Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease JH Kordower, ME Emborg, J Bloch, SY Ma, Y Chu, L Leventhal, J McBride, ... Science 290 (5492), 767-773, 2000 | 1531 | 2000 |
α-Synucleinopathy and selective dopaminergic neuron loss in a rat lentiviral-based model of Parkinson's disease C Lo Bianco, JL Ridet, BL Schneider, N Deglon, P Aebischer Proceedings of the National Academy of Sciences 99 (16), 10813-10818, 2002 | 674 | 2002 |
Intrathecal delivery of CNTF using encapsulated genetically modifiedxenogeneic cells in amyotrophic lateral sclerosis patients P Aebischer, M Schluep, N Déglon, JM Joseph, L Hirt, B Heyd, ... Nature medicine 2 (6), 696-699, 1996 | 566 | 1996 |
Lentiviral-mediated RNA interference T Abbas-Terki, W Blanco-Bose, N Déglon, W Pralong, P Aebischer Human gene therapy 13 (18), 2197-2201, 2002 | 457 | 2002 |
Isolation of multipotent neural precursors residing in the cortex of the adult human brain Y Arsenijevic, JG Villemure, JF Brunet, JJ Bloch, N Déglon, C Kostic, ... Experimental neurology 170 (1), 48-62, 2001 | 432 | 2001 |
In vivo expression of polyglutamine-expanded huntingtin by mouse striatal astrocytes impairs glutamate transport: a correlation with Huntington's disease … M Faideau, J Kim, K Cormier, R Gilmore, M Welch, G Auregan, N Dufour, ... Human molecular genetics 19 (15), 3053-3067, 2010 | 355 | 2010 |
Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease N Deglon, JL Tseng, JC Bensadoun, AD Zurn, Y Arsenijevic, ... Human gene therapy 11 (1), 179-190, 2000 | 354 | 2000 |
Mitochondria in Huntington's disease M Damiano, L Galvan, N Déglon, E Brouillet Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1802 (1), 52-61, 2010 | 347 | 2010 |
Connexin 30 sets synaptic strength by controlling astroglial synapse invasion U Pannasch, D Freche, G Dallérac, G Ghézali, C Escartin, P Ezan, ... Nature neuroscience 17 (4), 549-558, 2014 | 338 | 2014 |
Involvement of mitochondrial complex II defects in neuronal death produced by N-terminus fragment of mutated huntingtin A Benchoua, Y Trioulier, D Zala, MC Gaillard, N Lefort, N Dufour, ... Molecular biology of the cell 17 (4), 1652-1663, 2006 | 297 | 2006 |
The JAK/STAT3 pathway is a common inducer of astrocyte reactivity in Alzheimer's and Huntington's diseases LB Haim, K Ceyzériat, MA Carrillo-de Sauvage, F Aubry, G Auregan, ... Journal of Neuroscience 35 (6), 2817-2829, 2015 | 287 | 2015 |
Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: results of a phase I study J Bloch, AC Bachoud-Levi, N Deglon, JP Lefaucheur, L Winkel, S Palfi, ... Human gene therapy 15 (10), 968-975, 2004 | 280 | 2004 |
Neuron-to-neuron wild-type Tau protein transfer through a trans-synaptic mechanism: relevance to sporadic tauopathies S Dujardin, K Lécolle, R Caillierez, S Bégard, N Zommer, C Lachaud, ... Acta neuropathologica communications 2, 1-14, 2014 | 273 | 2014 |
Lentiviral-mediated delivery of mutant huntingtin in the striatum of rats induces a selective neuropathology modulated by polyglutamine repeat size, huntingtin expression … LP De Almeida, CA Ross, D Zala, P Aebischer, N Deglon Journal of Neuroscience 22 (9), 3473-3483, 2002 | 261 | 2002 |
Sustained effects of nonallele‐specific Huntingtin silencing V Drouet, V Perrin, R Hassig, N Dufour, G Auregan, S Alves, G Bonvento, ... Annals of Neurology: Official Journal of the American Neurological …, 2009 | 260 | 2009 |
BDNF overexpression in mouse hippocampal astrocytes promotes local neurogenesis and elicits anxiolytic-like activities G Quesseveur, DJ David, MC Gaillard, P Pla, MV Wu, HT Nguyen, ... Translational psychiatry 3 (4), e253-e253, 2013 | 259 | 2013 |
Lentiviral vectors as a gene delivery system in the mouse midbrain: cellular and behavioral improvements in a 6-OHDA model of Parkinson's disease using GDNF JC Bensadoun, N Déglon, JL Tseng, JL Ridet, AD Zurn, P Aebischer Experimental neurology 164 (1), 15-24, 2000 | 257 | 2000 |
Lentivirally delivered glial cell line-derived neurotrophic factor increases the number of striatal dopaminergic neurons in primate models of nigrostriatal degeneration S Palfi, L Leventhal, Y Chu, SY Ma, M Emborg, R Bakay, N Deglon, ... Journal of Neuroscience 22 (12), 4942-4954, 2002 | 252 | 2002 |
Lentiviral gene transfer to the nonhuman primate brain JH Kordower, J Bloch, SY Ma, Y Chu, S Palfi, BZ Roitberg, M Emborg, ... Experimental neurology 160 (1), 1-16, 1999 | 238 | 1999 |
Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado–Joseph disease I Nascimento-Ferreira, T Santos-Ferreira, L Sousa-Ferreira, G Auregan, ... Brain 134 (5), 1400-1415, 2011 | 236 | 2011 |