| Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation F Wang, J Travins, B DeLaBarre, V Penard-Lacronique, S Schalm, ... Science 340 (6132), 622-626, 2013 | 968 | 2013 |
| Structural identification of two metabolites of catechins and their kinetics in human urine and blood after tea ingestion C Li, MJ Lee, S Sheng, X Meng, S Prabhu, B Winnik, B Huang, JY Chung, ... Chemical research in toxicology 13 (3), 177-184, 2000 | 367 | 2000 |
| Acquired resistance to the TRK inhibitor entrectinib in colorectal cancer M Russo, S Misale, G Wei, G Siravegna, G Crisafulli, L Lazzari, G Corti, ... Cancer discovery 6 (1), 36-44, 2016 | 310 | 2016 |
| Discovery of the First Potent Inhibitors of Mutant IDH1 That Lower Tumor 2-HG in Vivo J Popovici-Muller, JO Saunders, FG Salituro, JM Travins, S Yan, F Zhao, ... ACS Medicinal Chemistry Letters 3 (10), 850-855, 2012 | 254 | 2012 |
| Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosis-inducing agents J Zhu, X Song, HP Lin, DC Young, S Yan, VE Marquez, CS Chen Journal of the National Cancer Institute 94 (23), 1745-1757, 2002 | 216 | 2002 |
| Identification and structure–activity relationships of substituted pyridones as inhibitors of Pim-1 kinase IW Cheney, S Yan, T Appleby, H Walker, T Vo, N Yao, R Hamatake, ... Bioorganic & medicinal chemistry letters 17 (6), 1679-1683, 2007 | 209 | 2007 |
| Small molecule activation of PKM2 in cancer cells induces serine auxotrophy C Kung, J Hixon, S Choe, K Marks, S Gross, E Murphy, B DeLaBarre, ... Chemistry & biology 19 (9), 1187-1198, 2012 | 197 | 2012 |
| Structure–activity relationship (SAR) studies of quinoxalines as novel HCV NS5B RNA-dependent RNA polymerase inhibitors F Rong, S Chow, S Yan, G Larson, Z Hong, J Wu Bioorganic & Medicinal Chemistry Letters 17 (6), 1663-1666, 2007 | 137 | 2007 |
| Piperazine compounds as pyruvate kinase M2 modulators and their preparation, compositions and use in the treatment of cancer FG Salituro, JO Saunders, S Yan US Patent 8,889,667, 2014 | 83* | 2014 |
| Novel thiazolones as HCV NS5B polymerase allosteric inhibitors: Further designs, SAR, and X-ray complex structure S Yan, G Larson, JZ Wu, T Appleby, Y Ding, R Hamatake, Z Hong, N Yao Bioorganic & Medicinal Chemistry Letters 17 (1), 63-67, 2007 | 81 | 2007 |
| Isothiazoles as active-site inhibitors of HCV NS5B polymerase S Yan, T Appleby, E Gunic, JH Shim, T Tasu, H Kim, F Rong, H Chen, ... Bioorganic & Medicinal Chemistry Letters 17 (1), 28-33, 2007 | 80 | 2007 |
| Compounds, their pharmaceutical compositions and their uses as IDH1 mutants inhibitors for treating cancers S Cao, J Popovici-Muller, FG Salituro, J Saunders, X Tan, J Travins, ... | 77 | 2012 |
| Preparation of purinone compounds as kinase inhibitors S Yan, L Wang, LL Frye, W Chen, DJ Loury US Patent 8,501,724, 2013 | 75* | 2013 |
| Thiazolone-acylsulfonamides as novel HCV NS5B polymerase allosteric inhibitors: convergence of structure-based drug design and X-ray crystallographic study S Yan, T Appleby, G Larson, JZ Wu, RK Hamatake, Z Hong, N Yao Bioorganic & medicinal chemistry letters 17 (7), 1991-1995, 2007 | 75 | 2007 |
| Therapeutically active compounds and their methods of use G Cianchetta, B Delabarre, J Popovici-Muller, FG Salituro, JO Saunders, ... US Patent 9,732,062, 2017 | 73 | 2017 |
| Structure-based design of a novel thiazolone scaffold as HCV NS5B polymerase allosteric inhibitors S Yan, T Appleby, G Larson, JZ Wu, R Hamatake, Z Hong, N Yao Bioorganic & medicinal chemistry letters 16 (22), 5888-5891, 2006 | 71 | 2006 |
| Modulation of Carbenic Reactivity by π-Complexation to Aromatics RA Moss, S Yan, K Krogh-Jespersen Journal of the American Chemical Society 120 (5), 1088-1089, 1998 | 54 | 1998 |
| Ab Initio Electronic Structure Calculations on Chlorocarbene− Ethylene and Chlorocarbene− Benzene Complexes K Krogh-Jespersen, S Yan, RA Moss Journal of the American Chemical Society 121 (26), 6269-6274, 1999 | 51 | 1999 |
| Preparation of purinone compounds as kinase inhibitors S Yan, L Wang, LL Frye, W Chen, DJ Loury US Patent 9,469,642, 2016 | 49* | 2016 |
| Therapeutically active compositions and their methods of use J Popovici-Muller, FG Salituro, J Saunders, J Travins, S Yan US Patent App. 13/810,410, 2013 | 48 | 2013 |