laselva, M Lopes-Pacheco Journal of Personalized Medicine 12 (8), 1321, 2022 | 23 | 2022 |
| Synergy in cystic fibrosis therapies: targeting SLC26A9 MC Pinto, MC Quaresma, IAL Silva, V Railean, SS Ramalho, MD Amaral International journal of molecular sciences 22 (23), 13064, 2021 | 20 | 2021 |
| Rare trafficking CFTR mutations involve distinct cellular retention machineries and require different rescuing strategies SS Ramalho, IAL Silva, MD Amaral, CM Farinha International Journal of Molecular Sciences 23 (1), 24, 2021 | 17 | 2021 |
| Characterization of the mechanism of action of RDR01752, a novel corrector of F508del-CFTR M Lopes-Pacheco, IAL Silva, MJ Turner, GW Carlile, E Sondo, ... Biochemical Pharmacology 180, 114133, 2020 | 17 | 2020 |
| Molecular characterization of two paralog genes encoding Gla‐rich protein (Grp) in zebrafish C Fazenda, IAL Silva, ML Cancela, N Conceição Journal of Applied Ichthyology 28 (3), 377-381, 2012 | 17 | 2012 |
| Organoids as a personalized medicine tool for ultra-rare mutations in cystic fibrosis: The case of S955P and 1717-2A> G IAL Silva, T Doušová, S Ramalho, R Centeio, LA Clarke, V Railean, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1866 (11), 165905, 2020 | 14 | 2020 |
| KLF4 Acts as a wt-CFTR Suppressor through an AKT-Mediated Pathway L Sousa, I Pankonien, LA Clarke, I Silva, K Kunzelmann, MD Amaral Cells 9 (7), 1607, 2020 | 14 | 2020 |
| An open-source high-content analysis workflow for CFTR function measurements using the forskolin-induced swelling assay MC Hagemeijer, AM Vonk, NT Awatade, IAL Silva, C Tischer, ... Bioinformatics 36 (24), 5686-5694, 2020 | 13 | 2020 |
| Molecular effect of an OPTN common variant associated to Paget's disease of bone IAL Silva, N Conceição, E Gagnon, JP Brown, ML Cancela, L Michou Plos one 13 (5), e0197543, 2018 | 12 | 2018 |
Margarida AmaralProfessor of Molecular Biology, Faculty of Sciences, University of LisboaDirección de correo verificada de fc.ul.pt
