| GPCR-G protein-β-arrestin super-complex mediates sustained G protein signaling ARB Thomsen, B Plouffe, TJ Cahill, AK Shukla, JT Tarrasch, AM Dosey, ... Cell 166 (4), 907-919, 2016 | 573 | 2016 |
| Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region AJ Venkatakrishnan, X Deupi, G Lebon, FM Heydenreich, T Flock, ... Nature 536 (7617), 484-487, 2016 | 338 | 2016 |
| Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor S Isogai, X Deupi, C Opitz, FM Heydenreich, CJ Tsai, F Brueckner, ... Nature 530 (7589), 237-241, 2016 | 202 | 2016 |
| GPCR activation mechanisms across classes and macro/microscales AS Hauser, AJ Kooistra, C Munk, FM Heydenreich, DB Veprintsev, ... Nature structural & molecular biology 28 (11), 879-888, 2021 | 180 | 2021 |
| A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling A Beautrait, JS Paradis, B Zimmerman, J Giubilaro, L Nikolajev, ... Nature communications 8 (1), 15054, 2017 | 161 | 2017 |
| How GPCR phosphorylation patterns orchestrate arrestin-mediated signaling NR Latorraca, M Masureel, SA Hollingsworth, FM Heydenreich, ... Cell 183 (7), 1813-1825. e18, 2020 | 130 | 2020 |
| Stabilization of G protein-coupled receptors by point mutations FM Heydenreich, Z Vuckovic, M Matkovic, DB Veprintsev Frontiers in pharmacology 6, 82, 2015 | 100 | 2015 |
| Nitrogen and Carbon Status Are Integrated at the Transcriptional Level by the Nitrogen Regulator NtrC In Vivo J Schumacher, V Behrends, Z Pan, DR Brown, F Heydenreich, MR Lewis, ... MBio 4 (6), 10.1128/mbio. 00881-13, 2013 | 65 | 2013 |
| The pocketome of G-protein-coupled receptors reveals previously untargeted allosteric sites JB Hedderich, M Persechino, K Becker, FM Heydenreich, T Gutermuth, ... Nature Communications 13 (1), 2567, 2022 | 62 | 2022 |
| Membrane phosphoinositides regulate GPCR-β-arrestin complex assembly and dynamics J Janetzko, R Kise, B Barsi-Rhyne, DH Siepe, FM Heydenreich, ... Cell 185 (24), 4560-4573. e19, 2022 | 56 | 2022 |
| High-throughput mutagenesis using a two-fragment PCR approach FM Heydenreich, T Miljuš, R Jaussi, R Benoit, D Milić, DB Veprintsev Scientific reports 7 (1), 6787, 2017 | 56 | 2017 |
| AAscan, PCRdesign and MutantChecker: a suite of programs for primer design and sequence analysis for high-throughput scanning mutagenesis D Sun, MK Ostermaier, FM Heydenreich, D Mayer, R Jaussi, J Standfuss, ... PLoS One 8 (10), e78878, 2013 | 47 | 2013 |
| Activity of the mycobacterial proteasomal ATPase Mpa is reversibly regulated by pupylation CL Delley, F Striebel, FM Heydenreich, D Özcelik, E Weber-Ban Journal of Biological Chemistry 287 (11), 7907-7914, 2012 | 47 | 2012 |
| GlnK facilitates the dynamic regulation of bacterial nitrogen assimilation A Gosztolai, J Schumacher, V Behrends, JG Bundy, F Heydenreich, ... Biophysical journal 112 (10), 2219-2230, 2017 | 24 | 2017 |
| Functional solubilization of the β2-adrenoceptor using diisobutylene maleic acid CR Harwood, DA Sykes, BL Hoare, FM Heydenreich, R Uddin, ... Iscience 24 (12), 2021 | 15* | 2021 |
| Computationally designed GPCR quaternary structures bias signaling pathway activation JS Paradis, X Feng, B Murat, RE Jefferson, B Sokrat, M Szpakowska, ... Nature communications 13 (1), 6826, 2022 | 12 | 2022 |
| Membrane phosphoinositides stabilize GPCR-arrestin complexes and offer temporal control of complex assembly and dynamics J Janetzko, R Kise, B Barsi-Ryne, DH Siepe, FM Heydenreich, ... Biorxiv, 2021.10. 09.463790, 2021 | 8 | 2021 |
| Molecular determinants of ligand efficacy and potency in GPCR signaling FM Heydenreich, M Marti-Solano, M Sandhu, BK Kobilka, M Bouvier, ... Science 382 (6677), eadh1859, 2023 | 7 | 2023 |
| Michaelis-menten quantification of ligand signaling bias applied to the promiscuous vasopressin V2 receptor FM Heydenreich, B Plouffe, A Rizk, D Milić, J Zhou, B Breton, C Le Gouill, ... Molecular Pharmacology 102 (3), 139-149, 2022 | 6 | 2022 |
| Diverse chemotypes drive biased signaling by cannabinoid receptors T Miljuš, FM Heydenreich, T Gazzi, A Kimbara, M Rogers-Evans, ... bioRxiv, 2020.11. 09.375162, 2020 | 6 | 2020 |
Michel BouvierProfessor of Biochem. and Mol. Med., IRIC, Univ. de MontréalVerified email at umontreal.ca