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Stephanie M McTighe
Stephanie M McTighe
Associate Director, Arkuda Therapeutics
Verified email at arkudatx.com
Title
Cited by
Cited by
Year
Paradoxical false memory for objects after brain damage
SM McTighe, RA Cowell, BD Winters, TJ Bussey, LM Saksida
Science 330 (6009), 1408-1410, 2010
1702010
CLK2 inhibition ameliorates autistic features associated with SHANK3 deficiency
M Bidinosti, P Botta, S Krüttner, CC Proenca, N Stoehr, M Bernhard, I Fruh, ...
Science 351 (6278), 1199-1203, 2016
1562016
The BTBR mouse model of autism spectrum disorders has learning and attentional impairments and alterations in acetylcholine and kynurenic acid in prefrontal cortex
SM McTighe, SJ Neal, Q Lin, ZA Hughes, DG Smith
PloS one 8 (4), e62189, 2013
1392013
Trial-unique, delayed nonmatching-to-location (TUNL): a novel, highly hippocampus-dependent automated touchscreen test of location memory and pattern separation
JC Talpos, SM McTighe, R Dias, LM Saksida, TJ Bussey
Neurobiology of learning and memory 94 (3), 341-352, 2010
1332010
A new touchscreen test of pattern separation: effect of hippocampal lesions
SM McTighe, AC Mar, C Romberg, TJ Bussey, LM Saksida
Neuroreport 20 (9), 881-885, 2009
1282009
False recognition in a mouse model of Alzheimer’s disease: rescue with sensory restriction and memantine
C Romberg, SM McTighe, CJ Heath, DJ Whitcomb, K Cho, TJ Bussey, ...
Brain 135 (7), 2103-2114, 2012
632012
Emerging gene and small molecule therapies for the neurodevelopmental disorder angelman syndrome
NA Copping, SM McTighe, KD Fink, JL Silverman
Neurotherapeutics 18 (3), 1535-1547, 2021
262021
Discovery of a brain-penetrant ATP-competitive inhibitor of the mechanistic target of rapamycin (mTOR) for CNS disorders
S Bonazzi, CP Goold, A Gray, NM Thomsen, J Nunez, RG Karki, A Gorde, ...
Journal of Medicinal Chemistry 63 (3), 1068-1083, 2020
262020
FK962 and donepezil act synergistically to improve cognition in rats: potential as an add-on therapy for Alzheimer's disease
AD McCarthy, IJ Owens, AT Bansal, SM McTighe, TJ Bussey, LM Saksida
Pharmacology Biochemistry and Behavior 98 (1), 76-80, 2011
212011
Genetic background and sex: impact on generalizability of research findings in pharmacology studies
SJ Sukoff Rizzo, S McTighe, DL McKinzie
Good Research Practice in Non-Clinical Pharmacology and Biomedicine, 147-162, 2020
172020
Translational neuroimaging: tools for CNS drug discovery, development and treatment
RA McArthur
Academic Press, 2012
102012
A new touchscreen test of pattern separation: Effect of hippocampal lesions. NeuroReport: For Rapid Communication of Neuroscience Research, 20 (9), 881–885
SM McTighe, AC Mar, C Romberg, TJ Bussey, LM Saksida
102009
Discovery and characterization of novel TRPML1 agonists
X Peng, CJ Holler, AMF Alves, MG Oliviera, M Speake, A Pugliese, ...
Bioorganic & Medicinal Chemistry Letters 98, 129595, 2024
22024
Seizure reduction in TSC2‐mutant mouse model by an mTOR catalytic inhibitor
SC Dhamne, ME Modi, A Gray, S Bonazzi, L Craig, E Bainbridge, L Lalani, ...
Annals of clinical and translational neurology 10 (10), 1790-1801, 2023
22023
Translational neuroimaging for drug discovery and development in autism spectrum disorders: guidance from clinical imaging and preclinical research
LL Badura, MD Saxe, C Risterucci, MJ Brammer, SM McTighe, RH Ring, ...
Translational Neuroimaging, 245-280, 2013
22013
ARKD‐104, A Potential Treatment of Frontotemporal Dementia and Other Neurodegenerative Disorders
SW Hung, RS Hurst, JF Blain, CJ Holler, AYP Chen, MA Brand, AM Alves, ...
Alzheimer's & Dementia 19, e074362, 2023
2023
Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes
S Bonazzi, A Gray, NM Thomsen, J Biag, N Labbe-Giguere, EP Keaney, ...
Journal of Medicinal Chemistry 66 (13), 9095-9119, 2023
2023
Translational Neuroimaging for Drug Discovery and Development in Autism Spectrum Disorders
LL Badura, MD Saxe, C Risterucci, MJ Brammer, SM McTighe, RH Ring, ...
Tools for CNS Drug Discovery, Development and Treatment, 245, 2012
2012
Mechanisms of memory and pattern separation in rodent models of amnesia and dementia
SM McTighe
University of Cambridge, 2012
2012
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Articles 1–19