| Recent advances in the synthesis of biologically active spirooxindoles MMM Santos Tetrahedron 70 (52), 9735-9757, 2014 | 409 | 2014 |
| Michael acceptors as cysteine protease inhibitors MMM Santos, R Moreira Mini reviews in medicinal chemistry 7 (10), 1040-1050, 2007 | 194 | 2007 |
| Reaction of naphthoquinones with substituted nitromethanes. Facile synthesis and antifungal activity of naphtho [2, 3-d] isoxazole-4, 9-diones MMM Santos, N Faria, J Iley, SJ Coles, MB Hursthouse, ML Martins, ... Bioorganic & medicinal chemistry letters 20 (1), 193-195, 2010 | 140 | 2010 |
| Synthesis of novel spiropyrazoline oxindoles and evaluation of cytotoxicity in cancer cell lines  Monteiro, LM Gonçalves, MMM Santos European Journal of Medicinal Chemistry 79, 266-272, 2014 | 105 | 2014 |
| Enhancing macrocyclic diterpenes as multidrug-resistance reversers: structure–activity studies on jolkinol D derivatives M Reis, RJ Ferreira, MMM Santos, DJVA dos Santos, J Molnár, ... Journal of Medicinal Chemistry 56 (3), 748-760, 2013 | 75 | 2013 |
| Straightforward Methodology for the Enantioselective Synthesis of Benzo[a]- and Indolo[2,3-a]quinolizidines M Amat, MMM Santos, O Bassas, N Llor, C Escolano, A Gómez-Esqué, ... The Journal of Organic Chemistry 72 (14), 5193-5201, 2007 | 75 | 2007 |
| Synthesis and evaluation of spiroisoxazoline oxindoles as anticancer agents CJA Ribeiro, JD Amaral, CMP Rodrigues, R Moreira, MMM Santos Bioorganic & medicinal chemistry 22 (1), 577-584, 2014 | 70 | 2014 |
| Antidepressant-like and antinociceptive-like actions of 4-(4′-chlorophenyl)-6-(4 ″-methylphenyl)-2-hydrazinepyrimidine Mannich base in mice ALS Rodrigues, JM Rosa, VM Gadotti, EC Goulart, MM Santos, AV Silva, ... Pharmacology Biochemistry and Behavior 82 (1), 156-162, 2005 | 67 | 2005 |
| Enantioselective formal synthesis of (+)-dihydrocorynantheine and (−)-dihydrocorynantheol M Amat, A Gómez-Esqué, C Escolano, MMM Santos, E Molins, J Bosch The Journal of Organic Chemistry 74 (3), 1205-1211, 2009 | 56 | 2009 |
| Oxazoloisoindolinones with in vitro antitumor activity selectively activate a p53-pathway through potential inhibition of the p53–MDM2 interaction J Soares, NAL Pereira, Â Monteiro, M Leao, C Bessa, DJVA Dos Santos, ... European Journal of Pharmaceutical Sciences 66, 138-147, 2015 | 53 | 2015 |
| An update on MDMX and dual MDM2/X inhibitors M Espadinha, V Barcherini, EA Lopes, MMM Santos Current topics in medicinal chemistry 18 (8), 647-660, 2018 | 51 | 2018 |
| Enantioselective formal synthesis of ent-rhynchophylline and ent-isorhynchophylline M Amat, C Ramos, M Pérez, E Molins, P Florindo, MMM Santos, J Bosch Chemical Communications 49 (19), 1954-1956, 2013 | 51 | 2013 |
| Enantioselective spirocyclizations from tryptophanol-derived oxazolopiperidone lactams M Amat, MMM Santos, AM Gómez, D Jokic, E Molins, J Bosch Organic Letters 9 (15), 2907-2910, 2007 | 51 | 2007 |
| DIMP 53‐1: a novel small‐molecule dual inhibitor of p53–MDM 2/X interactions with multifunctional p53‐dependent anticancer properties J Soares, M Espadinha, L Raimundo, H Ramos, AS Gomes, S Gomes, ... Molecular Oncology 11 (6), 612-627, 2017 | 49 | 2017 |
| Reactivation of wild-type and mutant p53 by tryptophanolderived oxazoloisoindolinone SLMP53-1, a novel anticancer small-molecule J Soares, L Raimundo, NAL Pereira, Â Monteiro, S Gomes, C Bessa, ... Oncotarget 7 (4), 4326, 2015 | 49 | 2015 |
| A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins J Soares, L Raimundo, NAL Pereira, DJVA dos Santos, M Pérez, ... Pharmacological Research 95, 42-52, 2015 | 49 | 2015 |
| Chemical variations on the p53 reactivation theme CJA Ribeiro, CMP Rodrigues, R Moreira, MMM Santos Pharmaceuticals 9 (2), 25, 2016 | 47 | 2016 |
| Squaric acid: a valuable scaffold for developing antimalarials? SP Kumar, PMC Glória, LM Gonçalves, J Gut, PJ Rosenthal, R Moreira, ... MedChemComm 3 (4), 489-493, 2012 | 45 | 2012 |
| Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials SP Kumar, J Gut, RC Guedes, PJ Rosenthal, MMM Santos, R Moreira European journal of medicinal chemistry 46 (3), 927-933, 2011 | 45 | 2011 |
| Enantiopure indolizinoindolones with in vitro activity against blood‐and liver‐stage malaria parasites NAL Pereira, Â Monteiro, M Machado, J Gut, E Molins, MJ Perry, ... ChemMedChem 10 (12), 2080-2089, 2015 | 42 | 2015 |
Milton de Arruda MartinsProfessor of Medicine, School of Medicine, University of Sao Paulo, BrazilVerified email at usp.br