| FRET biosensor uncovers cAMP nano-domains at β-adrenergic targets that dictate precise tuning of cardiac contractility NC Surdo, M Berrera, A Koschinski, M Brescia, MR Machado, C Carr, ... Nature communications 8 (1), 15031, 2017 | 203 | 2017 |
| A computational model of induced pluripotent stem‐cell derived cardiomyocytes incorporating experimental variability from multiple data sources DC Kernik, S Morotti, HD Wu, P Garg, HJ Duff, J Kurokawa, J Jalife, ... The Journal of physiology 597 (17), 4533-4564, 2019 | 126 | 2019 |
| Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes MA Nystoriak, M Nieves-Cintrón, T Patriarchi, OR Buonarati, MP Prada, ... Science signaling 10 (463), eaaf9647, 2017 | 121 | 2017 |
| A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+ loading and CaMKII S Morotti, AG Edwards, AD McCulloch, DM Bers, E Grandi The Journal of physiology 592 (6), 1181-1197, 2014 | 114 | 2014 |
| Trafficking Defects and Gating Abnormalities of a Novel SCN5A Mutation Question Gene-Specific Therapy in Long QT Syndrome Type 3 Y Ruan, M Denegri, N Liu, T Bachetti, M Seregni, S Morotti, S Severi, ... Circulation research 106 (8), 1374-1383, 2010 | 113 | 2010 |
| General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy Z Li, GR Mirams, T Yoshinaga, BJ Ridder, X Han, JE Chen, ... Clinical Pharmacology & Therapeutics 107 (1), 102-111, 2020 | 80 | 2020 |
| A heart for diversity: simulating variability in cardiac arrhythmia research H Ni, S Morotti, E Grandi Frontiers in physiology 9, 958, 2018 | 78 | 2018 |
| Ca2+ current facilitation is CaMKII-dependent and has arrhythmogenic consequences DM Bers, S Morotti Frontiers in pharmacology 5, 144, 2014 | 74 | 2014 |
| β-adrenergic effects on cardiac myofilaments and contraction in an integrated rabbit ventricular myocyte model JA Negroni, S Morotti, EC Lascano, AV Gomes, E Grandi, JL Puglisi, ... Journal of molecular and cellular cardiology 81, 162-175, 2015 | 65 | 2015 |
| Hypokalemia promotes arrhythmia by distinct mechanisms in atrial and ventricular myocytes K Tazmini, M Frisk, M Laasmaa, A Lewalle, S Morotti, DB Lipsett, ... Biophysical Journal 118 (3), 103a, 2020 | 60 | 2020 |
| Theoretical study of L‐type Ca2+ current inactivation kinetics during action potential repolarization and early afterdepolarizations S Morotti, E Grandi, A Summa, KS Ginsburg, DM Bers The Journal of physiology 590 (18), 4465-4481, 2012 | 58 | 2012 |
| Logistic regression analysis of populations of electrophysiological models to assess proarrythmic risk S Morotti, E Grandi MethodsX 4, 25-34, 2017 | 55 | 2017 |
| Atrial-selective targeting of arrhythmogenic phase-3 early afterdepolarizations in human myocytes S Morotti, AD McCulloch, DM Bers, AG Edwards, E Grandi Journal of Molecular and Cellular Cardiology 96, 63-71, 2016 | 53 | 2016 |
| Adenylyl cyclase 5–generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia AU Syed, GR Reddy, D Ghosh, MP Prada, MA Nystoriak, S Morotti, ... The Journal of clinical investigation 129 (8), 3140-3152, 2019 | 49 | 2019 |
| Quantitative analysis of the Ca2+‐dependent regulation of delayed rectifier K+ current IKs in rabbit ventricular myocytes DC Bartos, S Morotti, KS Ginsburg, E Grandi, DM Bers The Journal of physiology 595 (7), 2253-2268, 2017 | 48 | 2017 |
| Interplay of voltage and Ca-dependent inactivation of L-type Ca current E Grandi, S Morotti, KS Ginsburg, S Severi, DM Bers Progress in biophysics and molecular biology 103 (1), 44-50, 2010 | 45 | 2010 |
| CaMKIIδC Drives Early Adaptive Ca2+ Change and Late Eccentric Cardiac Hypertrophy S Ljubojevic-Holzer, AW Herren, N Djalinac, J Voglhuber, S Morotti, ... Circulation research 127 (9), 1159-1178, 2020 | 43 | 2020 |
| Enhanced depolarization drive in failing rabbit ventricular myocytes: calcium-dependent and β-adrenergic effects on late sodium, L-type calcium, and sodium-calcium exchange … B Hegyi, S Morotti, C Liu, KS Ginsburg, J Bossuyt, L Belardinelli, LT Izu, ... Circulation: Arrhythmia and Electrophysiology 12 (3), e007061, 2019 | 36 | 2019 |
| Sex‐specific classification of drug‐induced torsade de pointes susceptibility using cardiac simulations and machine learning A Fogli Iseppe, H Ni, S Zhu, X Zhang, R Coppini, PC Yang, U Srivatsa, ... Clinical Pharmacology & Therapeutics 110 (2), 380-391, 2021 | 34 | 2021 |
| Inward rectifier potassium channels (Kir2. x) and caveolin-3 domain–specific interaction: implications for purkinje cell–dependent ventricular arrhythmias R Vaidyanathan, H Van Ert, KT Haq, S Morotti, S Esch, EC McCune, ... Circulation: Arrhythmia and Electrophysiology 11 (1), e005800, 2018 | 33 | 2018 |
Eleonora GrandiUniversity of California Davis OR University of Bologna OR Loyola University ChicagoVerified email at ucdavis.edu