| Efficient endoderm induction from human pluripotent stem cells by logically directing signals controlling lineage bifurcations KM Loh, LT Ang, J Zhang, V Kumar, J Ang, JQ Auyeong, KL Lee, ... Cell stem cell 14 (2), 237-252, 2014 | 425 | 2014 |
| Generating specificity and diversity in the transcriptional response to hypoxia U Lendahl, KL Lee, H Yang, L Poellinger Nature Reviews Genetics 10 (12), 821-832, 2009 | 417 | 2009 |
| S-2-hydroxyglutarate regulates CD8+ T-lymphocyte fate PA Tyrakis, A Palazon, D Macias, KL Lee, AT Phan, P Veliça, J You, ... Nature 540 (7632), 236-241, 2016 | 385 | 2016 |
| Arkadia induces degradation of SnoN and c-Ski to enhance transforming growth factor-β signaling Y Nagano, KJ Mavrakis, KL Lee, T Fujii, D Koinuma, H Sase, K Yuki, ... Journal of Biological Chemistry 282 (28), 20492-20501, 2007 | 206 | 2007 |
| A roadmap for human liver differentiation from pluripotent stem cells LT Ang, AKY Tan, MI Autio, SH Goh, SH Choo, KL Lee, J Tan, B Pan, ... Cell reports 22 (8), 2190-2205, 2018 | 187 | 2018 |
| Non-canonical Notch signaling activates IL-6/JAK/STAT signaling in breast tumor cells and is controlled by p53 and IKKα/IKKβ S Jin, AP Mutvei, IV Chivukula, ER Andersson, D Ramsköld, R Sandberg, ... Oncogene 32 (41), 4892-4902, 2013 | 156 | 2013 |
| Heparan sulfation–dependent fibroblast growth factor signaling maintains embryonic stem cells primed for differentiation in a heterogeneous state F Lanner, KL Lee, M Sohl, K Holmborn, H Yang, J Wilbertz, L Poellinger, ... Stem cells 28 (2), 191-200, 2010 | 143 | 2010 |
| A human pluripotent stem cell model of facioscapulohumeral muscular dystrophy-affected skeletal muscles L Caron, D Kher, KL Lee, R McKernan, B Dumevska, A Hidalgo, J Li, ... Stem Cells Translational Medicine 5 (9), 1145-1161, 2016 | 123 | 2016 |
| Arkadia enhances Nodal/TGF-β signaling by coupling phospho-Smad2/3 activity and turnover KJ Mavrakis, RL Andrew, KL Lee, C Petropoulou, JE Dixon, ... PLoS Biology 5 (3), e67, 2007 | 120 | 2007 |
| Graded Nodal/Activin signaling titrates conversion of quantitative phospho-Smad2 levels into qualitative embryonic stem cell fate decisions KL Lee, SK Lim, YL Orlov, LY Yit, H Yang, LT Ang, L Poellinger, B Lim PLoS genetics 7 (6), e1002130, 2011 | 104 | 2011 |
| Down-regulation of Myc is essential for terminal erythroid maturation SR Jayapal, KL Lee, P Ji, P Kaldis, B Lim, HF Lodish Journal of Biological Chemistry 285 (51), 40252-40265, 2010 | 103 | 2010 |
| Physiologic hypoxia promotes maintenance of CML stem cells despite effective BCR-ABL1 inhibition KP Ng, A Manjeri, KL Lee, W Huang, SY Tan, CTH Chuah, L Poellinger, ... Blood, The Journal of the American Society of Hematology 123 (21), 3316-3326, 2014 | 102 | 2014 |
| Selective inhibition of unfolded protein response induces apoptosis in pancreatic cancer cells W Chien, LW Ding, QY Sun, LA Torres-Fernandez, SZ Tan, J Xiao, SL Lim, ... Oncotarget 5 (13), 4881, 2014 | 92 | 2014 |
| Hypoxia is a key driver of alternative splicing in human breast cancer cells J Han, J Li, JC Ho, GS Chia, H Kato, S Jha, H Yang, L Poellinger, KL Lee Scientific reports 7 (1), 4108, 2017 | 81 | 2017 |
| Activation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer W Chien, QY Sun, KL Lee, LW Ding, P Wuensche, LA Torres-Fernandez, ... Molecular Oncology 9 (4), 889-905, 2015 | 81 | 2015 |
| The hypoxia-inducible epigenetic regulators Jmjd1a and G9a provide a mechanistic link between angiogenesis and tumor growth J Ueda, JC Ho, KL Lee, S Kitajima, H Yang, W Sun, N Fukuhara, N Zaiden, ... Molecular and cellular biology 34 (19), 3702-3720, 2014 | 65 | 2014 |
| An integrative model of pathway convergence in genetically heterogeneous blast crisis chronic myeloid leukemia TK Ko, A Javed, KL Lee, TN Pathiraja, X Liu, S Malik, SX Soh, XT Heng, ... Blood, The Journal of the American Society of Hematology 135 (26), 2337-2353, 2020 | 61 | 2020 |
| Graded Smad2/3 activation is converted directly into levels of target gene expression in embryonic stem cells M Guzman-Ayala, KL Lee, KJ Mavrakis, P Goggolidou, DP Norris, ... PLoS One 4 (1), e4268, 2009 | 59 | 2009 |
| Interactions between Notch-and hypoxia-induced transcriptomes in embryonic stem cells H Main, KL Lee, H Yang, S Haapa-Paananen, H Edgren, S Jin, ... Experimental cell research 316 (9), 1610-1624, 2010 | 48 | 2010 |
| The A Allele at rs13419896 of EPAS1 is associated with enhanced expression and poor prognosis for non-small cell lung cancer AC Putra, H Eguchi, KL Lee, Y Yamane, E Gustine, T Isobe, M Nishiyama, ... PloS one 10 (8), e0134496, 2015 | 45 | 2015 |
