| Function, therapeutic potential, and inhibition of Hsp70 chaperones AJ Ambrose, E Chapman Journal of Medicinal Chemistry 64 (11), 7060-7082, 2021 | 55 | 2021 |
| Target-Based Screening against eIF4A1 Reveals the Marine Natural Product Elatol as a Novel Inhibitor of Translation Initiation with In Vivo Antitumor Activity TL Peters, J Tillotson, AM Yeomans, S Wilmore, E Lemm, ... Clinical Cancer Research 24 (17), 4256-4270, 2018 | 47 | 2018 |
| Sulfonamido-2-arylbenzoxazole GroEL/ES Inhibitors as Potent Antibacterials against Methicillin-Resistant Staphylococcus aureus (MRSA) S Abdeen, T Kunkle, N Salim, AM Ray, N Mammadova, C Summers, ... Journal of medicinal chemistry 61 (16), 7345-7357, 2018 | 42 | 2018 |
| GroEL/ES inhibitors as potential antibiotics S Abdeen, N Salim, N Mammadova, CM Summers, R Frankson, ... Bioorganic & medicinal chemistry letters 26 (13), 3127-3134, 2016 | 42 | 2016 |
| Increased O-GlcNAcylation of SNAP29 drives arsenic-induced autophagic dysfunction M Dodson, P Liu, T Jiang, AJ Ambrose, G Luo, M Rojo de la Vega, ... Molecular and cellular biology 38 (11), e00595-17, 2018 | 39 | 2018 |
| ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A J Tillotson, M Kedzior, L Guimarães, AB Ross, TL Peters, AJ Ambrose, ... Bioorganic & medicinal chemistry letters 27 (17), 4082-4085, 2017 | 36 | 2017 |
| Hydroxybiphenylamide GroEL/ES Inhibitors Are Potent Antibacterials against Planktonic and Biofilm Forms of Staphylococcus aureus T Kunkle, S Abdeen, N Salim, AM Ray, M Stevens, AJ Ambrose, ... Journal of medicinal chemistry 61 (23), 10651-10664, 2018 | 29 | 2018 |
| Ritterostatin GN1N, a Cephalostatin–Ritterazine Bis‐steroidal Pyrazine Hybrid, Selectively Targets GRP78 AJ Ambrose, EA Santos, PC Jimenez, DD Rocha, DV Wilke, P Beuzer, ... ChemBioChem 18 (6), 506-510, 2017 | 25 | 2017 |
| The Hybrid Pyrroloisoindolone–Dehydropyrrolizine Alkaloid (−)‐Chlorizidine A Targets Proteins within the Glycolytic Pathway X Álvarez‐Micó, DD Rocha, LA Guimarães, A Ambrose, E Chapman, ... ChemBioChem 16 (14), 2002-2006, 2015 | 21 | 2015 |
| A high throughput substrate binding assay reveals hexachlorophene as an inhibitor of the ER-resident HSP70 chaperone GRP78 AJ Ambrose, CJ Zerio, J Sivinski, CJ Schmidlin, T Shi, AB Ross, ... Bioorganic & medicinal chemistry letters 29 (14), 1689-1693, 2019 | 20 | 2019 |
| Copper Chaperone CupA and Zinc Control CopY Regulation of the Pneumococcal cop Operon MJ Neubert, EA Dahlmann, A Ambrose, MDL Johnson Msphere 2 (5), 10.1128/msphere. 00372-17, 2017 | 20 | 2017 |
| Heat shock protein Grp78/BiP/HspA5 binds directly to TDP-43 and mitigates toxicity associated with disease pathology L François-Moutal, DD Scott, AJ Ambrose, CJ Zerio, ... Scientific reports 12 (1), 8140, 2022 | 17 | 2022 |
| Arsenic compromises both p97 and proteasome functions J Tillotson, CJ Zerio, B Harder, AJ Ambrose, KS Jung, MJ Kang, ... Chemical research in toxicology 30 (7), 1508-1514, 2017 | 17 | 2017 |
| Unfolded DapA forms aggregates when diluted into free solution, confounding comparison with folding by the GroEL/GroES chaperonin system AJ Ambrose, W Fenton, DJ Mason, E Chapman, AL Horwich FEBS letters 589 (4), 497-499, 2015 | 13 | 2015 |
| A chemical biology approach to model pontocerebellar hypoplasia type 1B (PCH1B) L François-Moutal, S Jahanbakhsh, ADL Nelson, D Ray, DD Scott, ... ACS chemical biology 13 (10), 3000-3010, 2018 | 12 | 2018 |
| Identification of pyrazine-based TrkA inhibitors: design, synthesis, evaluation, and computational modeling studies B Frett, N McConnell, Y Wang, Z Xu, A Ambrose, H Li MedChemComm 5 (10), 1507-1514, 2014 | 12 | 2014 |
| Caspase‐6‐cleaved tau is relevant in Alzheimer's disease and marginal in four‐repeat tauopathies: Diagnostic and therapeutic implications P Theofilas, AMH Piergies, I Oh, YB Lee, SH Li, FL Pereira, C Petersen, ... Neuropathology and applied neurobiology 48 (5), e12819, 2022 | 11 | 2022 |
| One-Step Synthesis of Thieno[2,3-d]pyrimidin-4(3H)-ones via a Catalytic Four-Component Reaction of Ketones, Ethyl Cyanoacetate, S8, and Formamide T Shi, L Kaneko, M Sandino, R Busse, M Zhang, D Mason, J Machulis, ... ACS sustainable chemistry & engineering 7 (1), 1524-1528, 2018 | 11 | 2018 |
| Functional differences between E. Coli and eskape pathogen groes/groel J Sivinski, AJ Ambrose, I Panfilenko, CJ Zerio, JM Machulis, N Mollasalehi, ... Mbio 12 (1), 10.1128/mbio. 02167-20, 2021 | 9 | 2021 |
| An isoform-selective PTP1B inhibitor derived from nitrogen-atom augmentation of radicicol T Shi, EMK Wijeratne, C Solano, AJ Ambrose, AB Ross, C Norwood, ... Biochemistry 58 (30), 3225-3231, 2019 | 9 | 2019 |
