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Dinko Rekić
Dinko Rekić
Drug Development Leader at Alexion
Dirección de correo verificada de alexion.com - Página principal
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Acute Exacerbation and Decline in Forced Vital Capacity Are Associated with Increased Mortality in Idiopathic Pulmonary Fibrosis
CBA Paterniti MO, Bi Y, Rekić D, Wang Y, Karimi-Shah BA
Annals of the American Thoracic Society, 2017
1672017
An oral antisense oligonucleotide for PCSK9 inhibition
P Gennemark, K Walter, N Clemmensen, D Rekić, CAM Nilsson, ...
Science Translational Medicine 13 (593), eabe9117, 2021
1022021
Clinical drug–drug interaction evaluations to inform drug use and enable drug access
D Rekić, KS Reynolds, P Zhao, L Zhang, K Yoshida, M Sachar, MP Miller, ...
Journal of pharmaceutical sciences 106 (9), 2214-2218, 2017
782017
In vitro–in vivo extrapolation of metabolism-and transporter-mediated drug–drug interactions—overview of basic prediction methods
K Yoshida, P Zhao, L Zhang, DR Abernethy, D Rekić, KS Reynolds, ...
Journal of pharmaceutical sciences 106 (9), 2209-2213, 2017
742017
Toxicokinetics of mercury after long-term repeated exposure to thimerosal-containing vaccine
L Barregard, D Rekić, M Horvat, L Elmberg, T Lundh, O Zachrisson
Toxicological Sciences 120 (2), 499-506, 2011
642011
In silico prediction of efavirenz and rifampicin drug–drug interaction considering weight and CYP2B6 phenotype
D Rekić, D Röshammar, J Mukonzo, M Ashton
British journal of clinical pharmacology 71 (4), 536-543, 2011
542011
HIVAIDS Patients Display Lower Relative Bioavailability of Efavirenz than Healthy Subjects
JK Mukonzo, S Nanzigu, D Rekić, P Waako, D Roshammar, M Ashton, ...
Clinical pharmacokinetics 50 (8), 531-540, 2011
392011
Bilirubin—A Potential Marker of Drug Exposure in Atazanavir-Based Antiretroviral Therapy
D Rekić, O Clewe, D Röshammar, L Flamholc, A Sönnerborg, ...
The AAPS journal 13 (4), 598-605, 2011
202011
QT prolongation risk assessment in oncology: lessons learned from small‐molecule new drug applications approved during 2011‐2019
S Cohen‐Rabbie, AC Berges, D Rekić, J Parkinson, C Dota, ...
The Journal of Clinical Pharmacology 61 (8), 1106-1117, 2021
142021
AZD8233 antisense oligonucleotide targeting PCSK9 does not prolong QT interval
D Rekić, I Azarov, J Knöchel, V Sokolov, C Nilsson, L Wernevik, D Han, ...
British Journal of Clinical Pharmacology 88 (11), 4839-4844, 2022
132022
Model based design and analysis of phase II HIV-1 trials
D Rekić, D Röshammar, USH Simonsson
Journal of pharmacokinetics and pharmacodynamics 40, 487-496, 2013
122013
Etesian: a phase 2B study of the efficacy, safety and tolerability of Azd8233, a Pcsk9-targeted antisense oligonucleotide, in patients with dyslipidemia
MJ Koren, A Hofherr, J Schumi, D Rekic, J Knochel, CAM Nilsson, ...
Journal of the American College of Cardiology 79 (9_Supplement), 1475-1475, 2022
112022
Pharmacokinetics of roxadustat: a population analysis of 2855 dialysis-and non-dialysis-dependent patients with chronic kidney disease
D Rekić, V Kerbusch-Herben, M Någård, J Chou, J Huang, C Bradley, ...
Clinical Pharmacokinetics 60, 759-773, 2021
112021
Dapagliflozin pharmacokinetics is similar in adults with type 1 and type 2 diabetes mellitus
J Melin, W Tang, D Rekić, B Hamrén, RC Penland, DW Boulton, ...
The Journal of Clinical Pharmacology 62 (10), 1227-1235, 2022
92022
A semi-mechanistic exposure–response model to assess the effects of verinurad, a potent URAT1 inhibitor, on serum and urine uric acid in patients with hyperuricemia-associated …
J Leander, M Sunnåker, D Rekić, S Aksenov, UG Eriksson, S Johansson, ...
Journal of Pharmacokinetics and Pharmacodynamics 48, 525-541, 2021
92021
A disease progression model of longitudinal lung function decline in idiopathic pulmonary fibrosis patients
Y Bi, D Rekić, MO Paterniti, J Chen, A Marathe, BA Chowdhury, ...
Journal of pharmacokinetics and pharmacodynamics 48, 55-67, 2021
82021
A case‐study of model‐informed drug development of a novel PCSK9 anti sense oligonucleotide. Part 1: First time in man to phase II
J Knöchel, C Nilsson, B Carlsson, L Wernevik, A Hofherr, P Gennemark, ...
CPT: pharmacometrics & systems pharmacology 11 (12), 1569-1577, 2022
62022
Bilirubin levels and kidney function decline: An analysis of clinical trial and real world data
Y Aoki, CS Cabrera, M Ouwens, K Bamberg, J Nyström, I Raz, BM Scirica, ...
Plos one 17 (6), e0269970, 2022
62022
Concentration‐QT modelling in early clinical oncology settings: Simulation evaluation of performance
G Cantet, A Berges, R O'Sullivan, S Cohen‐Rabbie, C Dota, V Dubois, ...
British Journal of Clinical Pharmacology 88 (3), 1010-1019, 2022
52022
Concentration‐QT modelling shows no evidence of clinically significant QT interval prolongation with capivasertib at expected therapeutic concentrations
V Voronova, M Cullberg, P Delff, J Parkinson, C Dota, G Schiavon, ...
British Journal of Clinical Pharmacology 88 (2), 858-864, 2022
52022
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