| Supporting aspartate biosynthesis is an essential function of respiration in proliferating cells LB Sullivan, DY Gui, AM Hosios, LN Bush, E Freinkman, ... Cell 162 (3), 552-563, 2015 | 1137 | 2015 |
| Amino acids rather than glucose account for the majority of cell mass in proliferating mammalian cells AM Hosios, VC Hecht, LV Danai, MO Johnson, JC Rathmell, ... Developmental cell 36 (5), 540-549, 2016 | 661 | 2016 |
| PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells WJ Israelsen, TL Dayton, SM Davidson, BP Fiske, AM Hosios, G Bellinger, ... Cell 155 (2), 397-409, 2013 | 567 | 2013 |
| Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers JR Mayers, ME Torrence, LV Danai, T Papagiannakopoulos, ... Science 353 (6304), 1161-1165, 2016 | 562 | 2016 |
| Environment dictates dependence on mitochondrial complex I for NAD+ and aspartate production and determines cancer cell sensitivity to metformin DY Gui, LB Sullivan, A Luengo, AM Hosios, LN Bush, N Gitego, ... Cell metabolism 24 (5), 716-727, 2016 | 334 | 2016 |
| Aspartate is an endogenous metabolic limitation for tumour growth LB Sullivan, A Luengo, LV Danai, LN Bush, FF Diehl, AM Hosios, AN Lau, ... Nature cell biology 20 (7), 782-788, 2018 | 308 | 2018 |
| Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation SY Lunt, V Muralidhar, AM Hosios, WJ Israelsen, DY Gui, L Newhouse, ... Molecular cell 57 (1), 95-107, 2015 | 261 | 2015 |
| The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals ME Torrence, MR MacArthur, AM Hosios, AJ Valvezan, JM Asara, ... Elife 10, e63326, 2021 | 172 | 2021 |
| The redox requirements of proliferating mammalian cells AM Hosios, MG Vander Heiden Journal of Biological Chemistry 293 (20), 7490-7498, 2018 | 138 | 2018 |
| Pyrimidine homeostasis is accomplished by directed overflow metabolism ML Reaves, BD Young, AM Hosios, YF Xu, JD Rabinowitz Nature 500 (7461), 237-241, 2013 | 120 | 2013 |
| Lack of evidence for PKM2 protein kinase activity AM Hosios, BP Fiske, DY Gui, MG Vander Heiden Molecular cell 59 (5), 850-857, 2015 | 107 | 2015 |
| Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth AG Cox, A Tsomides, D Yimlamai, KL Hwang, J Miesfeld, GG Galli, ... The EMBO journal 37 (22), e100294, 2018 | 89 | 2018 |
| Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer A Luengo, KL Abbott, SM Davidson, AM Hosios, B Faubert, SH Chan, ... Nature communications 10 (1), 5604, 2019 | 56 | 2019 |
| Cancer signaling drives cancer metabolism: AKT and the Warburg effect AM Hosios, BD Manning Cancer Research 81 (19), 4896-4898, 2021 | 47 | 2021 |
| Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited Z Li, BW Ji, PD Dixit, K Tchourine, EC Lien, AM Hosios, KL Abbott, ... Nature metabolism 4 (6), 711-723, 2022 | 44 | 2022 |
| Acetate metabolism in cancer cells AM Hosios, MG Vander Heiden Cancer & metabolism 2, 1-2, 2014 | 43 | 2014 |
| A New System for Comparative Functional Genomics of Saccharomyces Yeasts AA Caudy, Y Guan, Y Jia, C Hansen, C DeSevo, AP Hayes, J Agee, ... Genetics 195 (1), 275-287, 2013 | 37 | 2013 |
| Biophysical changes reduce energetic demand in growth factor–deprived lymphocytes VC Hecht, LB Sullivan, RJ Kimmerling, DH Kim, AM Hosios, ... Journal of Cell Biology 212 (4), 439-447, 2016 | 27 | 2016 |
| mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species AM Hosios, ME Wilkinson, MC McNamara, KC Kalafut, ME Torrence, ... Nature metabolism 4 (12), 1792-1811, 2022 | 26 | 2022 |
| Cooperative nutrient accumulation sustains growth of mammalian cells S Son, MM Stevens, HX Chao, C Thoreen, AM Hosios, LD Schweitzer, ... Scientific reports 5 (1), 17401, 2015 | 24 | 2015 |