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Abhirup Das
Abhirup Das
Merck
Dirección de correo verificada de unsw.edu.au
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Impairment of an endothelial NAD+-H2S signaling network is a reversible cause of vascular aging
A Das, GX Huang, MS Bonkowski, A Longchamp, C Li, MB Schultz, ...
Cell 173 (1), 74-89. e20, 2018
4322018
Loss of epigenetic information as a cause of mammalian aging
JH Yang, M Hayano, PT Griffin, JA Amorim, MS Bonkowski, ...
Cell 186 (2), 305-326. e27, 2023
3542023
Amino acid restriction triggers angiogenesis via GCN2/ATF4 regulation of VEGF and H2S production
A Longchamp, T Mirabella, A Arduini, MR MacArthur, A Das, ...
Cell 173 (1), 117-129. e14, 2018
2972018
SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive
S Libert, K Pointer, EL Bell, A Das, DE Cohen, JM Asara, K Kapur, ...
Cell 147 (7), 1459-1472, 2011
2812011
Biosynthesis of aromatic polyketides in bacteria
A Das, C Khosla
Accounts of chemical research 42 (5), 631-639, 2009
2072009
Acid‐sensing ion channels regulate nucleus pulposus cell inflammation and pyroptosis via the NLRP3 inflammasome in intervertebral disc degeneration
K Zhao, R An, Q Xiang, G Li, K Wang, Y Song, Z Liao, S Li, W Hua, X Feng, ...
Cell proliferation 54 (1), e12941, 2021
1532021
A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism
N Turner, XY Lim, HD Toop, B Osborne, AE Brandon, EN Taylor, ...
Nature communications 9 (1), 3165, 2018
1282018
Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age‐related insulin resistance
M Mohamad, SJ Mitchell, LE Wu, MY White, SJ Cordwell, J Mach, ...
Aging Cell 15 (4), 706-715, 2016
742016
Evidence for Transcriptional Regulation of the Glucose-6-Phosphate Transporter by HIF-1α: Targeting G6PT with Mumbaistatin Analogs in Hypoxic Mesenchymal …
S Lord-Dufour, IB Copland, LC Levros Jr, M Post, A Das, C Khosla, ...
Stem Cells 27 (3), 489-497, 2009
642009
Degenerative cervical myelopathy: insights into its pathobiology and molecular mechanisms
J Tu, J Vargas Castillo, A Das, AD Diwan
Journal of Clinical Medicine 10 (6), 1214, 2021
622021
Gut-disc axis: A cause of intervertebral disc degeneration and low back pain?
W Li, K Lai, N Chopra, Z Zheng, A Das, AD Diwan
European Spine Journal 31 (4), 917-925, 2022
482022
Impairment of an endothelial NAD+-H2S signaling network is a reversible cause of vascular aging
A Das, GX Huang, MS Bonkowski, A Longchamp, C Li, MB Schultz, ...
Cell 176 (4), 944-945, 2019
432019
DNA break-induced epigenetic drift as a cause of mammalian aging
M Hayano, JH Yang, MS Bonkowski, JA Amorim, JM Ross, G Coppotelli, ...
BioRxiv, 808659, 2019
412019
In vivo and in vitro analysis of the hedamycin polyketide synthase
A Das, C Khosla
Chemistry & biology 16 (11), 1197-1207, 2009
362009
Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes
MKH Chowdhury, N Turner, NL Bentley, A Das, LE Wu, D Richani, ...
Scientific reports 7 (1), 40159, 2017
322017
Structural and Biochemical Studies of the Hedamycin Type II Polyketide Ketoreductase (HedKR): Molecular Basis of Stereo- and Regiospecificities
P Javidpour, A Das, C Khosla, SC Tsai
Biochemistry 50 (34), 7426-7439, 2011
322011
Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice
NA Youngson, GM Uddin, A Das, C Martinez, HS Connaughton, S Whiting, ...
Reproduction 158 (2), 169-179, 2019
272019
Mechanism and engineering of polyketide chain initiation in fredericamycin biosynthesis
A Das, PH Szu, JT Fitzgerald, C Khosla
Journal of the American Chemical Society 132 (26), 8831-8833, 2010
252010
Analysis of the ketosynthase-chain length factor heterodimer from the fredericamycin polyketide synthase
PH Szu, S Govindarajan, MJ Meehan, A Das, DD Nguyen, PC Dorrestein, ...
Chemistry & biology 18 (8), 1021-1031, 2011
232011
The REDD1/TXNIP Complex Accelerates Oxidative Stress‐Induced Apoptosis of Nucleus Pulposus Cells through the Mitochondrial Pathway
H Yin, K Wang, A Das, G Li, Y Song, R Luo, JPY Cheung, T Zhang, S Li, ...
Oxidative Medicine and Cellular Longevity 2021 (1), 7397516, 2021
222021
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