| Upstream and downstream of mTOR N Hay, N Sonenberg Genes & development 18 (16), 1926-1945, 2004 | 5532 | 2004 |
| The pentose phosphate pathway and cancer KC Patra, N Hay Trends in biochemical sciences 39 (8), 347-354, 2014 | 1437 | 2014 |
| The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. SG Kennedy, AJ Wagner, SD Conzen, J Jordan, A Bellacosa, PN Tsichlis, ... Genes & development 11 (6), 701-713, 1997 | 1364 | 1997 |
| Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene WS Chen, PZ Xu, K Gottlob, ML Chen, K Sokol, T Shiyanova, I Roninson, ... Genes & development 15 (17), 2203-2208, 2001 | 1240 | 2001 |
| AMPK regulates NADPH homeostasis to promote tumour cell survival during energy stress SM Jeon, NS Chandel, N Hay Nature 485 (7400), 661-665, 2012 | 1213 | 2012 |
| The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB ES Kandel, N Hay Experimental cell research 253 (1), 210-229, 1999 | 1207 | 1999 |
| Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase K Gottlob, N Majewski, S Kennedy, E Kandel, RB Robey, N Hay Genes & development 15 (11), 1406-1418, 2001 | 1158 | 2001 |
| 4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt (PKB) signaling pathway AC Gingras, SG Kennedy, MA O’Leary, N Sonenberg, N Hay Genes & development 12 (4), 502-513, 1998 | 1145 | 1998 |
| Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy? N Hay Nature Reviews Cancer 16 (10), 635-649, 2016 | 1094 | 2016 |
| The two TORCs and AKT PT Bhaskar, N Hay Developmental cell 12 (4), 487-502, 2007 | 1046 | 2007 |
| Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2 X Peng, PZ Xu, ML Chen, A Hahn-Windgassen, J Skeen, J Jacobs, ... Genes & development 17 (11), 1352-1365, 2003 | 1002 | 2003 |
| The Akt-mTOR tango and its relevance to cancer N Hay Cancer cell 8 (3), 179-183, 2005 | 957 | 2005 |
| Akt determines replicative senescence and oxidative or oncogenic premature senescence and sensitizes cells to oxidative apoptosis V Nogueira, Y Park, CC Chen, PZ Xu, ML Chen, I Tonic, T Unterman, ... Cancer cell 14 (6), 458-470, 2008 | 891 | 2008 |
| Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer KC Patra, Q Wang, PT Bhaskar, L Miller, Z Wang, W Wheaton, N Chandel, ... Cancer cell 24 (2), 213-228, 2013 | 864 | 2013 |
| Akt/Protein Kinase B Inhibits Cell Death by Preventing the Release of Cytochrome c from Mitochondria SG Kennedy, ES Kandel, TK Cross, N Hay Molecular and cellular biology 19 (8), 5800-5810, 1999 | 859 | 1999 |
| Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak N Majewski, V Nogueira, P Bhaskar, PE Coy, JE Skeen, K Gottlob, ... Molecular cell 16 (5), 819-830, 2004 | 774 | 2004 |
| Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1. AJ Wagner, JM Kokontis, N Hay Genes & development 8 (23), 2817-2830, 1994 | 763 | 1994 |
| Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity A Hahn-Windgassen, V Nogueira, CC Chen, JE Skeen, N Sonenberg, ... Journal of Biological Chemistry 280 (37), 32081-32089, 2005 | 710 | 2005 |
| Is Akt the “Warburg kinase”?—Akt-energy metabolism interactions and oncogenesis RB Robey, N Hay Seminars in cancer biology 19 (1), 25-31, 2009 | 688 | 2009 |
| Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt RB Robey, N Hay Oncogene 25 (34), 4683-4696, 2006 | 664 | 2006 |
