| Structure–activity studies on the spiroketal moiety of a simplified analogue of debromoaplysiatoxin with antiproliferative activity M Kikumori, RC Yanagita, H Tokuda, N Suzuki, H Nagai, K Suenaga, ... Journal of Medicinal Chemistry 55 (11), 5614-5626, 2012 | 59 | 2012 |
| A New Lyngbyatoxin from the Hawaiian Cyanobacterium Moorea producens W Jiang, W Zhou, H Uchida, M Kikumori, K Irie, R Watanabe, T Suzuki, ... Marine Drugs 12 (5), 2748-2759, 2014 | 46 | 2014 |
| Effects of the methoxy group in the side chain of debromoaplysiatoxin on its tumor-promoting and anti-proliferative activities RC Yanagita, H Kamachi, M Kikumori, H Tokuda, N Suzuki, K Suenaga, ... Bioorganic & medicinal chemistry letters 23 (15), 4319-4323, 2013 | 22 | 2013 |
| Improved and large-scale synthesis of 10-methyl-aplog-1, a potential lead for an anticancer drug M Kikumori, RC Yanagita, K Irie Tetrahedron 70 (52), 9776-9782, 2014 | 21 | 2014 |
| Structure–activity studies at position 27 of aplog-1, a simplified analog of debromoaplysiatoxin with anti-proliferative activity Y Hanaki, M Kikumori, S Ueno, H Tokuda, N Suzuki, K Irie Tetrahedron 69 (36), 7636-7645, 2013 | 20 | 2013 |
| Synthesis and biological evaluation of the 12, 12-dimethyl derivative of Aplog-1, an anti-proliferative analog of tumor-promoting aplysiatoxin Y Nakagawa, M Kikumori, RC Yanagita, A Murakami, H Tokuda, H Nagai, ... Bioscience, biotechnology, and biochemistry 75 (6), 1167-1173, 2011 | 19 | 2011 |
| Synthesis and structure–activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1 K Irie, M Kikumori, H Kamachi, K Tanaka, A Murakami, RC Yanagita, ... Pure and Applied Chemistry 84 (6), 1341-1351, 2012 | 18 | 2012 |
| Identification of protein kinase C isozymes involved in the anti-proliferative and pro-apoptotic activities of 10-Methyl-aplog-1, a simplified analog of debromoaplysiatoxin, in … Y Hanaki, Y Shikata, M Kikumori, N Hotta, M Imoto, K Irie Biochemical and biophysical research communications 495 (1), 438-445, 2018 | 17 | 2018 |
| Structural optimization of 10-methyl-aplog-1, a simplified analog of debromoaplysiatoxin, as an anticancer lead M Kikumori, RC Yanagita, H Tokuda, K Suenaga, H Nagai, K Irie Bioscience, Biotechnology, and Biochemistry 80 (2), 221-231, 2016 | 17 | 2016 |
| The novel PKC activator 10-methyl-aplog-1 combined with JQ1 induced strong and synergistic HIV reactivation with tolerable global T cell activation A Washizaki, M Murata, Y Seki, M Kikumori, Y Tang, W Tan, NP Wardani, ... Viruses 13 (10), 2037, 2021 | 8 | 2021 |
| Loss of the phenolic hydroxyl group and aromaticity from the side chain of anti-proliferative 10-Methyl-aplog-1, a simplified analog of aplysiatoxin, enhances its tumor … Y Hanaki, M Kikumori, H Tokuda, M Okamura, S Dan, N Adachi, N Saito, ... Molecules 22 (4), 631, 2017 | 7 | 2017 |
| In vivo anti-cancer activity of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, and its possible signaling pathway associated with G1 arrest Y Hanaki, Y Shikata, M Kikumori, M Okamura, S Dan, M Imoto, K Irie Biochemical and Biophysical Research Communications 675, 19-25, 2023 | 2 | 2023 |
| Biological evaluation of a phosphate ester prodrug of 10-methyl-aplog-1, a simplified analog of aplysiatoxin, as a possible latency-reversing agent for HIV reactivation J Maki, Y Hanaki, RC Yanagita, M Kikumori, A Kovba, A Washizaki, ... Bioscience, Biotechnology, and Biochemistry 87 (12), 1453-1461, 2023 | 1 | 2023 |
| Structural Optimization of a Simplified Analog of Aplysiatoxin as a Potential Seed for Anticancer Drugs M Kikumori Kyoto University, 2015 | | 2015 |
| A new lyngbyatoxin from the Hawaiian cyanobacterium Moorea producens. JWN Jiang WeiNa, ZW Zhou Wei, H Uchida, M Kikumori, K Irie, ... | | 2014 |
