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Luca Ponzoni
Luca Ponzoni
Relay Therapeutics
Dirección de correo verificada de relaytx.com - Página principal
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Structural dynamics is a determinant of the functional significance of missense variants
L Ponzoni, I Bahar
Biophysical Journal 114 (3), 232a, 2018
922018
Rhapsody: predicting the pathogenicity of human missense variants
L Ponzoni, DA Peñaherrera, ZN Oltvai, I Bahar
Bioinformatics 36 (10), 3084-3092, 2020
892020
SPECTRUS: A dimensionality reduction approach for identifying dynamical domains in protein complexes from limited structural datasets
L Ponzoni, G Polles, V Carnevale, C Micheletti
Structure 23 (8), 1516-1525, 2015
452015
Patterns of coevolving amino acids unveil structural and dynamical domains
D Granata, L Ponzoni, C Micheletti, V Carnevale
Proceedings of the National Academy of Sciences 114 (50), E10612-E10621, 2017
402017
Shared dynamics of LeuT superfamily members and allosteric differentiation by structural irregularities and multimerization
L Ponzoni, S Zhang, MH Cheng, I Bahar
Philosophical Transactions of the Royal Society B: Biological Sciences 373 …, 2018
282018
Prioritizing virtual screening with interpretable interaction fingerprints
AV Fassio, L Shub, L Ponzoni, J McKinley, MJ O’Meara, RS Ferreira, ...
Journal of Chemical Information and Modeling 62 (18), 4300-4318, 2022
262022
EIF3H orchestrates Hippo pathway–mediated oncogenesis via catalytic control of YAP stability
Z Zhou, H Zhou, L Ponzoni, A Luo, R Zhu, M He, Y Huang, KL Guan, ...
Cancer research 80 (12), 2550-2563, 2020
262020
The interplay between structural stability and plasticity determines mutation profiles and chaperone dependence in protein kinases
A Paladino, F Marchetti, L Ponzoni, G Colombo
Journal of Chemical Theory and Computation 14 (2), 1059-1070, 2018
152018
Trimerization of dopamine transporter triggered by AIM-100 binding: Molecular mechanism and effect of mutations
MH Cheng, L Ponzoni, T Sorkina, JY Lee, S Zhang, A Sorkin, I Bahar
Neuropharmacology 161, 107676, 2019
142019
Unifying view of mechanical and functional hotspots across class A GPCRs
L Ponzoni, G Rossetti, L Maggi, A Giorgetti, P Carloni, C Micheletti
PLoS computational biology 13 (2), e1005381, 2017
142017
Complementary computational and experimental evaluation of missense variants in the ROMK potassium channel
L Ponzoni, NH Nguyen, I Bahar, JL Brodsky
PLoS Computational Biology 16 (4), e1007749, 2020
92020
Rhapsody: Pathogenicity prediction of human missense variants based on protein sequence, structure and dynamics
L Ponzoni, ZN Oltvai, I Bahar
bioRxiv, 737429, 2019
32019
Focusing in multiwell potentials: applications to ion channels
L Ponzoni, GL Celardo, F Borgonovi, L Kaplan, A Kargol
Physical Review E—Statistical, Nonlinear, and Soft Matter Physics 87 (5 …, 2013
32013
From Sequence to Function: Coevolving Amino Acids Encode Structural and Functional Domains
D Granata, L Ponzoni, C Micheletti, V Carnevale
bioRxiv, 109397, 2017
2017
Knowledge-based identification of functional domains in proteins
L Ponzoni
SISSA, 2016
2016
A general approach to identify innate dynamical domains in proteins from limited structural datasets
L Ponzoni, G Polles, V Carnevale, C Micheletti
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 44, S61-S61, 2015
2015
Focusing in Multi-Well Potentials: Application to Ion Channels
F Borgonovi, GL Celardo, L Ponzoni
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Artículos 1–17