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Reza Farmahin
Reza Farmahin
Scientific Evaluator at Health Canada, Ottawa, ON, Canada
Dirección de correo verificada de canada.ca
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Recommended approaches in the application of toxicogenomics to derive points of departure for chemical risk assessment
R Farmahin, A Williams, B Kuo, NL Chepelev, RS Thomas, ...
Archives of Toxicology, 1-21, 2016
1592016
Amino Acid Sequence of the Ligand-Binding Domain of the Aryl Hydrocarbon Receptor 1 Predicts Sensitivity of Wild Birds to Effects of Dioxin-Like Compounds
R Farmahin, G Manning, D Crump, D Wu, L Mundy, S Jones, ME Hahn, ...
Toxicological Sciences 131 (1), 139-152, 2013
1252013
Sequence and in vitro function of chicken, ring-necked pheasant and Japanese quail AHR1 predict in vivo sensitivity to dioxins
R Farmahin, D Wu, D Crump, JC Hervé, SP Jones, M Hahn, SI Karchner, ...
Environmental Science & Technology 46 (5), 2967-2975, 2012
762012
A luciferase reporter gene assay and aryl hydrocarbon receptor 1 genotype predict the LD< sub> 50</sub> of polychlorinated biphenyls in avian species
GE Manning, R Farmahin, D Crump, SP Jones, J Klein, A Konstantinov, ...
Toxicology and Applied Pharmacology 263 (3), 390-401, 2012
492012
Photolytic degradation products of two highly brominated flame retardants cause cytotoxicity and mRNA expression alterations in chicken embryonic hepatocytes
G Su, RJ Letcher, D Crump, R Farmahin, JP Giesy, SW Kennedy
Environmental science & technology 48 (20), 12039-12046, 2014
432014
Differences in activation of aryl hydrocarbon receptors of white sturgeon relative to lake sturgeon are predicted by identities of key amino acids in the ligand binding domain
JA Doering, R Farmahin, S Wiseman, SC Beitel, SW Kennedy, JP Giesy, ...
Environmental Science & Technology 49 (7), 4681-4689, 2015
412015
Comparing the effects of tetrabromobisphenol‐A, bisphenol A, and their potential replacement alternatives, TBBPA‐bis (2, 3‐dibromopropyl ether) and bisphenol S, on cell …
M Ma, D Crump, R Farmahin, SW Kennedy
Environmental toxicology and chemistry 34 (2), 391-401, 2015
392015
Time-dependent transcriptomic and biochemical responses of 6-formylindolo [3, 2-b] carbazole (FICZ) and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) are explained by AHR …
R Farmahin, D Crump, JM O’Brien, SP Jones, SW Kennedy
Biochemical Pharmacology 115, 134-143, 2016
362016
Hepatic transcriptional dose-response analysis of male and female Fischer rats exposed to hexabromocyclododecane
R Farmahin, AM Gannon, R Gagné, A Rowan-Carroll, B Kuo, A Williams, ...
Food and Chemical Toxicology 133, 110262, 2019
352019
Potency of Polycyclic Aromatic Hydrocarbons (PAHs) for Induction of Ethoxyresorufin-O-deethylase (EROD) Activity in Hepatocyte Cultures from Chicken, Pekin …
JA Head, RW Jeffery, R Farmahin, SW Kennedy
Environmental Science & Technology 49 (6), 3787-3794, 2015
292015
Functionality of Aryl Hydrocarbon Receptors (AhR1 and AhR2) of White Sturgeon (Acipenser transmontanus) and Implications for the Risk Assessment of Dioxin …
JA Doering, R Farmahin, S Wiseman, SW Kennedy, JP Giesy, M Hecker
Environmental science & technology 48 (14), 8219-8226, 2014
292014
Hexabromocyclododecane (HBCD): A case study applying tiered testing for human health risk assessment
AM Gannon, M Moreau, R Farmahin, RS Thomas, TS Barton-Maclaren, ...
Food and Chemical Toxicology 131, 110581, 2019
272019
Sunlight irradiation of highly brominated polyphenyl ethers generates polybenzofuran products that alter dioxin-responsive mRNA expression in chicken hepatocytes
G Su, RJ Letcher, D Crump, R Farmahin, JP Giesy, SW Kennedy
Environmental Science & Technology 50 (5), 2318-2327, 2016
272016
Sensitivity of avian species to the aryl hydrocarbon receptor ligand 6-formylindolo [3, 2-b] carbazole (FICZ)
R Farmahin, D Crump, SW Kennedy
Chemico-Biological Interactions 221, 61-69, 2014
272014
From vision toward best practices: Evaluating in vitro transcriptomic points of departure for application in risk assessment using a uniform workflow
AJF Reardon, R Farmahin, A Williams, MJ Meier, GC Addicks, CL Yauk, ...
Frontiers in Toxicology 5, 1194895, 2023
232023
Relative potencies of aroclor mixtures derived from avian in vitro bioassays: comparisons with calculated toxic equivalents
R Zhang, GE Manning, R Farmahin, D Crump, X Zhang, SW Kennedy
Environmental science & technology 47 (15), 8852-8861, 2013
232013
In vitro dioxin-like potencies of HO-and MeO-PBDEs and inter-species sensitivity variation in birds
R Zhang, J Zhang, X Zhang, J Zhang, G Su, R Farmahin, JP Giesy, H Yu
Ecotoxicology and environmental safety 126, 202-210, 2016
182016
Photolysis of highly brominated flame retardants leads to time-dependent dioxin-responsive mRNA expression in chicken embryonic hepatocytes
G Su, RJ Letcher, R Farmahin, D Crump
Chemosphere 194, 352-359, 2018
172018
In vitro transcriptomic analyses reveal pathway perturbations, estrogenic activities, and potencies of data-poor BPA alternative chemicals
G Matteo, K Leingartner, A Rowan-Carroll, M Meier, A Williams, MA Beal, ...
Toxicological Sciences 191 (2), 266-275, 2023
162023
Cytochrome P4501A induction in primary cultures of embryonic European starling hepatocytes exposed to TCDD, PeCDF and TCDF
R Farmahin, D Crump, SP Jones, LJ Mundy, SW Kennedy
Ecotoxicology 22, 731-739, 2013
162013
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