PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein T Mochizuki, G Wu, T Hayashi, SL Xenophontos, B Veldhuisen, JJ Saris, ... Science 272 (5266), 1339-1342, 1996 | 1770 | 1996 |
Polycystin-2 is an intracellular calcium release channel P Koulen, Y Cai, L Geng, Y Maeda, S Nishimura, R Witzgall, BE Ehrlich, ... Nature cell biology 4 (3), 191-197, 2002 | 855 | 2002 |
PKD1 interacts with PKD2 through a probable coiled-coil domain F Qian, FJ Germino, Y Cai, X Zhang, S Somlo, GG Germino Nature genetics 16 (2), 179-183, 1997 | 810 | 1997 |
Somatic inactivation of Pkd2 results in polycystic kidney disease G Wu, V D'Agati, Y Cai, G Markowitz, JH Park, DM Reynolds, Y Maeda, ... Cell 93 (2), 177-188, 1998 | 637 | 1998 |
Cardiac defects and renal failure in mice with targeted mutations in Pkd2 G Wu, GS Markowitz, L Li, VD D'Agati, SM Factor, L Geng, S Tibara, ... Nature genetics 24 (1), 75-78, 2000 | 454 | 2000 |
Identification and characterization of polycystin-2, thePKD2 gene product Y Cai, Y Maeda, A Cedzich, VE Torres, G Wu, T Hayashi, T Mochizuki, ... Journal of Biological Chemistry 274 (40), 28557-28565, 1999 | 451 | 1999 |
Mutations in SEC63 cause autosomal dominant polycystic liver disease S Davila, L Furu, AG Gharavi, X Tian, T Onoe, Q Qian, A Li, Y Cai, ... Nature genetics 36 (6), 575-577, 2004 | 348 | 2004 |
Polycystin-2 traffics to cilia independently of polycystin-1 by using an N-terminal RVxP motif L Geng, D Okuhara, Z Yu, X Tian, Y Cai, S Shibazaki, S Somlo Journal of cell science 119 (7), 1383-1395, 2006 | 326 | 2006 |
A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formation SV Fedeles, X Tian, AR Gallagher, M Mitobe, S Nishio, SH Lee, Y Cai, ... Nature genetics 43 (7), 639-647, 2011 | 291 | 2011 |
Polyductin, the PKHD1 gene product, comprises isoforms expressed in plasma membrane, primary cilium, and cytoplasm LFC Menezes, Y Cai, Y Nagasawa, AMG Silva, ML Watkins, AM Da Silva, ... Kidney international 66 (4), 1345-1355, 2004 | 191 | 2004 |
Calcium dependence of polycystin-2 channel activity is modulated by phosphorylation at Ser812 Y Cai, G Anyatonwu, D Okuhara, KB Lee, Z Yu, T Onoe, CL Mei, Q Qian, ... Journal of Biological Chemistry 279 (19), 19987-19995, 2004 | 182 | 2004 |
Vascular expression of polycystin-2 VE Torres, Y Cai, XI Chen, GQ Wu, LIN Geng, KA Cleghorn, CM Johnson, ... Journal of the American Society of Nephrology 12 (1), 1-9, 2001 | 177 | 2001 |
Expression of PKD1 and PKD2 transcripts and proteins in human embryo and during normal kidney development V Chauvet, F Qian, N Boute, Y Cai, B Phakdeekitacharoen, LF Onuchic, ... The American journal of pathology 160 (3), 973-983, 2002 | 170 | 2002 |
Altered trafficking and stability of polycystins underlie polycystic kidney disease Y Cai, SV Fedeles, K Dong, G Anyatonwu, T Onoe, M Mitobe, JD Gao, ... The Journal of clinical investigation 124 (12), 5129-5144, 2014 | 159 | 2014 |
Polycystin-2 activation by inositol 1, 4, 5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1, 4, 5-trisphosphate receptor in a signaling … E Sammels, B Devogelaere, D Mekahli, G Bultynck, L Missiaen, JB Parys, ... Journal of Biological Chemistry 285 (24), 18794-18805, 2010 | 138 | 2010 |
Polycystin-2 expression is developmentally regulated GS Markowitz, Y Cai, L Li, G Wu, LC Ward, S Somlo, VD D’Agati American Journal of Physiology-Renal Physiology 277 (1), F17-F25, 1999 | 133 | 1999 |
Characterization of the exon structure of the polycystic kidney disease 2 gene (PKD2) T Hayashi, T Mochizuki, DM Reynolds, G Wu, Y Cai, S Somlo Genomics 44 (1), 131-136, 1997 | 131 | 1997 |
Analysis of the polycystins in aortic vascular smooth muscle cells Q Qian, M Li, Y Cai, CJ Ward, S Somlo, PC Harris, VE Torres Journal of the American Society of Nephrology 14 (9), 2280-2287, 2003 | 130 | 2003 |
Identification ofPKD2L, a HumanPKD2-Related Gene: Tissue-Specific Expression and Mapping to Chromosome 10q25 G Wu, T Hayashi, JH Park, M Dixit, DM Reynolds, L Li, Y Maeda, Y Cai, ... Genomics 54 (3), 564-568, 1998 | 128 | 1998 |
Aberrant splicing in the PKD2 gene as a cause of polycystic kidney disease DM Reynolds, T Hayashi, Y Cai, B Veldhuisen, TJ Watnick, XM Lens, ... Journal of the American Society of Nephrology 10 (11), 2342-2351, 1999 | 117 | 1999 |