| Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer M Peifer, L Fernández-Cuesta, ML Sos, J George, D Seidel, LH Kasper, ... Nature genetics 44 (10), 1104-1110, 2012 | 1528 | 2012 |
| Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer J Weiss, ML Sos, D Seidel, M Peifer, T Zander, JM Heuckmann, RT Ullrich, ... Science translational medicine 2 (62), 62ra93-62ra93, 2010 | 1015 | 2010 |
| Mutations in the DDR2 Kinase Gene Identify a Novel Therapeutic Target in Squamous Cell Lung Cancer PS Hammerman, ML Sos, AH Ramos, C Xu, A Dutt, W Zhou, LE Brace, ... Cancer discovery 1 (1), 78-89, 2011 | 593 | 2011 |
| Highly enantioselective synthesis and cellular evaluation of spirooxindoles inspired by natural products AP Antonchick, C Gerding-Reimers, M Catarinella, M Schürmann, H Preut, ... Nature chemistry 2 (9), 735-740, 2010 | 581 | 2010 |
| Small-molecule inhibition of APT1 affects Ras localization and signaling FJ Dekker, O Rocks, N Vartak, S Menninger, C Hedberg, R Balamurugan, ... Nature chemical biology 6 (6), 449-456, 2010 | 423 | 2010 |
| Natural-product-derived fragments for fragment-based ligand discovery B Over, S Wetzel, C Grütter, Y Nakai, S Renner, D Rauh, H Waldmann Nature chemistry 5 (1), 21-28, 2013 | 331 | 2013 |
| Identification of Thiazolidinones Spiro‐Fused to Indolin‐2‐ones as Potent and Selective Inhibitors of the Mycobacterium tuberculosis Protein Tyrosine Phosphatase … VV Vintonyak, K Warburg, H Kruse, S Grimme, K Hübel, D Rauh, ... Angewandte Chemie 34 (122), 6038-6041, 2010 | 328 | 2010 |
| Predicting drug susceptibility of non–small cell lung cancers based on genetic lesions ML Sos, K Michel, T Zander, J Weiss, P Frommolt, M Peifer, D Li, R Ullrich, ... The Journal of clinical investigation 119 (6), 1727-1740, 2009 | 325 | 2009 |
| An unbiased cell morphology–based screen for new, biologically active small molecules M Tanaka, R Bateman, D Rauh, E Vaisberg, S Ramachandani, C Zhang, ... PLoS biology 3 (5), e128, 2005 | 317 | 2005 |
| Identifying genotype-dependent efficacy of single and combined PI3K-and MAPK-pathway inhibition in cancer ML Sos, S Fischer, R Ullrich, M Peifer, JM Heuckmann, M Koker, ... Proceedings of the National Academy of Sciences 106 (43), 18351-18356, 2009 | 300 | 2009 |
| Interactive exploration of chemical space with Scaffold Hunter S Wetzel, K Klein, S Renner, D Rauh, TI Oprea, P Mutzel, H Waldmann Nature chemical biology 5 (8), 581-583, 2009 | 260 | 2009 |
| Chemogenomic profiling provides insights into the limited activity of irreversible EGFR Inhibitors in tumor cells expressing the T790M EGFR resistance mutation ML Sos, HB Rode, S Heynck, M Peifer, F Fischer, S Klüter, VG Pawar, ... Cancer research 70 (3), 868-874, 2010 | 248 | 2010 |
| Structure-guided development of affinity probes for tyrosine kinases using chemical genetics JA Blair, D Rauh, C Kung, CH Yun, QW Fan, H Rode, C Zhang, MJ Eck, ... Nature chemical biology 3 (4), 229-238, 2007 | 245 | 2007 |
| Tumor VEGF: VEGFR2 autocrine feed-forward loop triggers angiogenesis in lung cancer S Chatterjee, LC Heukamp, M Siobal, J Schöttle, C Wieczorek, M Peifer, ... The Journal of clinical investigation 123 (4), 1732-1740, 2013 | 235 | 2013 |
| ALK mutations conferring differential resistance to structurally diverse ALK inhibitors JM Heuckmann, M Hölzel, ML Sos, S Heynck, H Balke-Want, M Koker, ... Clinical Cancer Research 17 (23), 7394-7401, 2011 | 232 | 2011 |
| Strategies for the selective regulation of kinases with allosteric modulators: exploiting exclusive structural features Z Fang, C Grütter, D Rauh ACS chemical biology 8 (1), 58-70, 2013 | 229 | 2013 |
| A framework for identification of actionable cancer genome dependencies in small cell lung cancer ML Sos, F Dietlein, M Peifer, J Schöttle, H Balke-Want, C Müller, M Koker, ... Proceedings of the National Academy of Sciences 109 (42), 17034-17039, 2012 | 204 | 2012 |
| The therapeutic potential of phosphatase inhibitors VV Vintonyak, AP Antonchick, D Rauh, H Waldmann Current opinion in chemical biology 13 (3), 272-283, 2009 | 182 | 2009 |
| Development of a fluorescent-tagged kinase assay system for the detection and characterization of allosteric kinase inhibitors JR Simard, M Getlik, C Grütter, V Pawar, S Wulfert, M Rabiller, D Rauh Journal of the American Chemical Society 131 (37), 13286-13296, 2009 | 177 | 2009 |
| BSK s are partially redundant positive regulators of brassinosteroid signaling in A rabidopsis S Sreeramulu, Y Mostizky, S Sunitha, E Shani, H Nahum, D Salomon, ... The Plant Journal 74 (6), 905-919, 2013 | 174 | 2013 |
