Specific killing of BRCA2-deficient tumours with inhibitors of poly (ADP-ribose) polymerase HE Bryant, N Schultz, HD Thomas, KM Parker, D Flower, E Lopez, S Kyle, ... Nature 434 (7035), 913-917, 2005 | 5785 | 2005 |
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints J Bartkova, N Rezaei, M Liontos, P Karakaidos, D Kletsas, N Issaeva, ... Nature 444 (7119), 633-637, 2006 | 2332 | 2006 |
DNA repair pathways as targets for cancer therapy T Helleday, E Petermann, C Lundin, B Hodgson, RA Sharma Nature Reviews Cancer 8 (3), 193-204, 2008 | 2060 | 2008 |
Mechanisms underlying mutational signatures in human cancers T Helleday, S Eshtad, S Nik-Zainal Nature reviews genetics 15 (9), 585-598, 2014 | 977 | 2014 |
The underlying mechanism for the PARP and BRCA synthetic lethality: clearing up the misunderstandings T Helleday Molecular oncology 5 (4), 387-393, 2011 | 967 | 2011 |
Replication stress links structural and numerical cancer chromosomal instability RA Burrell, SE McClelland, D Endesfelder, P Groth, MC Weller, N Shaikh, ... Nature 494 (7438), 492-496, 2013 | 957 | 2013 |
Hydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair E Petermann, ML Orta, N Issaeva, N Schultz, T Helleday Molecular cell 37 (4), 492-502, 2010 | 923 | 2010 |
DNA double-strand break repair: from mechanistic understanding to cancer treatment T Helleday, J Lo, DC van Gent, BP Engelward DNA repair 6 (7), 923-935, 2007 | 884 | 2007 |
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair CS Sørensen, LT Hansen, J Dziegielewski, RG Syljuåsen, C Lundin, ... Nature cell biology 7 (2), 195-201, 2005 | 765 | 2005 |
PARP is activated at stalled forks to mediate Mre11‐dependent replication restart and recombination HE Bryant, E Petermann, N Schultz, AS Jemth, O Loseva, N Issaeva, ... The EMBO journal 28 (17), 2601-2615, 2009 | 734 | 2009 |
Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage RG Syljuåsen, CS Sørensen, LT Hansen, K Fugger, C Lundin, ... Molecular and cellular biology, 2005 | 645 | 2005 |
MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool H Gad, T Koolmeister, AS Jemth, S Eshtad, SA Jacques, CE Ström, ... Nature 508 (7495), 215-221, 2014 | 564 | 2014 |
DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells C Arnaudeau, C Lundin, T Helleday Journal of molecular biology 307 (5), 1235-1245, 2001 | 522 | 2001 |
miR-182-mediated downregulation of BRCA1 impacts DNA repair and sensitivity to PARP inhibitors P Moskwa, FM Buffa, Y Pan, R Panchakshari, P Gottipati, RJ Muschel, ... Molecular cell 41 (2), 210-220, 2011 | 517 | 2011 |
Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks C Lundin, M North, K Erixon, K Walters, D Jenssen, ASH Goldman, ... Nucleic acids research 33 (12), 3799-3811, 2005 | 502 | 2005 |
Break-induced replication repair of damaged forks induces genomic duplications in human cells L Costantino, SK Sotiriou, JK Rantala, S Magin, E Mladenov, T Helleday, ... Science 343 (6166), 88-91, 2014 | 492 | 2014 |
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity E Berglund, J Maaskola, N Schultz, S Friedrich, M Marklund, ... Nature communications 9 (1), 2419, 2018 | 483 | 2018 |
Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1 SF El-Khamisy, GM Saifi, M Weinfeld, F Johansson, T Helleday, JR Lupski, ... Nature 434 (7029), 108-113, 2005 | 481 | 2005 |
SETD2-dependent histone H3K36 trimethylation is required for homologous recombination repair and genome stability SX Pfister, S Ahrabi, LP Zalmas, S Sarkar, F Aymard, CZ Bachrati, ... Cell reports 7 (6), 2006-2018, 2014 | 469 | 2014 |
Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells N Saleh-Gohari, T Helleday Nucleic acids research 32 (12), 3683-3688, 2004 | 453 | 2004 |