Hypoxic pulmonary vasoconstriction: from molecular mechanisms to medicine KJ Dunham-Snary, D Wu, EA Sykes, A Thakrar, LRG Parlow, JD Mewburn, ... Chest 151 (1), 181-192, 2017 | 477 | 2017 |
MicroRNA-138 and microRNA-25 down-regulate mitochondrial calcium uniporter, causing the pulmonary arterial hypertension cancer phenotype Z Hong, KH Chen, A DasGupta, F Potus, K Dunham-Snary, S Bonnet, ... American journal of respiratory and critical care medicine 195 (4), 515-529, 2017 | 150 | 2017 |
Epigenetic dysregulation of the dynamin-related protein 1 binding partners MiD49 and MiD51 increases mitotic mitochondrial fission and promotes pulmonary arterial hypertension … KH Chen, A Dasgupta, J Lin, F Potus, S Bonnet, J Iremonger, J Fu, ... Circulation 138 (3), 287-304, 2018 | 138 | 2018 |
Mitochondrial fission links ECM mechanotransduction to metabolic redox homeostasis and metastatic chemotherapy resistance P Romani, N Nirchio, M Arboit, V Barbieri, A Tosi, F Michielin, S Shibuya, ... Nature cell biology 24 (2), 168-180, 2022 | 113 | 2022 |
Epigenetic metabolic reprogramming of right ventricular fibroblasts in pulmonary arterial hypertension: a pyruvate dehydrogenase kinase-dependent shift in mitochondrial … L Tian, D Wu, A Dasgupta, KH Chen, J Mewburn, F Potus, PDA Lima, ... Circulation research 126 (12), 1723-1745, 2020 | 113 | 2020 |
Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension L Tian, M Neuber-Hess, J Mewburn, A Dasgupta, K Dunham-Snary, D Wu, ... Journal of molecular medicine 95, 381-393, 2017 | 107 | 2017 |
Ndufs2, a core subunit of mitochondrial complex I, is essential for acute oxygen-sensing and hypoxic pulmonary vasoconstriction KJ Dunham-Snary, D Wu, F Potus, EA Sykes, JD Mewburn, RL Charles, ... Circulation research 124 (12), 1727-1746, 2019 | 89 | 2019 |
Identification of novel dynamin‐related protein 1 (Drp1) GTPase inhibitors: therapeutic potential of Drpitor1 and Drpitor1a in cancer and cardiac ischemia‐reperfusion injury D Wu, A Dasgupta, KH Chen, M Neuber‐Hess, J Patel, TE Hurst, ... The FASEB Journal 34 (1), 1447-1464, 2020 | 88 | 2020 |
Increased Drp1-mediated mitochondrial fission promotes proliferation and collagen production by right ventricular fibroblasts in experimental pulmonary arterial hypertension L Tian, F Potus, D Wu, A Dasgupta, KH Chen, J Mewburn, P Lima, ... Frontiers in physiology 9, 828, 2018 | 79 | 2018 |
Macrophage–NLRP3 activation promotes right ventricle failure in pulmonary arterial hypertension R Al-Qazazi, PDA Lima, SZ Prisco, F Potus, A Dasgupta, KH Chen, L Tian, ... American journal of respiratory and critical care medicine 206 (5), 608-624, 2022 | 78 | 2022 |
The phosphodiesterase-5 inhibitor vardenafil reduces oxidative stress while reversing pulmonary arterial hypertension YF Fan, R Zhang, X Jiang, L Wen, DC Wu, D Liu, P Yuan, YL Wang, ... Cardiovascular research 99 (3), 395-403, 2013 | 68 | 2013 |
Colchicine depolymerizes microtubules, increases junctophilin‐2, and improves right ventricular function in experimental pulmonary arterial hypertension KW Prins, L Tian, D Wu, T Thenappan, JM Metzger, SL Archer Journal of the American Heart Association 6 (6), e006195, 2017 | 64 | 2017 |
Mitochondria in the pulmonary vasculature in health and disease: oxygen-sensing, metabolism, and dynamics A Dasgupta, D Wu, L Tian, PY Xiong, KJ Dunham-Snary, KH Chen, ... Comprehensive physiology 10 (2), 713-765, 2020 | 54 | 2020 |
Identifying microRNAs targeting Wnt/β-catenin pathway in end-stage idiopathic pulmonary arterial hypertension D Wu, CCJ Talbot, Q Liu, ZC Jing, RL Damico, R Tuder, KC Barnes, ... J Mol Med (Berl), 2016 | 48 | 2016 |
Effects of Pinus massoniana bark extract on the adhesion and migration capabilities of HeLa cells DC Wu, S Li, DQ Yang, YY Cui Fitoterapia 82 (8), 1202-1205, 2011 | 46 | 2011 |
Oxygen sensing, mitochondrial biology and experimental therapeutics for pulmonary hypertension and cancer D Wu, A Dasgupta, AD Read, RET Bentley, M Motamed, KH Chen, ... Free Radical Biology and Medicine 170, 150-178, 2021 | 45 | 2021 |
Clinical value of non-coding RNAs in cardiovascular, pulmonary, and muscle diseases S Bonnet, O Boucherat, R Paulin, D Wu, CCT Hindmarch, SL Archer, ... American Journal of Physiology-Cell Physiology 318 (1), C1-C28, 2020 | 37 | 2020 |
PINK1 induced phosphorylation of mitofusin 2 (Mfn2) at serine 442 causes its proteasomal degradation and promotes cell proliferation in lung cancer and pulmonary arterial … A Dasgupta, KH Chen, PDA Lima, J Mewburn, D Wu, R Al-Qazazi, ... FASEB journal: official publication of the Federation of American Societies …, 2021 | 35 | 2021 |
SARS-CoV-2 mitochondriopathy in COVID-19 pneumonia exacerbates hypoxemia SL Archer, A Dasgupta, KH Chen, D Wu, K Baid, JE Mamatis, V Gonzalez, ... Redox Biology 58, 102508, 2022 | 32 | 2022 |
Excess protein O-GlcNAcylation links metabolic derangements to right ventricular dysfunction in pulmonary arterial hypertension SZ Prisco, L Rose, F Potus, L Tian, D Wu, L Hartweck, R Al-Qazazi, ... International journal of molecular sciences 21 (19), 7278, 2020 | 21 | 2020 |