| Molecular basis of agonism and antagonism in the oestrogen receptor AM Brzozowski, ACW Pike, Z Dauter, RE Hubbard, T Bonn, O Engström, ... Nature 389 (6652), 753-758, 1997 | 4203 | 1997 |
| Hydrogen bonding in globular proteins EN Baker, RE Hubbard Progress in biophysics and molecular biology 44 (2), 97-179, 1984 | 2379 | 1984 |
| Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport SC Hyde, P Emsley, MJ Hartshorn, MM Mimmack, U Gileadi, SR Pearce, ... Nature 346 (6282), 362-365, 1990 | 1567 | 1990 |
| Structure of the ligand‐binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist ACW Pike, AM Brzozowski, RE Hubbard, T Bonn, AG Thorsell, ... The EMBO journal, 1999 | 1306 | 1999 |
| Twenty years on: the impact of fragments on drug discovery DA Erlanson, SW Fesik, RE Hubbard, W Jahnke, H Jhoti Nature reviews Drug discovery 15 (9), 605-619, 2016 | 991 | 2016 |
| The structure of 2Zn pig insulin crystals at 1.5 Å resolution EN Baker, TL Blundell, JF Cutfield, EJ Dodson, GG Dodson, ... Philosophical Transactions of the Royal Society of London. B, Biological …, 1988 | 898 | 1988 |
| Glycosaminoglycans interact selectively with chemokines and modulate receptor binding and cellular responses GSV Kuschert, F Coulin, CA Power, AEI Proudfoot, RE Hubbard, ... Biochemistry 38 (39), 12959-12968, 1999 | 711 | 1999 |
| rDock: a fast, versatile and open source program for docking ligands to proteins and nucleic acids S Ruiz-Carmona, D Alvarez-Garcia, N Foloppe, AB Garmendia-Doval, ... PLoS computational biology 10 (4), e1003571, 2014 | 555 | 2014 |
| NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis SA Eccles, A Massey, FI Raynaud, SY Sharp, G Box, M Valenti, ... Cancer research 68 (8), 2850-2860, 2008 | 553 | 2008 |
| 4, 5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer PA Brough, W Aherne, X Barril, J Borgognoni, K Boxall, JE Cansfield, ... Journal of medicinal chemistry 51 (2), 196-218, 2008 | 520 | 2008 |
| Structural insights into the mode of action of a pure antiestrogen ACW Pike, AM Brzozowski, J Walton, RE Hubbard, AG Thorsell, YL Li, ... Structure 9 (2), 145-153, 2001 | 470 | 2001 |
| Hydrogen bonds in proteins: role and strength RE Hubbard, MK Haider Encyclopedia of life sciences 1, 1-6, 2010 | 459 | 2010 |
| Biophysics in drug discovery: impact, challenges and opportunities JP Renaud, C Chung, UH Danielson, U Egner, M Hennig, RE Hubbard, ... Nature reviews Drug discovery 15 (10), 679-698, 2016 | 429 | 2016 |
| Heat-stable antifreeze protein from grass C Sidebottom, S Buckley, P Pudney, S Twigg, C Jarman, C Holt, J Telford, ... Nature 406 (6793), 256-256, 2000 | 355 | 2000 |
| HOOK: a program for finding novel molecular architectures that satisfy the chemical and steric requirements of a macromolecule binding site MB Eisen, DC Wiley, M Karplus, RE Hubbard Proteins: Structure, Function, and Bioinformatics 19 (3), 199-221, 1994 | 318 | 1994 |
| Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms L Wright, X Barril, B Dymock, L Sheridan, A Surgenor, M Beswick, ... Chemistry & biology 11 (6), 775-785, 2004 | 310 | 2004 |
| Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design BW Dymock, X Barril, PA Brough, JE Cansfield, A Massey, E McDonald, ... Journal of medicinal chemistry 48 (13), 4212-4215, 2005 | 280 | 2005 |
| Towards predictive ligand design with free-energy based computational methods? N Foloppe, R Hubbard Current medicinal chemistry 13 (29), 3583-3608, 2006 | 264 | 2006 |
| Identification of a glycosaminoglycan binding surface on human interleukin-8 GSV Kuschert, AJ Hoogewerf, AEI Proudfoot, C Chung, RM Cooke, ... Biochemistry 37 (32), 11193-11201, 1998 | 236 | 1998 |
| A structural biologist's view of the oestrogen receptor ACW Pike, AM Brzozowski, RE Hubbard The Journal of steroid biochemistry and molecular biology 74 (5), 261-268, 2000 | 225 | 2000 |
