| Precise gene editing preserves hematopoietic stem cell function following transient p53-mediated DNA damage response G Schiroli, A Conti, S Ferrari, L Della Volpe, A Jacob, L Albano, S Beretta, ... Cell stem cell 24 (4), 551-565. e8, 2019 | 283 | 2019 |
| Managing, analysing, and integrating big data in medical bioinformatics: open problems and future perspectives I Merelli, H Pérez-Sánchez, S Gesing, D D’Agostino BioMed research international 2014 (1), 134023, 2014 | 229 | 2014 |
| Efficient gene editing of human long-term hematopoietic stem cells validated by clonal tracking S Ferrari, A Jacob, S Beretta, G Unali, L Albano, V Vavassori, D Cittaro, ... Nature biotechnology 38 (11), 1298-1308, 2020 | 146 | 2020 |
| A multilevel data integration resource for breast cancer study E Mosca, R Alfieri, I Merelli, F Viti, A Calabria, L Milanesi BMC systems biology 4, 1-11, 2010 | 116 | 2010 |
| HIV-1-mediated insertional activation of STAT5B and BACH2 trigger viral reservoir in T regulatory cells D Cesana, FR Santoni de Sio, L Rudilosso, P Gallina, A Calabria, ... Nature communications 8 (1), 498, 2017 | 106 | 2017 |
| StreamFlow: cross-breeding cloud with HPC I Colonnelli, B Cantalupo, I Merelli, M Aldinucci IEEE Transactions on Emerging Topics in Computing, 2020 | 86 | 2020 |
| RSSsite: a reference database and prediction tool for the identification of cryptic Recombination Signal Sequences in human and murine genomes I Merelli, A Guffanti, M Fabbri, A Cocito, L Furia, U Grazini, RJ Bonnal, ... Nucleic acids research 38 (suppl_2), W262-W267, 2010 | 84 | 2010 |
| Genotoxic effects of base and prime editing in human hematopoietic stem cells M Fiumara, S Ferrari, A Omer-Javed, S Beretta, L Albano, D Canarutto, ... Nature biotechnology 42 (6), 877-891, 2024 | 76 | 2024 |
| Grid-Enabled High-Throughput In Silico Screening Against Influenza A Neuraminidase HC Lee, J Salzemann, N Jacq, HY Chen, LY Ho, I Merelli, L Milanesi, ... IEEE transactions on nanobioscience 5 (4), 288-295, 2006 | 74 | 2006 |
| Choice of template delivery mitigates the genotoxic risk and adverse impact of editing in human hematopoietic stem cells S Ferrari, A Jacob, D Cesana, M Laugel, S Beretta, A Varesi, G Unali, ... Cell Stem Cell 29 (10), 1428-1444. e9, 2022 | 73 | 2022 |
| Molecular mechanism of allosteric communication in Hsp70 revealed by molecular dynamics simulations F Chiappori, I Merelli, G Colombo, L Milanesi, G Morra PLoS computational biology 8 (12), e1002844, 2012 | 65 | 2012 |
| DNA damage contributes to neurotoxic inflammation in Aicardi-Goutières syndrome astrocytes AMS Giordano, M Luciani, F Gatto, M Abou Alezz, C Beghè, L Della Volpe, ... Journal of Experimental Medicine 219 (4), e20211121, 2022 | 61 | 2022 |
| DnaK as antibiotic target: hot spot residues analysis for differential inhibition of the bacterial protein in comparison with the human HSP70 F Chiappori, M Fumian, L Milanesi, I Merelli PloS one 10 (4), e0124563, 2015 | 55 | 2015 |
| Virtual screening on large scale grids N Jacq, V Breton, HY Chen, LY Ho, M Hofmann, V Kasam, HC Lee, ... Parallel Computing 33 (4-5), 289-301, 2007 | 54 | 2007 |
| An atomistic view of Hsp70 allosteric crosstalk: from the nucleotide to the substrate binding domain and back F Chiappori, I Merelli, L Milanesi, G Colombo, G Morra Scientific Reports 6 (1), 23474, 2016 | 47 | 2016 |
| Targeted inducible delivery of immunoactivating cytokines reprograms glioblastoma microenvironment and inhibits growth in mouse models F Birocchi, M Cusimano, F Rossari, S Beretta, PMV Rancoita, A Ranghetti, ... Science translational medicine 14 (653), eabl4106, 2022 | 45 | 2022 |
| Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper‐IgM syndrome V Vavassori, E Mercuri, GE Marcovecchio, MC Castiello, G Schiroli, ... EMBO Molecular Medicine 13 (3), e13545, 2021 | 45 | 2021 |
| Combining edge and cloud computing for low-power, cost-effective metagenomics analysis D D’Agostino, L Morganti, E Corni, D Cesini, I Merelli Future Generation Computer Systems 90, 79-85, 2019 | 44 | 2019 |
| Durable and efficient gene silencing in vivo by hit-and-run epigenome editing MA Cappelluti, V Mollica Poeta, S Valsoni, P Quarato, S Merlin, I Merelli, ... Nature 627 (8003), 416-423, 2024 | 43 | 2024 |
| Cloud Infrastructures for In Silico Drug Discovery: Economic and Practical Aspects D D′ Agostino, A Clematis, A Quarati, D Cesini, F Chiappori, L Milanesi, ... BioMed Research International 2013 (1), 138012, 2013 | 42 | 2013 |
