| mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt KE O'Reilly, F Rojo, QB She, D Solit, GB Mills, D Smith, H Lane, ... Cancer research 66 (3), 1500-1508, 2006 | 3033 | 2006 |
| RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF PI Poulikakos, C Zhang, G Bollag, KM Shokat, N Rosen Nature 464 (7287), 427-430, 2010 | 2070 | 2010 |
| Crystal structure of an Hsp90–geldanamycin complex: targeting of a protein chaperone by an antitumor agent CE Stebbins, AA Russo, C Schneider, N Rosen, FU Hartl, NP Pavletich Cell 89 (2), 239-250, 1997 | 1763 | 1997 |
| RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF (V600E) PI Poulikakos, Y Persaud, M Janakiraman, X Kong, C Ng, G Moriceau, ... Nature 480 (7377), 387-390, 2011 | 1705 | 2011 |
| BRAF mutation predicts sensitivity to MEK inhibition DB Solit, LA Garraway, CA Pratilas, A Sawai, G Getz, A Basso, Q Ye, ... Nature 439 (7074), 358-362, 2006 | 1562 | 2006 |
| Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer BS Carver, C Chapinski, J Wongvipat, H Hieronymus, Y Chen, ... Cancer cell 19 (5), 575-586, 2011 | 1362 | 2011 |
| AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity S Chandarlapaty, A Sawai, M Scaltriti, V Rodrik-Outmezguine, ... Cancer cell 19 (1), 58-71, 2011 | 1098 | 2011 |
| Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function AD Basso, DB Solit, G Chiosis, B Giri, P Tsichlis, N Rosen Journal of Biological Chemistry 277 (42), 39858-39866, 2002 | 794 | 2002 |
| Clinical sequencing defines the genomic landscape of metastatic colorectal cancer R Yaeger, WK Chatila, MD Lipsyc, JF Hechtman, A Cercek, ... Cancer cell 33 (1), 125-136. e3, 2018 | 779 | 2018 |
| Targeted drug delivery strategies for precision medicines MT Manzari, Y Shamay, H Kiguchi, N Rosen, M Scaltriti, DA Heller Nature Reviews Materials 6 (4), 351-370, 2021 | 738 | 2021 |
| V600EBRAF is associated with disabled feedback inhibition of RAF–MEK signaling and elevated transcriptional output of the pathway CA Pratilas, BS Taylor, Q Ye, A Viale, C Sander, DB Solit, N Rosen Proceedings of the National Academy of Sciences 106 (11), 4519-4524, 2009 | 696 | 2009 |
| Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism P Lito, M Solomon, LS Li, R Hansen, N Rosen Science 351 (6273), 604-608, 2016 | 694 | 2016 |
| Tumor adaptation and resistance to RAF inhibitors P Lito, N Rosen, DB Solit Nature medicine 19 (11), 1401-1409, 2013 | 688 | 2013 |
| Cyclin D expression is controlled post-transcriptionally via a phosphatidylinositol 3-kinase/Akt-dependent pathway RC Muise-Helmericks, HL Grimes, A Bellacosa, SE Malstrom, PN Tsichlis, ... Journal of Biological Chemistry 273 (45), 29864-29872, 1998 | 682 | 1998 |
| The tyrosine kinase inhibitor ZD1839 (“Iressa”) inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells MM Moasser, A Basso, SD Averbuch, N Rosen Cancer research 61 (19), 7184-7188, 2001 | 666 | 2001 |
| Drugging the cancer chaperone HSP90: combinatorial therapeutic exploitation of oncogene addiction and tumor stress P Workman, F Burrows, LEN Neckers, N Rosen Annals of the New York Academy of Sciences 1113 (1), 202-216, 2007 | 657 | 2007 |
| Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity LH Saal, P Johansson, K Holm, SK Gruvberger-Saal, QB She, M Maurer, ... Proceedings of the National Academy of Sciences 104 (18), 7564-7569, 2007 | 647 | 2007 |
| PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer V Serra, M Scaltriti, L Prudkin, PJA Eichhorn, YH Ibrahim, ... Oncogene 30 (22), 2547-2557, 2011 | 634 | 2011 |
| The advantages of targeted protein degradation over inhibition: an RTK case study GM Burslem, BE Smith, AC Lai, S Jaime-Figueroa, DC McQuaid, ... Cell chemical biology 25 (1), 67-77. e3, 2018 | 631 | 2018 |
| Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas P Lito, CA Pratilas, EW Joseph, M Tadi, E Halilovic, M Zubrowski, ... Cancer cell 22 (5), 668-682, 2012 | 622 | 2012 |
David SolitCo-Director, Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer CenterVerified email at mskcc.org
