| Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound VJN Bykov, N Issaeva, A Shilov, M Hultcrantz, E Pugacheva, P Chumakov, ... Nature medicine 8 (3), 282-288, 2002 | 1320 | 2002 |
| Targeting mutant p53 for efficient cancer therapy VJN Bykov, SE Eriksson, J Bianchi, KG Wiman Nature Reviews Cancer 18 (2), 89-102, 2018 | 873 | 2018 |
| PRIMA-1 reactivates mutant p53 by covalent binding to the core domain JMR Lambert, P Gorzov, DB Veprintsev, M Söderqvist, D Segerbäck, ... Cancer cell 15 (5), 376-388, 2009 | 666 | 2009 |
| Targeting p53 in vivo: a first-in-human study with p53-targeting compound APR-246 in refractory hematologic malignancies and prostate cancer S Lehmann, VJN Bykov, D Ali, O Andrén, H Cherif, U Tidefelt, B Uggla, ... Journal of clinical oncology 30 (29), 3633-3639, 2012 | 475 | 2012 |
| The p53 tumor suppressor: a master regulator of diverse cellular processes and therapeutic target in cancer M Farnebo, VJN Bykov, KG Wiman Biochemical and biophysical research communications 396 (1), 85-89, 2010 | 353 | 2010 |
| Reactivation of mutant p53 and induction of apoptosis in human tumor cells by maleimide analogs VJN Bykov, N Issaeva, N Zache, A Shilov, M Hultcrantz, J Bergman, ... Journal of Biological Chemistry 280 (34), 30384-30391, 2005 | 302 | 2005 |
| PRIMA-1MET synergizes with cisplatin to induce tumor cell apoptosis VJN Bykov, N Zache, H Stridh, J Westman, J Bergman, G Selivanova, ... Oncogene 24 (21), 3484-3491, 2005 | 288 | 2005 |
| APR-246 reactivates mutant p53 by targeting cysteines 124 and 277 Q Zhang, VJN Bykov, KG Wiman, J Zawacka-Pankau Cell death & disease 9 (5), 439, 2018 | 242 | 2018 |
| Characterization of the p53-rescue drug CP-31398 in vitro and in living cells TM Rippin, VJN Bykov, S Freund, G Selivanova, KG Wiman, AR Fersht Oncogene 21 (14), 2119-2129, 2002 | 241 | 2002 |
| Mutant p53-dependent growth suppression distinguishes PRIMA-1 from known anticancer drugs: a statistical analysis of information in the National Cancer Institute database VJN Bykov, N Issaeva, G Selivanova, KG Wiman Carcinogenesis 23 (12), 2011-2018, 2002 | 226 | 2002 |
| Mutant p53 reactivation by small molecules makes its way to the clinic VJN Bykov, KG Wiman FEBS letters 588 (16), 2622-2627, 2014 | 203 | 2014 |
| APR-246 overcomes resistance to cisplatin and doxorubicin in ovarian cancer cells N Mohell, J Alfredsson, Å Fransson, M Uustalu, S Byström, J Gullbo, ... Cell death & disease 6 (6), e1794-e1794, 2015 | 195 | 2015 |
| APR-246/PRIMA-1MET inhibits thioredoxin reductase 1 and converts the enzyme to a dedicated NADPH oxidase X Peng, MQZ Zhang, F Conserva, G Hosny, G Selivanova, VJN Bykov, ... Cell death & disease 4 (10), e881-e881, 2013 | 185 | 2013 |
| Small molecules that reactivate mutant p53 VJN Bykov, G Selivanova, KG Wiman European Journal of Cancer 39 (13), 1828-1834, 2003 | 155 | 2003 |
| Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis JMR Lambert, A Moshfegh, P Hainaut, KG Wiman, VJN Bykov Oncogene 29 (9), 1329-1338, 2010 | 139 | 2010 |
| Targeting of mutant p53 and the cellular redox balance by APR-246 as a strategy for efficient cancer therapy VJN Bykov, Q Zhang, M Zhang, S Ceder, L Abrahmsen, KG Wiman Frontiers in oncology 6, 21, 2016 | 136 | 2016 |
| Mutant p53 targeting by the low molecular weight compound STIMA-1 N Zache, JMR Lambert, N Rökaeus, J Shen, P Hainaut, J Bergman, ... Molecular oncology 2 (1), 70-80, 2008 | 134 | 2008 |
| In situ repair of cyclobutane pyrimidine dimers and 6–4 photoproducts in human skin exposed to solar simulating radiation VJ Bykov, K Hemminki, JM Sheehan, AR Young Journal of investigative dermatology 112 (3), 326-331, 1999 | 124 | 1999 |
| Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death EH Cheteh, M Augsten, H Rundqvist, J Bianchi, V Sarne, L Egevad, ... Cell death & disease 8 (6), e2848-e2848, 2017 | 105 | 2017 |
| p53 as a hub in cellular redox regulation and therapeutic target in cancer SE Eriksson, S Ceder, VJN Bykov, KG Wiman Journal of molecular cell biology 11 (4), 330-341, 2019 | 104 | 2019 |